Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?

Relation of the degree of obesity in childhood to adipose tissue insulin resistance

(2019) Emilia Hagman et al.   ACTA DIABETOLOGICA

Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells

(2019) Stefanie Bader et al.   PSYCHONEUROENDOCRINOLOGY

Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice

(2019) Susana Castelo Branco Ramos Nakandakari et al.   BRAIN BEHAVIOR AND IMMUNITY

In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice

(2019) Jenny Sandström et al.   ARCHIVES OF TOXICOLOGY

Priming Microglia for Innate Immune Memory in the Brain

(2019) Jonas J. Neher et al.   TRENDS IN IMMUNOLOGY

Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer’s disease by remodeling peri-plaque astrocyte structure

(2019) Alex J. Smith et al.   Acta Neuropathologica Communications

Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer’s disease by restoring microglial function via a PPAR-γ-dependent mechanism

(2019) Elisa Medrano-Jiménez et al.   Journal of Neuroinflammation

11β-HSD1 Inhibition Rescues SAMP8 Cognitive Impairment Induced by Metabolic Stress

(2019) Dolors Puigoriol-Illamola et al.   MOLECULAR NEUROBIOLOGY

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

(2019) Michael Ewers et al.   Science Translational Medicine

The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer’s Dementia

(2019) Jaume Folch et al.   Frontiers in Aging Neuroscience

Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species

(2019) Xu-Qiao Chen et al.   Frontiers in Neuroscience

Exenatide Reverts the High-Fat-Diet-Induced Impairment of BDNF Signaling and Inflammatory Response in an Animal Model of Alzheimer’s Disease

(2019) Manuela Bomba et al.   JOURNAL OF ALZHEIMERS DISEASE

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Adaptive immunity: an emerging player in the progression of NAFLD

(2019) Salvatore Sutti et al.   Nature Reviews Gastroenterology & Hepatology

How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases

(2019) Wolfgang Kopp   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment

(2018) Igor Pomytkin et al.   CNS Neuroscience & Therapeutics

TSPO–PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington’s disease: preclinical evidence with the p75NTR ligand LM11A-31

(2018) Danielle A Simmons et al.   HUMAN MOLECULAR GENETICS

Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models

(2018) Slava Rom et al.   MOLECULAR NEUROBIOLOGY

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

(2018) Mark A. Petersen et al.   NATURE REVIEWS NEUROSCIENCE

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment

(2018) Dunja Knezevic et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer's disease and the possible mechanisms in CHO-APP/PS1 cells and SAMP8 mice

(2018) Hongxia Che et al.   Food & Function

TLR4-NF-κB Signal Involved in Depressive-Like Behaviors and Cytokine Expression of Frontal Cortex and Hippocampus in Stressed C57BL/6 and ob/ob Mice

(2018) Yihe Wang et al.   NEURAL PLASTICITY

Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits

(2018) Shreyasi Chatterjee et al.   Frontiers in Neuroscience

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

(2018) Cyril Laurent et al.   Biomedical Journal

Adipose tissue inflammation and metabolic syndrome. The proactive role of probiotics

(2018) Sebastian Torres et al.   EUROPEAN JOURNAL OF NUTRITION

Properties and functions of adipose tissue macrophages in obesity

(2018) Lucia Russo et al.   IMMUNOLOGY

Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation

(2018) Yi-Heng Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease

(2018) Estella A. Newcombe et al.   Journal of Neuroinflammation

Insulin transport across the blood-brain barrier can occur independently of the insulin receptor

(2018) Elizabeth M. Rhea et al.   JOURNAL OF PHYSIOLOGY-LONDON

Distinguishing normal brain aging from the development of Alzheimer's disease: inflammation, insulin signaling and cognition

(2018) Paul Denver et al.   Neural Regeneration Research

Soluble TREM2 changes during the clinical course of Alzheimer’s disease: A meta-analysis

(2018) Dan Liu et al.   NEUROSCIENCE LETTERS

What have we learned recently from transgenic mouse models about neurodegeneration? The most promising discoveries of this millennium

(2018) Grzegorz Kreiner   Pharmacological Reports

Chia Seed Does Not Improve Cognitive Impairment in SAMP8 Mice Fed with High Fat Diet

(2018) Yehua Rui et al.   Nutrients

Elucidating the Interactive Roles of Glia in Alzheimer's Disease Using Established and Newly Developed Experimental Models

(2018) Heejung Chun et al.   Frontiers in Neurology

Adipose Tissue Insulin Resistance in Youth on the Spectrum From Normal Weight to Obese and From Normal Glucose Tolerance to Impaired Glucose Tolerance to Type 2 Diabetes

(2018) Joon Young Kim et al.   DIABETES CARE

Obesity and dysregulated central and peripheral macrophage-neuron cross-talk

(2018) Sigalit Boura-Halfon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type 2 Diabetes Mellitus and Alzheimer’s Disease: Role of Insulin Signalling and Therapeutic Implications

(2018) Andrea Tumminia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity

(2018) V. Alexandra Moser et al.   Journal of Neuroinflammation

Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology

(2018) Martina Holubová et al.   NEUROPHARMACOLOGY

Tau monomer encodes strains

(2018) Apurwa M Sharma et al.   eLife

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease

(2018) Mikael Marttinen et al.   Frontiers in Neuroscience

Microglia in Alzheimer's Disease: Risk Factors and Inflammation

(2018) Atsuko Katsumoto et al.   Frontiers in Neurology

The impact of anorexigenic peptides in experimental models of Alzheimer’s disease pathology

(2018) Lenka Maletínská et al.   JOURNAL OF ENDOCRINOLOGY

A state of delirium: Deciphering the effect of inflammation on tau pathology in Alzheimer's disease

(2017) Matthew Barron et al.   EXPERIMENTAL GERONTOLOGY

An Updated View of Translocator Protein (TSPO)

(2017) Nunzio Denora et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tau Oligomers in Sera of Patients with Alzheimer’s Disease and Aged Controls

(2017) Michala Kolarova et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

(2017) Sam Horng et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Tau deletion promotes brain insulin resistance

(2017) Elodie Marciniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

M1 Means Kill; M2 Means Heal

(2017) Klaus Ley   JOURNAL OF IMMUNOLOGY

The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications

(2017) Anna Alisi et al.   MEDIATORS OF INFLAMMATION

Practical considerations for choosing a mouse model of Alzheimer’s disease

(2017) Joanna L. Jankowsky et al.   Molecular Neurodegeneration

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers

(2017) Kaitlin B. Casaletto et al.   NEUROLOGY

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome

(2017) Gema Frühbeck et al.   Scientific Reports

Widespread tau seeding activity at early Braak stages

(2016) Jennifer L. Furman et al.   ACTA NEUROPATHOLOGICA

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels

(2016) Henry H. Ruiz et al.   Alzheimers & Dementia

Glial influences on BBB functions and molecular players in immune cell trafficking

(2016) Marc-André Lécuyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Adiponectin, TNF-α and inflammatory cytokines and risk of type 2 diabetes: A systematic review and meta-analysis

(2016) Chenxiao Liu et al.   CYTOKINE

Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer’s Disease

(2016) Suzanne M. de la Monte   DRUGS

Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases

(2016) Ashley N. Nilson et al.   JOURNAL OF ALZHEIMERS DISEASE

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

(2016) Molly Stanley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

(2016) Do-Geun Kim et al.   Journal of Neuroinflammation

The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice

(2016) Molly Stanley et al.   JOURNAL OF NEUROSCIENCE

APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease

(2016) G. D. Manocha et al.   JOURNAL OF NEUROSCIENCE

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice

(2016) Noura B. El Khoury et al.   NEUROBIOLOGY OF DISEASE

The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice

(2016) Carola I. F. Janssen et al.   PLoS One

Early changes in CSF sTREM2 in dominantly inherited Alzheimers disease occur after amyloid deposition and neuronal injury

(2016) M. Suarez-Calvet et al.   Science Translational Medicine

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

(2015) Hlin Kvartsberg et al.   Alzheimers & Dementia

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

(2015) Elly M Hol et al.   CURRENT OPINION IN CELL BIOLOGY

Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPKSer-485Phosphorylation

(2015) Bhumsoo Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

(2015) Tamás Rőszer   MEDIATORS OF INFLAMMATION

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice

(2015) Chi-Wen Yeh et al.   NEUROBIOLOGY OF AGING

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Models and mechanisms for hippocampal dysfunction in obesity and diabetes

(2015) A.M. Stranahan   NEUROSCIENCE

Macrophage recruitment in obese adipose tissue

(2015) Y. Bai et al.   Obesity Reviews

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

(2015) Jae Kyu Ryu et al.   Nature Communications

Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer’s disease patients and healthy controls

(2015) Hlin Kvartsberg et al.   Alzheimers Research & Therapy

Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity

(2015) Nathalie Castanon et al.   Frontiers in Neuroscience

The Role of Ion Channels in Microglial Activation and Proliferation – A Complex Interplay between Ligand-Gated Ion Channels, K+ Channels, and Intracellular Ca2+

(2015) Martin James Stebbing et al.   Frontiers in Immunology

Autoregulated paracellular clearance of amyloid-  across the blood-brain barrier

(2015) J. Keaney et al.   Science Advances

The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier?

(2015) Tina Sartorius et al.   PLoS One

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies

(2014) Mark Yarchoan et al.   ACTA NEUROPATHOLOGICA

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?

(2014) Pooja Naik et al.   BMC NEUROSCIENCE

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Insulin Reverses the High-Fat Diet-Induced Increase in Brain A  and Improves Memory in an Animal Model of Alzheimer Disease

(2014) M. Vandal et al.   DIABETES

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Decoding insulin resistance and metabolic syndrome for promising therapeutic intervention

(2014) Shaodong Guo   JOURNAL OF ENDOCRINOLOGY

Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia

(2014) Yali Wang et al.   JOURNAL OF NEUROCHEMISTRY

Adipokines: a link between obesity and dementia?

(2014) Amanda J Kiliaan et al.   LANCET NEUROLOGY

Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models

(2014) Lindsay A. Hohsfield et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Insulin resistance in Alzheimer's disease

(2014) Kelly T. Dineley et al.   NEUROBIOLOGY OF DISEASE

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic characterization of human proinflammatory M1 and anti-inflammatory M2 macrophages and their response toCandida albicans

(2014) Jose Antonio Reales-Calderón et al.   PROTEOMICS

Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice

(2014) Juan Jose Ramos-Rodriguez et al.   PSYCHONEUROENDOCRINOLOGY

High Activities of BACE1 in Brains with Mild Cognitive Impairment

(2013) Xin Cheng et al.   AMERICAN JOURNAL OF PATHOLOGY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1  Antibody, in Patients With Type 2 Diabetes

(2013) J. Sloan-Lancaster et al.   DIABETES CARE

Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation

(2013) Dora Lippai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microglial Phenotype and Adaptation

(2013) B. J. L. Eggen et al.   Journal of Neuroimmune Pharmacology

Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele

(2013) Hiramani Dhungana et al.   Journal of Neuroinflammation

Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease

(2013) Alberto Serrano-Pozo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Prefibrillar Tau Oligomers in Mild Cognitive Impairment and Alzheimer's Disease

(2013) Elliott J. Mufson et al.   Neurodegenerative Diseases

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Macrophage Polarisation: an Immunohistochemical Approach for Identifying M1 and M2 Macrophages

