Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models

PGLP-1, a novel long-acting dual-function GLP-1 analog, ameliorates streptozotocin-induced hyperglycemia and inhibits body weight loss

(2017) Huashan Gao et al.   FASEB JOURNAL

Epidemiological Approaches to Understanding the Link Between Type 2 Diabetes and Dementia

(2017) Greg T. Sutherland et al.   JOURNAL OF ALZHEIMERS DISEASE

Blood Brain Barrier Injury in Diabetes: Unrecognized Effects on Brain and Cognition

(2017) Marina Bogush et al.   Journal of Neuroimmune Pharmacology

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype

(2017) Shorena Janelidze et al.   NEUROBIOLOGY OF AGING

Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link

(2017) Ryusuke Takechi et al.   Frontiers in Aging Neuroscience

Cerebral Pathology and Cognition in Diabetes: The Merits of Multiparametric Neuroimaging

(2017) Frank C. G. van Bussel et al.   Frontiers in Neuroscience

Cerebrospinal fluid matrix metalloproteinase 9 levels, blood-brain barrier permeability, and treatment outcome in tuberculous meningitis

(2017) Sharada Mailankody et al.   PLoS One

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

(2016) Amy R. Nelson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction

(2016) Ying Cui et al.   Brain Imaging and Behavior

Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice

(2016) Wilma Helena Oliveira et al.   BRAIN RESEARCH

Diagnostic utility of VEGF and soluble CD40L levels in serum of Alzheimer's patients

(2016) Shu Yu et al.   CLINICA CHIMICA ACTA

Breakdown of the Cerebrovasculature and Blood-Brain Barrier: A Mechanistic Link Between Diabetes Mellitus and Alzheimer’s Disease

(2016) Eric L. Goldwaser et al.   JOURNAL OF ALZHEIMERS DISEASE

Blood–brain barrier breakdown promotes macrophage infiltration and cognitive impairment in leptin receptor-deficient mice

(2016) Alexis M Stranahan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Angiographic evidence of proliferative retinopathy predicts neuropsychiatric morbidity in diabetic patients

(2016) Yonatan Serlin et al.   PSYCHONEUROENDOCRINOLOGY

RNA extraction for RNA sequencing of archival renal tissues

(2016) Lea Landolt et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy

(2016) C. Moran et al.   Journal of Diabetes Research

Astrocytic TYMP and VEGFA drive blood–brain barrier opening in inflammatory central nervous system lesions

(2015) Candice Chapouly et al.   BRAIN

Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study

(2015) Martin Heier et al.   Cardiovascular Diabetology

Are reactive oxygen species still the basis for diabetic complications?

(2015) Elyse Di Marco et al.   CLINICAL SCIENCE

Dysfunction of brain pericytes in chronic neuroinflammation

(2015) Yuri Persidsky et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

miR-98 and let-7g* Protect the Blood-Brain Barrier Under Neuroinflammatory Conditions

(2015) Slava Rom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TGFβ1 exacerbates blood–brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5

(2015) Matthew A McMillin et al.   LABORATORY INVESTIGATION

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

The Safety of the Blood Supply — Time to Raise the Bar

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

High glucose, glucose fluctuation and carbonyl stress enhance brain microvascular endothelial barrier dysfunction: Implications for diabetic cerebral microvasculature

(2015) Wei Li et al.   Redox Biology

Poly(ADP-ribose) Polymerase-1 Inhibition in Brain Endothelium Protects the Blood—Brain Barrier under Physiologic and Neuroinflammatory Conditions

(2014) Slava Rom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Emerging Roles of Pericytes in the Regulation of the Neurovascular Unit in Health and Disease

(2014) Jeremy Hill et al.   Journal of Neuroimmune Pharmacology

Comparison of Two Methods of RNA Extraction from Formalin-Fixed Paraffin-Embedded Tissue Specimens

(2014) Gisele Rodrigues Gouveia et al.   Biomed Research International

Type 2 diabetes as a risk factor for cognitive impairment: current insights

(2014) Hiroyuki Umegaki   Clinical Interventions in Aging

High glucose-induced mitochondrial respiration and reactive oxygen species in mouse cerebral pericytes is reversed by pharmacological inhibition of mitochondrial carbonic anhydrases: Implications for cerebral microvascular disease in diabetes

(2013) Gul N. Shah et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative stress in diabetes – circulating advanced glycation end products, lipid oxidation and vascular disease

(2013) Irundika HK Dias et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Suppression of GLUT1; A new strategy to prevent diabetic complications

(2012) Lili Lu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of Cannabinoid Receptor 2 Attenuates Leukocyte-Endothelial Cell Interactions and Blood-Brain Barrier Dysfunction under Inflammatory Conditions

(2012) S. H. Ramirez et al.   JOURNAL OF NEUROSCIENCE

Effective DNA/RNA Co-Extraction for Analysis of MicroRNAs, mRNAs, and Genomic DNA from Formalin-Fixed Paraffin-Embedded Specimens

(2012) Adam Kotorashvili et al.   PLoS One

Excess Soluble CD40L Contributes to Blood Brain Barrier Permeability In Vivo: Implications for HIV-Associated Neurocognitive Disorders

(2012) Donna C. Davidson et al.   PLoS One

Does cerebral small vessel disease predict future decline of cognitive function in elderly people with type 2 diabetes?

(2011) Rui Imamine et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease

(2011) Jean-Philippe Michaud et al.   Molecular Neurodegeneration

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice

(2011) Kelley Bromley-Brits et al.   Jove-Journal of Visualized Experiments

Comparison of methods in the recovery of nucleic acids from archival formalin-fixed paraffin-embedded autopsy tissues

(2010) John B.A. Okello et al.   ANALYTICAL BIOCHEMISTRY

Pitavastatin and 4-Hydroxy-3-Methoxyacetophenone (HMAP) Reduce Cognitive Dysfunction in Vascular Dementia During Experimental Diabetes

(2010) Bhupesh Sharma et al.   CURRENT NEUROVASCULAR RESEARCH

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Neurodegeneration and the neurovascular unit

(2010) Berislav V Zlokovic   NATURE MEDICINE

Relationship Between Baseline Glycemic Control and Cognitive Function in Individuals With Type 2 Diabetes and Other Cardiovascular Risk Factors: The Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) trial

(2009) T. Cukierman-Yaffe et al.   DIABETES CARE

Signaling to P-glycoprotein - A new therapeutic target to treat drug-resistant epilepsy

(2009) A.M.S. Hartz et al.   DRUG NEWS & PERSPECTIVES

Soluble CD40 ligand in dementia

(2009) B. Giunta et al.   DRUGS OF THE FUTURE

Hypoglycemic Episodes and Risk of Dementia in Older Patients With Type 2 Diabetes Mellitus

(2009) Rachel A. Whitmer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Occludin Phosphorylation and Ubiquitination Regulate Tight Junction Trafficking and Vascular Endothelial Growth Factor-induced Permeability

(2009) Tomoaki Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON