Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer’s Disease

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Limited Alzheimer-Type Neurodegeneration in Experimental Obesity and Type 2 Diabetes Mellitus

(2017) Natalie Moroz et al.   JOURNAL OF ALZHEIMERS DISEASE

Epidemiological Trends Strongly Suggest Exposures as Etiologic Agents in the Pathogenesis of Sporadic Alzheimer's Disease, Diabetes Mellitus, and Non-Alcoholic Steatohepatitis

(2017) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanisms of Nitrosamine-Mediated Neurodegeneration: Potential Relevance to Sporadic Alzheimer's Disease

(2017) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

Hepatic Ceramide May Mediate Brain Insulin Resistance and Neurodegeneration in Type 2 Diabetes and Non-alcoholic Steatohepatitis

(2017) Lascelles E. Lyn-Cook et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain Insulin-Like Growth Factor and Neurotrophin Resistance in Parkinson's Disease and Dementia with Lewy Bodies: Potential Role of Manganese Neurotoxicity

(2017) Ming Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

Lithium Treatment Arrests the Development of Neurofibrillary Tangles in Mutant Tau Transgenic Mice with Advanced Neurofibrillary Pathology

(2017) Karelle Leroy et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Iron Metabolism and Its Role in Neurodegeneration

(2017) Maxx P. Horowitz et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer’s disease

(2016) Chengyu Zou et al.   ACTA NEUROPATHOLOGICA

The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies

(2016) Emilio Pedditizi et al.   AGE AND AGEING

PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice

(2016) Junya Toba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

Safety and efficacy of insulin degludec/insulin aspart with bolus mealtime insulin aspart compared with standard basal-bolus treatment in people with Type 1 diabetes: 1-year results from a randomized clinical trial (BOOST® T1)

(2016) I. B. Hirsch et al.   DIABETIC MEDICINE

T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer’s Disease

(2016) Ming Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

Improved Brain Insulin/IGF Signaling and Reduced Neuroinflammation with T3D-959 in an Experimental Model of Sporadic Alzheimer’s Disease

(2016) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

(2016) José A. Luchsinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Tobacco nitrosamines as culprits in disease: mechanisms reviewed

(2016) Emine Yalcin et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Insulin-like growth factor-1 deficiency and metabolic syndrome

(2016) G. A. Aguirre et al.   Journal of Translational Medicine

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment

(2016) Theresa Köbe et al.   NEUROIMAGE

The incretin system ABCs in obesity and diabetes - novel therapeutic strategies for weight loss and beyond

(2016) A. L. João et al.   Obesity Reviews

Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance

(2016) Richard M. Cubbon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Michael Gejl et al.   Frontiers in Aging Neuroscience

Lower rates of hypoglycemia during maintenance treatment with insulin degludec/insulin aspart versus biphasic insulin aspart 30: a combined analysis of two Phase 3a studies in type 2 diabetes

(2016) Jens Sandahl Christiansen et al.   Journal of Diabetes

Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline

(2015) Joana M. Gaspar et al.   ACS Chemical Neuroscience

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

T3D-959: A multi-faceted disease remedial drug candidate for the treatment of Alzheimer's disease

(2015) John Didsbury et al.   Alzheimers & Dementia

Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease

(2015) Kaj Blennow et al.   Alzheimers & Dementia

Emerging Concepts in Alzheimer's Disease

(2015) Harry V. Vinters   Annual Review of Pathology-Mechanisms of Disease

Central Nervous System Regulation of Intestinal Lipoprotein Metabolism by Glucagon-Like Peptide-1 via a Brain-Gut Axis

(2015) S. Farr et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction

(2015) Elisa Navarro et al.   BIOCHEMICAL PHARMACOLOGY

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease

(2015) K. G. Goozee et al.   BRITISH JOURNAL OF NUTRITION

Novel GLP-1 (Glucagon-Like Peptide-1) Analogues and Insulin in the Treatment for Alzheimer’s Disease and Other Neurodegenerative Diseases

(2015) Valeria Calsolaro et al.   CNS DRUGS

DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through Activation of AMPK in Neuronal Cells

(2015) Edy Kornelius et al.   CNS Neuroscience & Therapeutics

Targeting Insulin Signaling for the Treatment of Alzheimer's Disease

(2015) Yanxing Chen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Diabetes, glycaemia, and cognition-a secondary analysis of the Finnish Diabetes Prevention Study

(2015) Jenni Lehtisalo et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Hypothalamic ER stress: A bridge between leptin resistance and obesity

(2015) Sara Ramírez et al.   FEBS LETTERS

Circulating Biomarker Panels in Alzheimer's Disease

(2015) Sachli Zafari et al.   GERONTOLOGY

Regulation of the orexigenic neuropeptide, enkephalin, by PPARδ and fatty acids in neurons of the hypothalamus and forebrain

(2015) Kinning Poon et al.   JOURNAL OF NEUROCHEMISTRY

Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation

(2015) Tarja Malm et al.   Journal of Neuroinflammation

Biomarkers in the diagnosis and management of Alzheimer’s disease

(2015) Richard Wurtman   METABOLISM-CLINICAL AND EXPERIMENTAL

Insulin resistance in Alzheimer disease: Is heme oxygenase-1 an Achille's heel?

(2015) Eugenio Barone et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients

(2015) Paolo Santambrogio et al.   NEUROBIOLOGY OF DISEASE

The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson’s disease

(2015) R.B. Mounsey et al.   NEUROSCIENCE

Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation

(2015) Jared M. Fine et al.   NEUROSCIENCE LETTERS

Leptin applications in 2015

(2015) Olivia M. Farr et al.   Current Opinion in Endocrinology Diabetes and Obesity

In vivo molecular neuroimaging of glucose utilization and its association with fibrillar amyloid-β load in aged APPPS1-21 mice

(2015) Ann-Marie Waldron et al.   Alzheimers Research & Therapy

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

(2015) Xiaohua Li et al.   Clinical Interventions in Aging

The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer

(2015) David Rose et al.   Cancers

Effects of Low Doses of Pioglitazone on Resting-State Functional Connectivity in Conscious Rat Brain

(2015) Donna G. Crenshaw et al.   PLoS One

Anti-Diabetes Drug Pioglitazone Ameliorates Synaptic Defects in AD Transgenic Mice by Inhibiting Cyclin-Dependent Kinase5 Activity

(2015) Jinan Chen et al.   PLoS One

The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

(2014) Christian Hölscher   Alzheimers & Dementia

Brain metabolic dysfunction at the core of Alzheimer's disease

(2014) Suzanne M. de la Monte et al.   BIOCHEMICAL PHARMACOLOGY

Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

(2014) Christian Hölscher   BIOCHEMICAL SOCIETY TRANSACTIONS

Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis

(2014) May A Beydoun et al.   BMC PUBLIC HEALTH

The Negative Effects of Obesity and Poor Glycemic Control on Cognitive Function: A Proposed Model for Possible Mechanisms

(2014) Michael L. Alosco et al.   Current Diabetes Reports

Clearance of Beta-Amyloid in the Brain

(2014) Masaki Ueno et al.   CURRENT MEDICINAL CHEMISTRY

New applications of disease genetics and pharmacogenetics to drug development

(2014) Allen D Roses et al.   CURRENT OPINION IN PHARMACOLOGY

Antioxidant Clinical Trials in Mild Cognitive Impairment and Alzheimer’s disease – Challenges and Perspectives

(2014) Maria Polidori et al.   CURRENT PHARMACEUTICAL DESIGN

Insulin Reverses the High-Fat Diet-Induced Increase in Brain A  and Improves Memory in an Animal Model of Alzheimer Disease

(2014) M. Vandal et al.   DIABETES

Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in β-amyloid induced Alzheimer׳s disease

(2014) Atish Prakash et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Fatty Acid-binding Protein 5 (FABP5) Regulates Cognitive Function Both by Decreasing Anandamide Levels and by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor β/δ (PPARβ/δ) in the Brain

(2014) Shuiliang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation-sleep interface in brain disease: TNF, insulin, orexin

(2014) Ian A Clark et al.   Journal of Neuroinflammation

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) protects against ceramide-induced cellular toxicity in rat brain astrocytes and neurons by activation of ceramide kinase

(2014) Stepan Aleshin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Diffusion tensor imaging of white matter degeneration in Alzheimer’s disease and mild cognitive impairment

(2014) I.K. Amlien et al.   NEUROSCIENCE

Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass

(2014) David J. Bonda et al.   Neuroscience Bulletin

Sulphonylurea Usage in Melioidosis Is Associated with Severe Disease and Suppressed Immune Response

(2014) Xiang Liu et al.   PLoS Neglected Tropical Diseases

Inflammasomes in neuroinflammation and changes in brain function: a focused review

(2014) Gaurav Singhal et al.   Frontiers in Neuroscience

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

Exome Sequence Reveals Mutations in CoA Synthase as a Cause of Neurodegeneration with Brain Iron Accumulation

(2013) Sabrina Dusi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice

(2013) Emma Barroso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

High-sugar diets, type 2 diabetes and Alzheimerʼs disease

(2013) Paula I. Moreira   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Incretin actions beyond the pancreas: lessons from knockout mice

(2013) Daisuke Yabe et al.   CURRENT OPINION IN PHARMACOLOGY

Identification and Characterization of GLP-1 Receptor-Expressing Cells Using a New Transgenic Mouse Model

(2013) P. Richards et al.   DIABETES

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

(2013) E. M. Moore et al.   DIABETES CARE

Mortality among veterans with type 2 diabetes initiating metformin, sulfonylurea or rosiglitazone monotherapy

(2013) S. Wheeler et al.   DIABETOLOGIA

Relationships Between Diabetes and Cognitive Impairment

(2013) Suzanne M. de la Monte   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Intranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the art

(2013) Suzanne M de la Monte   Expert Opinion on Drug Delivery

Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation

(2013) Thomas M. Schilling et al.   HUMAN BRAIN MAPPING

Magnetic resonance imaging: A biomarker for cognitive impairment in Parkinson's disease?

(2013) Gordon W. Duncan et al.   MOVEMENT DISORDERS

The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It's time for reconciliation

(2013) Eugenio Barone et al.   NEUROBIOLOGY OF DISEASE

Neurotoxic Saboteurs: Straws that Break the Hippo’s (Hippocampus) Back Drive Cognitive Impairment and Alzheimer’s Disease

(2013) Mak Adam Daulatzai   NEUROTOXICITY RESEARCH

Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease

(2013) Ines Moreno-Gonzalez et al.   Nature Communications

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Oxidative modification of lipoic acid by HNE in Alzheimer disease brain

(2013) Sarita S. Hardas et al.   Redox Biology

Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice

(2012) Lital Rachmany et al.   AGE

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice

(2012) Anantha Vijay R. Santhanam et al.   BRAIN RESEARCH

Metabolic syndrome, mild cognitive impairment and Alzheimer's disease—The emerging role of systemic low-grade inflammation and adiposity

(2012) Blazej Misiak et al.   BRAIN RESEARCH BULLETIN

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

(2012) Paula Agostinho et al.   CURRENT PHARMACEUTICAL DESIGN

Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans

(2012) K. Jauch-Chara et al.   DIABETES

Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment

(2012) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Leptin, Mild Cognitive Impairment, and Dementia Among Elderly Women

(2012) A. Zeki Al Hazzouri et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease

(2012) Adina N. Lazar et al.   Nanomedicine-Nanotechnology Biology and Medicine

Quintessential Risk Factors: Their Role in Promoting Cognitive Dysfunction and Alzheimer’s Disease

(2012) Mak Adam Daulatzai   NEUROCHEMICAL RESEARCH

A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort

(2012) Shashwath A. Meda et al.   NEUROIMAGE

The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-β Plaque and Glial Pathology in a Mouse Model of Alzheimer’s Disease

(2012) Caitriona M. Long-Smith et al.   NEUROMOLECULAR MEDICINE

The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer’s disease

(2012) A.M. Duffy et al.   NEUROSCIENCE

Oxidative Damage to RNA in Aging and Neurodegenerative Disorders

(2012) Akihiko Nunomura et al.   NEUROTOXICITY RESEARCH

Neuron-Specific Deletion of Peroxisome Proliferator-Activated Receptor Delta (PPARδ) in Mice Leads to Increased Susceptibility to Diet-Induced Obesity

(2012) Heidi E. Kocalis et al.   PLoS One

p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity

(2012) B. Baeza-Raja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcuminoids and resveratrol as anti-Alzheimer agents

(2012) Oliver B. Villaflores et al.   Taiwanese Journal of Obstetrics & Gynecology

A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer's Disease

(2012) Justin R. Piro et al.   Cell Reports

Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice

(2012) J. M. Fine et al.   EXPERIMENTAL BRAIN RESEARCH

Intranasal delivery of deferoxamine reduces spatial memory loss in APP/PS1 mice

(2012) Leah R. Hanson et al.   Drug Delivery and Translational Research

Diabetes and the elderly brain: sweet memories?

(2012) Katherine Samaras et al.   Therapeutic Advances in Endocrinology and Metabolism

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Vascular PPARδ Protects Against Stroke-Induced Brain Injury

(2011) Ke-Jie Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

(2011) Patrizia Mecocci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin resistance and Alzheimer's disease

(2011) Suzanne M. De La Monte   BMB Reports

Insulin resistance and pathological brain ageing

(2011) B. Cholerton et al.   DIABETIC MEDICINE

Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimerʼs Disease

(2011) Suzanne M. de la Monte   DRUGS

Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4

(2011) Scott E. Kanoski et al.   ENDOCRINOLOGY

GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake

(2011) Amber L. Alhadeff et al.   ENDOCRINOLOGY

A physiological role of glucagon-like peptide-1 receptors in the central nervous system of Suncus murinus (house musk shrew)

(2011) Sze Wa Chan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

HFE Gene Variants Affect Iron in the Brain

(2011) Wint Nandar et al.   JOURNAL OF NUTRITION

Vascular biology of metabolic syndrome

(2011) Daynene Vykoukal et al.   JOURNAL OF VASCULAR SURGERY

Association between HFE polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis of 22 studies including 4,365 cases and 8,652 controls

(2011) Min Lin et al.   MOLECULAR BIOLOGY REPORTS

Effects of hemochromatosis and transferrin gene mutations on iron dyshomeostasis, liver dysfunction and on the risk of Alzheimer's disease

(2011) Federica Giambattistelli et al.   NEUROBIOLOGY OF AGING

Bidirectional metabolic regulation of neurocognitive function

(2011) Alexis M. Stranahan et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder

(2011) Suzanne M de la Monte et al.   Molecular Brain

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons

(2010) Kathleen J. Griffioen et al.   CARDIOVASCULAR RESEARCH

REVIEW: Curcumin and Alzheimer's Disease

(2010) Tsuyoshi Hamaguchi et al.   CNS Neuroscience & Therapeutics

Is the Diminished Incretin Effect in Type 2 Diabetes Just an Epi-Phenomenon of Impaired  -Cell Function?

(2010) J. J. Meier et al.   DIABETES

Rosiglitazone and Cognitive Stability in Older Individuals With Type 2 Diabetes and Mild Cognitive Impairment

(2010) A. M. Abbatecola et al.   DIABETES CARE

Mitochondrial Dynamics in Alzheimerʼs Disease

(2010) David J. Bonda et al.   DRUGS & AGING

Intranasal insulin as a therapeutic option in the treatment of cognitive impairments

(2010) Christian Benedict et al.   EXPERIMENTAL GERONTOLOGY

Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease?

(2010) Nigel Irwin et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Peroxisome proliferator–activated receptor δ limits the expansion of pathogenic Th cells during central nervous system autoimmunity

(2010) Shannon E. Dunn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The link between iron, metabolic syndrome, and Alzheimer’s disease

(2010) Edna Grünblatt et al.   JOURNAL OF NEURAL TRANSMISSION

Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice

(2010) D. Piedrahita et al.   JOURNAL OF NEUROSCIENCE

Inflammatory Mediators and Insulin Resistance in Obesity: Role of Nuclear Receptor Signaling in Macrophages

(2010) Lucía Fuentes et al.   MEDIATORS OF INFLAMMATION

Vascular basis for brain degeneration: faltering controls and risk factors for dementia

(2010) Raj N Kalaria   NUTRITION REVIEWS

Review: Obesity and Alzheimer’s Disease: A Link Between Body Weight and Cognitive Function in Old Age

(2009) Ebrahim K. Naderali et al.   American Journal of Alzheimers Disease and Other Dementias

Promising Strategies for the Prevention of Dementia

(2009) Laura E. Middleton et al.   ARCHIVES OF NEUROLOGY

Role of the incretin pathway in the pathogenesis of type 2 diabetes mellitus

(2009) J. S. FREEMAN   CLEVELAND CLINIC JOURNAL OF MEDICINE

A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease

(2009) Sergey Kalinin et al.   Current Alzheimer Research

Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene

(2009) Ana G. Barbeito et al.   JOURNAL OF NEUROCHEMISTRY

Statins Reduce the Neurofibrillary Tangle Burden in a Mouse Model of Tauopathy

(2009) Moran Boimel et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment

(2009) Suzanne M de la Monte et al.   Molecular Neurodegeneration

Peroxisome Proliferator-Activated Receptor (PPAR)-  Positively Controls and PPAR  Negatively Controls Cyclooxygenase-2 Expression in Rat Brain Astrocytes through a Convergence on PPAR /  via Mutual Control of PPAR Expression Levels

(2009) S. Aleshin et al.   MOLECULAR PHARMACOLOGY

(Pre)diabetes, brain aging, and cognition

(2008) Jarbas S. Roriz-Filho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

(2008) Leah R Hanson et al.   BMC NEUROSCIENCE

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

PPAR Regulation of Inflammatory Signaling in CNS Diseases

(2008) John J. Bright et al.   PPAR Research