(2013) Mário Henrique M. Barros et al.   PLoS One

Expression of Tau40 Induces Activation of Cultured Rat Microglial Cells

(2013) Lu Wang et al.   PLoS One

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

(2013) V. Hugh Perry et al.   Seminars in Immunopathology

A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer's brain tissues

(2013) Jun-ichi Satoh et al.   Alzheimers Research & Therapy

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Metabolic syndrome, mild cognitive impairment and Alzheimer's disease—The emerging role of systemic low-grade inflammation and adiposity

(2012) Blazej Misiak et al.   BRAIN RESEARCH BULLETIN

The SAMP8 Mouse: A Model to Develop Therapeutic Interventions for Alzheimers Disease

(2012) John E. Morley et al.   CURRENT PHARMACEUTICAL DESIGN

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit

(2012) Jérôme Badaut et al.   Journal of Neuroinflammation

A 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling

(2012) S.-Y. Kook et al.   JOURNAL OF NEUROSCIENCE

Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease

(2012) J. L. Furman et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs

(2012) Konstantin Stark et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Neuroinflammation and Blood-Brain Barrier Changes in Capillary Amyloid Angiopathy

(2012) Anna Carrano et al.   Neurodegenerative Diseases

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis

(2012) Deepak Kumar Kaushik et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Multiple cellular and molecular mechanisms Are involved in human Aβ clearance by transplanted adult astrocytes

(2011) Rea Pihlaja et al.   GLIA

A Common Pathogenic Mechanism Linking Type-2 Diabetes and Alzheimer's Disease: Evidence from Animal Models

(2011) Sun Ah Park   Journal of Clinical Neurology

Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-  Expression for Microglial A  Phagocytosis

(2011) D. Terwel et al.   JOURNAL OF NEUROSCIENCE

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice

(2011) Mian Bi et al.   PLoS One

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Macrophage Colony-Stimulating Factor (M-CSF) in Plasma and CSF of Patients with Mild Cognitive Impairment and Alzheimers Disease

(2010) C. Laske et al.   Current Alzheimer Research

Effects of the Dietary Approaches to Stop Hypertension Diet, Exercise, and Caloric Restriction on Neurocognition in Overweight Adults With High Blood Pressure

(2010) Patrick J. Smith et al.   HYPERTENSION

Nuclear Tau, a Key Player in Neuronal DNA Protection

(2010) Audrey Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Reactive astrocytes give neurons less support: implications for Alzheimer's disease

(2010) Megan L. Steele et al.   NEUROBIOLOGY OF AGING

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thrombin Mediates Severe Neurovascular Injury During Ischemia

(2010) Bo Chen et al.   STROKE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Interferon-γ Differentially Affects Alzheimer’s Disease Pathologies and Induces Neurogenesis in Triple Transgenic-AD Mice

(2009) Michael A. Mastrangelo et al.   AMERICAN JOURNAL OF PATHOLOGY

Pathophysiology of type 2 diabetes mellitus in youth: the evolving chameleon

(2009) Hala Tfayli et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Inflammation in transgenic mouse models of neurodegenerative disorders

(2009) Claudia Schwab et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders

(2009) Louis A. Profenno et al.   BIOLOGICAL PSYCHIATRY

APP transgenic modeling of Alzheimer’s disease: mechanisms of neurodegeneration and aberrant neurogenesis

(2009) Leslie Crews et al.   Brain Structure & Function

Lipopolysaccharide-Activated Microglia Induce Dysfunction of the Blood–Brain Barrier in Rat Microvascular Endothelial Cells Co-Cultured with Microglia

(2009) Noriko Sumi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Interferon γ Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway

(2009) Fiona C. McGillicuddy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

(2009) Yang Yu et al.   JOURNAL OF NEUROCHEMISTRY

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology

(2008) Randall S. Frey et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH oxidase as a therapeutic target in Alzheimer's disease

(2008) Michelle L Block   BMC NEUROSCIENCE

Adipokines: The missing link between insulin resistance and obesity

(2008) B. Antuna-Puente et al.   DIABETES & METABOLISM

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Differential effects of hydrocortisone and TNFα on tight junction proteins in anin vitromodel of the human blood-brain barrier

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