Immunology of the ageing kidney

Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology

(2019) Saba Nayar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

The widening spectrum of immunological memory

(2018) Colleen M Lau et al.   CURRENT OPINION IN IMMUNOLOGY

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury

(2018) Arthur Lau et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Interleukin-1β by Canakinumab and Cardiovascular Outcomes in Patients With Chronic Kidney Disease

(2018) Paul M Ridker et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inflammation and Trajectory of Renal Function in Community-Dwelling Older Adults

(2018) Shabnam Salimi et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Interleukin-1βActivates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis

(2018) Dario R. Lemos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Global glomerulosclerosis with nephrotic syndrome; the clinical importance of age adjustment

(2018) Musab S. Hommos et al.   KIDNEY INTERNATIONAL

The human heart contains distinct macrophage subsets with divergent origins and functions

(2018) Geetika Bajpai et al.   NATURE MEDICINE

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

CXCR3high CD8+ T cells with naïve phenotype and high capacity for IFN-γ production are generated during homeostatic T-cell proliferation

(2018) Aiko Kato et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Successful and Maladaptive T Cell Aging

(2017) Jörg J. Goronzy et al.   IMMUNITY

The immunology of hypertension

(2017) Allison E. Norlander et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists

(2017) Talibah U. Metcalf et al.   JOURNAL OF IMMUNOLOGY

AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms

(2017) Liyu He et al.   KIDNEY INTERNATIONAL

Molecular mechanisms of renal aging

(2017) Roland Schmitt et al.   KIDNEY INTERNATIONAL

Salt-responsive gut commensal modulates TH17 axis and disease

(2017) Nicola Wilck et al.   NATURE

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

(2017) David Furman et al.   NATURE MEDICINE

Barrier-tissue macrophages: functional adaptation to environmental challenges

(2017) Allan McI Mowat et al.   NATURE MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammaging and ‘Garb-aging’

(2017) Claudio Franceschi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Fountain of Youth by Targeting Senescent Cells?

(2017) Peter L.J. de Keizer   TRENDS IN MOLECULAR MEDICINE

The Origins and Functions of Tissue-Resident Macrophages in Kidney Development

(2017) David A. D. Munro et al.   Frontiers in Physiology

Postnatal Innate Immune Development: From Birth to Adulthood

(2017) Anastasia Georgountzou et al.   Frontiers in Immunology

Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity

(2017) Claudio Franceschi et al.   Frontiers in Immunology

Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma

(2017) Heather L. Thompson et al.   Frontiers in Immunology

Role of the Gut Microbiome in Uremia: A Potential Therapeutic Target

(2016) Ali Ramezani et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Chemokines and Chemokine Receptors in Lymphoid Tissue Dynamics

(2016) Olga Schulz et al.   Annual Review of Immunology

Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule

(2016) Takeshi Yamamoto et al.   Autophagy

Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages

(2016) Efstathios G. Stamatiades et al.   CELL

Immune senescence: significance of the stromal microenvironment

(2016) A. R. Masters et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Gut Microbiota and Extreme Longevity

(2016) Elena Biagi et al.   CURRENT BIOLOGY

Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney

(2016) Christian F. Krebs et al.   IMMUNITY

Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals

(2016) Catherine M. Sawai et al.   IMMUNITY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution

(2016) Yoko Hamazaki et al.   IMMUNOLOGICAL REVIEWS

Disorganization of the splenic microanatomy in ageing mice

(2016) Danielle Aw et al.   IMMUNOLOGY

Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury

(2016) Irina A. Leaf et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity accelerates T cell senescence in murine visceral adipose tissue

(2016) Kohsuke Shirakawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging

(2016) Kira Young et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice

(2016) Keiko Sakamoto et al.   JOURNAL OF IMMUNOLOGY

Renal Aging: Causes and Consequences

(2016) Eoin D. O’Sullivan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Premature T Cell Senescence in Pediatric CKD

(2016) Roshan P. George et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Depletion of Gut Microbiota Protects against Renal Ischemia-Reperfusion Injury

(2016) Diba Emal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Of Inflammasomes and Alarmins: IL-1  and IL-1  in Kidney Disease

(2016) H.-J. Anders   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal dendritic cells sample blood-borne antigen and guide T-cell migration to the kidney by means of intravascular processes

(2016) Karim M. Yatim et al.   KIDNEY INTERNATIONAL

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

(2016) Isis Ludwig-Portugall et al.   KIDNEY INTERNATIONAL

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Cellular senescence in renal ageing and disease

(2016) Ines Sturmlechner et al.   Nature Reviews Nephrology

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

(2016) Arne N. Akbar et al.   TRENDS IN IMMUNOLOGY

Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

(2016) Slim Fourati et al.   Nature Communications

Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come Together

(2016) Gareth W. Jones et al.   Frontiers in Immunology

Inducible Bronchus-Associated Lymphoid Tissue: Taming Inflammation in the Lung

(2016) Ji Young Hwang et al.   Frontiers in Immunology

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment

(2016) Larisa V. Kovtonyuk et al.   Frontiers in Immunology

Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans

(2016) Shai S. Shen-Orr et al.   Cell Systems

The aged lymphoid tissue environment fails to support naïve T cell homeostasis

(2016) Bryan R. Becklund et al.   Scientific Reports

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

(2015) Talibah U. Metcalf et al.   AGING CELL

ATG-Induced Accelerated Immune Senescence: Clinical Implications in Renal Transplant Recipients

(2015) T. Crepin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells

(2015) Jianpeng Sheng et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Macrophage depletion ameliorates nephritis induced by pathogenic antibodies

(2015) Samantha A. Chalmers et al.   JOURNAL OF AUTOIMMUNITY

A CD153+CD4+T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production

(2015) Suhail Tahir et al.   JOURNAL OF IMMUNOLOGY

Fibroblastic Reticular Cells: Organization and Regulation of the T Lymphocyte Life Cycle

(2015) Flavian D. Brown et al.   JOURNAL OF IMMUNOLOGY

Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

(2015) Kira Rubtsova et al.   JOURNAL OF IMMUNOLOGY

Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis

(2015) K. Takaori et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion

(2015) V. Andrade-Oliveira et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory

(2015) Keisuke Yoshida et al.   NATURE IMMUNOLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

(2015) David A. Ferenbach et al.   Nature Reviews Nephrology

Distinguishing age-related from disease-related glomerulosclerosis on kidney biopsy: the Aging Kidney Anatomy study

(2015) Walter K. Kremers et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Stromal infrastructure of the lymph node and coordination of immunity

(2015) Jonathan E. Chang et al.   TRENDS IN IMMUNOLOGY

Exit Strategies: S1P Signaling and T Cell Migration

(2015) Audrey Baeyens et al.   TRENDS IN IMMUNOLOGY

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

(2015) Peter T. Sage et al.   Cell Reports

Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection

(2015) Justin M. Richner et al.   PLoS Pathogens

Heterologous immunity between viruses

(2015) Raymond M. Welsh et al.   IMMUNOLOGICAL REVIEWS

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Lymphatic vessels and tertiary lymphoid organs

(2014) Nancy H. Ruddle   JOURNAL OF CLINICAL INVESTIGATION

Progressive replacement of embryo-derived cardiac macrophages with age

(2014) Kaaweh Molawi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCL5 Drives Neutrophil Recruitment in TH17-Mediated GN

(2014) E. M. Disteldorf et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury

(2014) S. C. Huen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges

(2014) Peter Aaby et al.   NATURE IMMUNOLOGY

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells

(2014) Viviana Cremasco et al.   NATURE IMMUNOLOGY

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dendritic cells and macrophages in the kidney: a spectrum of good and evil

(2014) Natasha M. Rogers et al.   Nature Reviews Nephrology

Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults

(2014) Carlos A. DiazGranados et al.   NEW ENGLAND JOURNAL OF MEDICINE

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

The Menin–Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis

(2014) Makoto Kuwahara et al.   Nature Communications

The Association Between Age and Nephrosclerosis on Renal Biopsy Among Healthy Adults

(2013) Andrew D. Rule   ANNALS OF INTERNAL MEDICINE

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

Impaired B lymphopoiesis in old age: a role for inflammatory B cells?

(2013) Richard L. Riley   IMMUNOLOGIC RESEARCH

How T follicular helper cells and the germinal centre response change with age

(2013) Michelle A Linterman   IMMUNOLOGY AND CELL BIOLOGY

Two Separate Defects Affecting True Naive or Virtual Memory T Cell Precursors Combine To Reduce Naive T Cell Responses with Aging

(2013) K. R. Renkema et al.   JOURNAL OF IMMUNOLOGY

The Pathogenesis of Lupus Nephritis

(2013) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease

(2013) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Understanding immunosenescence to improve responses to vaccines

(2013) Jörg J Goronzy et al.   NATURE IMMUNOLOGY

Immune cell dysfunction and inflammation in end-stage renal disease

(2013) Michiel G. H. Betjes   Nature Reviews Nephrology

Living and dying for inflammation: neutrophils, eosinophils, basophils

(2013) Barbara Geering et al.   TRENDS IN IMMUNOLOGY

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

(2013) Andrea Schietinger et al.   TRENDS IN IMMUNOLOGY

The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency

(2013) Jörg J. Goronzy et al.   Frontiers in Immunology

The Effect of Age on Thymic Function

(2013) Donald B. Palmer   Frontiers in Immunology

The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice

(2012) Julie S. Lefebvre et al.   AGING CELL

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

(2012) Anna C. Hearps et al.   AGING CELL

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

B-1 B Cell Development in the Fetus and Adult

(2012) Encarnacion Montecino-Rodriguez et al.   IMMUNITY

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion

(2012) Shrikant R. Mulay et al.   JOURNAL OF CLINICAL INVESTIGATION

Fc RIIb on Myeloid Cells and Intrinsic Renal Cells Rather than B Cells Protects from Nephrotoxic Nephritis

(2012) P. E. H. Sharp et al.   JOURNAL OF IMMUNOLOGY

Basic and Translational Concepts of Immune-Mediated Glomerular Diseases

(2012) W. G. Couser   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice

(2012) David A. Ferenbach et al.   KIDNEY INTERNATIONAL

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Gut microbiota composition correlates with diet and health in the elderly

(2012) Marcus J. Claesson et al.   NATURE

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Monocyte subpopulations and cardiovascular risk in chronic kidney disease

(2012) Gunnar H. Heine et al.   Nature Reviews Nephrology

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Pathogenic features of CD4+CD28– T cells in immune disorders

(2012) Bieke Broux et al.   TRENDS IN MOLECULAR MEDICINE

Pioneering immunology: insect style

(2011) Moria C Chambers et al.   CURRENT OPINION IN IMMUNOLOGY

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

(2011) Nariaki Asada et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells

(2011) B. L. Esplin et al.   JOURNAL OF IMMUNOLOGY

Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury

(2011) T. Kimura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

(2011) S. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Premature aging of circulating T cells in patients with end-stage renal disease

(2011) Michiel G.H. Betjes et al.   KIDNEY INTERNATIONAL

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonal

(2011) J. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions

(2011) B. D. Rudd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory markers in population studies of aging

(2010) Tushar Singh et al.   AGEING RESEARCH REVIEWS

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Effect of Different Dialysis Modalities on Microinflammatory Status and Endothelial Damage

(2010) A. Merino et al.   Clinical Journal of the American Society of Nephrology

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

(2010) A. A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage Wnt7b is critical for kidney repair and regeneration

(2010) S.-L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Interleukin 17 Promotes Angiotensin II–Induced Hypertension and Vascular Dysfunction

(2009) Meena S. Madhur et al.   HYPERTENSION

Bone Marrow Ly6Chigh Monocytes Are Selectively Recruited to Injured Kidney and Differentiate into Functionally Distinct Populations

(2009) S. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Age‐Associated Inflammation and Toll‐Like Receptor Dysfunction Prime the Lungs for Pneumococcal Pneumonia

(2009) Ernesto Hinojosa et al.   JOURNAL OF INFECTIOUS DISEASES

Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis

(2009) D A Hill et al.   Mucosal Immunology

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation

(2009) Serge A van de Pavert et al.   NATURE IMMUNOLOGY

Rejuvenating the immune system in rheumatoid arthritis

(2009) Cornelia M. Weyand et al.   Nature Reviews Rheumatology

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infections and autoimmunity – friends or foes?

(2009) Shaye Kivity et al.   TRENDS IN IMMUNOLOGY

An evolutionary perspective on the mechanisms of immunosenescence

(2009) Daryl P. Shanley et al.   TRENDS IN IMMUNOLOGY

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY

Skin Cancer in Organ Transplant Recipients-Where Do We Stand Today?

(2008) C. Ulrich et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

Exploring the complex relations between inflammation and aging (inflamm-aging): anti-inflamm-aging remodelling of inflamm- aging, from robustness to frailty

(2008) G. Sergio   INFLAMMATION RESEARCH

Zag Expression during Aging Suppresses Proliferation after Kidney Injury

(2008) R. Schmitt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Acute Kidney Injury Increases Risk of ESRD among Elderly

(2008) A. Ishani et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Analysis and classification of B-cell infiltrates in lupus and ANCA-associated nephritis

(2008) Oliver M. Steinmetz et al.   KIDNEY INTERNATIONAL

Expansion of cytolytic CD4+CD28− T cells in end-stage renal disease

(2008) Michiel G.H. Betjes et al.   KIDNEY INTERNATIONAL

Monitoring cellular movement in vivo with photoconvertible fluorescence protein "Kaede" transgenic mice

(2008) M. Tomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells

(2008) J. M. Gardner et al.   SCIENCE

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

(2007) Antero Salminen et al.   AGEING RESEARCH REVIEWS