Type 2 Diabetes Mellitus and Alzheimer’s Disease: Role of Insulin Signalling and Therapeutic Implications

Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice

(2018) Paul Denver et al.   BRAIN BEHAVIOR AND IMMUNITY

ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression- and anxiety-related symptoms in a rat model of Alzheimer's disease

(2018) Mohammad Hossein Esmaeili et al.   BRAIN RESEARCH BULLETIN

Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment

(2018) Igor Pomytkin et al.   CNS Neuroscience & Therapeutics

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Incidence of Dementia is Increased in Type 2 Diabetes and Reduced by the Use of Sulfonylureas and Metformin

(2018) Chih-Cheng Hsu et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes

(2018) Tze Pin Ng et al.   JOURNAL OF ALZHEIMERS DISEASE

Distinguishing normal brain aging from the development of Alzheimer's disease: inflammation, insulin signaling and cognition

(2018) Paul Denver et al.   Neural Regeneration Research

Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1–42

(2018) Alfonso Diaz et al.   Oxidative Medicine and Cellular Longevity

Links Between Obesity-Induced Brain Insulin Resistance, Brain Mitochondrial Dysfunction, and Dementia

(2018) Jirapas Sripetchwandee et al.   Frontiers in Endocrinology

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

(2017) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial

(2017) Suzanne Craft et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuropsychiatric Symptoms in Alzheimer Disease, Vascular Dementia, and Mixed Dementia

(2017) Cassandra J. Anor et al.   Neurodegenerative Diseases

Late-Onset Alzheimer Disease

(2017) Aimee L. Pierce et al.   NEUROLOGIC CLINICS

Antidiabetic Drugs in Alzheimer’s Disease: Mechanisms of Action and Future Perspectives

(2017) Grazia Daniela Femminella et al.   Journal of Diabetes Research

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

(2016) Henrik H. Hansen et al.   BRAIN RESEARCH

Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer’s Disease

(2016) Suzanne M. de la Monte   DRUGS

Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction

(2016) Ming-Chang Chiang et al.   EXPERIMENTAL CELL RESEARCH

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Communication from the periphery to the hypothalamus through the blood–brain barrier: An in vitro platform

(2016) João Pedro Martins et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

(2016) José A. Luchsinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Liraglutide prevents beta-amyloid-induced neurotoxicity in SH-SY5Y cells via a PI3K-dependent signaling pathway

(2016) Xiao-Ying Liu et al.   NEUROLOGICAL RESEARCH

Glimepiride protects neurons against amyloid-β-induced synapse damage

(2016) Craig Osborne et al.   NEUROPHARMACOLOGY

In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Michael Gejl et al.   Frontiers in Aging Neuroscience

The Effect of Diabetes Medication on Cognitive Function: Evidence from the PATH Through Life Study

(2016) Pushpani M. Herath et al.   Biomed Research International

Insulin, insulin receptors, and cancer

(2016) R. Vigneri et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependent

(2015) Ming-Min Chung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through Activation of AMPK in Neuronal Cells

(2015) Edy Kornelius et al.   CNS Neuroscience & Therapeutics

The peroxisome proliferators activated receptor-gamma agonists as therapeutics for the treatment of Alzheimer's disease and mild-to-moderate Alzheimer's disease: a meta-analysis

(2015) Huawei Cheng et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Alzheimer’s disease and type 2 diabetes via chronic inflammatory mechanisms

(2015) Gohar Mushtaq et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

(2015) Simon C. Cork et al.   Molecular Metabolism

Insulin, Aging, and the Brain: Mechanisms and Implications

(2015) Abimbola A. Akintola et al.   Frontiers in Endocrinology

Tau aggregation and its interplay with amyloid-β

(2014) Rebecca M. Nisbet et al.   ACTA NEUROPATHOLOGICA

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus

(2014) Min Guo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Insulin Reverses the High-Fat Diet-Induced Increase in Brain A  and Improves Memory in an Animal Model of Alzheimer Disease

(2014) M. Vandal et al.   DIABETES

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice

(2014) Yang Yu et al.   JOURNAL OF NEURAL TRANSMISSION

Dipeptidyl Peptidase-4 Inhibitors Have Protective Effect on Cognitive Impairment in Aged Diabetic Patients With Mild Cognitive Impairment

(2014) M. R. Rizzo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis

(2014) Chin Cheng et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

New drug treatments show neuroprotective effects in Alzheimer′s and Parkinson′s diseases

(2014) Christian Hölscher   Neural Regeneration Research

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide

(2014) Krzysztof Łabuzek et al.   Pharmacological Reports

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

(2013) E. M. Moore et al.   DIABETES CARE

Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease

(2013) Jayasankar Kosaraju et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Saxagliptin: A dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease

(2013) Jayasankar Kosaraju et al.   NEUROPHARMACOLOGY

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

(2013) Paula L. McClean et al.   NEUROPHARMACOLOGY

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

(2013) Amanda L. Wright et al.   PLoS One

Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions

(2013) Geert Jan Biessels et al.   Lancet Diabetes & Endocrinology

Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis

(2013) Marianna Sadagurski et al.   Molecular Metabolism

Intracerebroventricular administration of an insulin analogue recovers STZ-induced cognitive decline in rats

(2012) Akiko Sheala Shingo et al.   BEHAVIOURAL BRAIN RESEARCH

Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

(2012) Kerry Hunter et al.   BMC NEUROSCIENCE

Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood–brain barrier: Protection by the antioxidant N-acetylcysteine

(2012) Michelle A. Erickson et al.   BRAIN BEHAVIOR AND IMMUNITY

Finding a pathological diagnosis for Alzheimer's disease: Are inflammatory molecules the answer?

(2012) Manraj S. Bhamra et al.   ELECTROPHORESIS

Protective Effects of Beta Glucan and Gliclazide on Brain Tissue and Sciatic Nerve of Diabetic Rats Induced by Streptozosin

(2012) Harun Alp et al.   Experimental Diabetes Research

Insulin Promotes Neuronal Survival via the Alternatively Spliced Protein Kinase CδII Isoform

(2012) André Apostolatos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus

(2012) Muhammad Sajid Hamid Akash et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study

(2012) Patrick Imfeld et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

(2012) Jiejie Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

(2011) Amit Gupta et al.   NEUROPHARMACOLOGY

A Randomized Pilot Clinical Trial of the Safety of Pioglitazone in Treatment of Patients With Alzheimer Disease

(2010) David S. Geldmacher et al.   ARCHIVES OF NEUROLOGY

Ubiquitin-like protein MNSFβ/endophilin II complex regulates Dectin-1-mediated phagocytosis and inflammatory responses in macrophages

(2010) Morihiko Nakamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Incretin-Based Therapies for the Treatment of Type 2 Diabetes: Evaluation of the Risks and Benefits

(2010) D. J. Drucker et al.   DIABETES CARE

How does diabetes accelerate Alzheimer disease pathology?

(2010) Catrina Sims-Robinson et al.   Nature Reviews Neurology

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease

(2009) Tomohiko Sato et al.   NEUROBIOLOGY OF AGING

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monocyte Chemoattractant Protein-1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease

(2008) Anna Sokolova et al.   BRAIN PATHOLOGY

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL