Exenatide Reverts the High-Fat-Diet-Induced Impairment of BDNF Signaling and Inflammatory Response in an Animal Model of Alzheimer’s Disease

Person-specific contribution of neuropathologies to cognitive loss in old age

(2018) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

PPARs in Neurodegenerative and Neuroinflammatory Pathways

(2018) E. Benedetti et al.   Current Alzheimer Research

A Novel Therapeutic Approach to Treat Alzheimer’s Disease by Neurotrophic Support During the Period of Synaptic Compensation

(2018) Narjes Baazaoui et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin regulates astrocyte gliotransmission and modulates behavior

(2018) Weikang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebrovascular and Alzheimer disease: fellow travelers or partners in crime?

(2018) Antonia Nucera et al.   JOURNAL OF NEUROCHEMISTRY

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Animal models of obesity and diabetes mellitus

(2018) Maximilian Kleinert et al.   Nature Reviews Endocrinology

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Exenatide exerts cognitive effects by modulating the BDNF-TrkB neurotrophic axis in adult mice

(2018) Manuela Bomba et al.   NEUROBIOLOGY OF AGING

Protective effects of the GLP-1 mimetic exendin-4 in Parkinson's disease

(2018) Dilan Athauda et al.   NEUROPHARMACOLOGY

The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice

(2018) Valerio Frazzini et al.   Scientific Reports

High-fat diet protects the blood-brain barrier in an Alzheimer's disease mouse model

(2018) Shirin Elhaik Goldman et al.   AGING CELL

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer’s disease

(2018) Gary P. Morris et al.   ACTA NEUROPATHOLOGICA

Alzheimer's Disease, time to turn the tide

(2018) Stefano L. Sensi   Aging-US

Towards Combinatorial Approaches for Preserving Cognitive Fitness in Aging

(2018) Anna-Katharine Brem et al.   TRENDS IN NEUROSCIENCES

Copper and Zinc Dysregulation in Alzheimer’s Disease

(2018) Stefano L. Sensi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Influence of High-Fat Diets Consumed During the Juvenile Period on Hippocampal Morphology and Function

(2018) Nuria Del Olmo et al.   Frontiers in Cellular Neuroscience

Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling

(2017) Wei Liu et al.   Nature Communications

The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action

(2016) Dilan Athauda et al.   DRUG DISCOVERY TODAY

Exenatide enhances cognitive performance and upregulates neurotrophic factor gene expression levels in diabetic mice

(2016) Esen Gumuslu et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

(2016) Molly Stanley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reduced neurotrophic factor level is the early event before the functional neuronal deficiency in high-fat diet induced obese mice

(2016) Huanhuan Wang et al.   METABOLIC BRAIN DISEASE

Investigation of brain-derived neurotrophic factor (BDNF) gene expression in hypothalamus of obese rats: Modulation by omega-3 fatty acids

(2016) Sahar M. Abdel-Maksoud et al.   NUTRITIONAL NEUROSCIENCE

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity

(2016) Bernat Baeza-Raja et al.   Cell Reports

An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus

(2016) Ahlke Heydemann   Journal of Diabetes Research

Localization of PPAR isotypes in the adult mouse and human brain

(2016) Anna Warden et al.   Scientific Reports

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents

(2015) Dmitry Petrov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Central Inhibition of IKKβ/NF-κB Signaling Attenuates High-Fat Diet–Induced Obesity and Glucose Intolerance

(2015) Jonas Benzler et al.   DIABETES

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology

(2015) Elisa Isopi et al.   NEUROBIOLOGY OF DISEASE

How does brain insulin resistance develop in Alzheimer's disease?

(2014) Fernanda G. De Felice et al.   Alzheimers & Dementia

Insulin Reverses the High-Fat Diet-Induced Increase in Brain A  and Improves Memory in an Animal Model of Alzheimer Disease

(2014) M. Vandal et al.   DIABETES

New drug treatments show neuroprotective effects in Alzheimer′s and Parkinson′s diseases

(2014) Christian Hölscher   Neural Regeneration Research

High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology

(2014) Elysse M. Knight et al.   NEUROBIOLOGY OF AGING

Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex

(2014) Nobuaki Ohtake et al.   REGULATORY PEPTIDES

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus

(2014) Jianmin Yang et al.   Cell Reports

Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα

(2014) Eugenia Morselli et al.   Cell Reports

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

(2013) Jonathan E. Campbell et al.   Cell Metabolism

A small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model

(2013) Juliet K. Knowles et al.   NEUROBIOLOGY OF AGING

The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

(2013) Tomi Rantamäki et al.   PLoS One

GLP-1R agonist therapy for diabetes

(2013) Susan L. Samson et al.   Current Opinion in Endocrinology Diabetes and Obesity

Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals

(2013) M Bomba et al.   Cell Death & Disease

A turning point for Alzheimer's disease?

(2012) Jack C. de la Torre   BIOFACTORS

Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders

(2012) Isidro Salcedo et al.   BRITISH JOURNAL OF PHARMACOLOGY

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD and wild-type mice

(2012) F Masciopinto et al.   Cell Death & Disease

Neurogenesis in Alzheimer’s disease

(2011) José J. Rodríguez et al.   JOURNAL OF ANATOMY

Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

(2011) A. Hamilton et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

(2010) David W. Porter et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity

(2010) Asja Wagener et al.   Lipids in Health and Disease

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

(2009) Suzanne Craft   ARCHIVES OF NEUROLOGY

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease

(2009) Talib Abbas et al.   BEHAVIOURAL BRAIN RESEARCH

ERK and cell death: ERK1/2 in neuronal death

(2009) Srinivasa Subramaniam et al.   FEBS Journal

Diet-induced obesity increases NF-κB signaling in reporter mice

(2009) Harald Carlsen et al.   Genes and Nutrition

Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet

(2009) Christy L. White et al.   NEUROBIOLOGY OF DISEASE

Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

(2009) Alison Hamilton et al.   NEUROREPORT

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease

(2008) José J. Rodríguez et al.   PLoS One