Insulin action and resistance in obesity and type 2 diabetes

Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice

(2017) Raymond E. Soccio et al.   JOURNAL OF CLINICAL INVESTIGATION

The Perilipins: Major Cytosolic Lipid Droplet–Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis

(2016) Alan R. Kimmel et al.   Annual Review of Nutrition

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

(2016) Paul M. Titchenell et al.   Cell Metabolism

Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice

(2016) Li Kang et al.   DIABETES

Toward Precision Medicine: TBC1D4 Disruption Is Common Among the Inuit and Leads to Underdiagnosis of Type 2 Diabetes

(2016) Despoina Manousaki et al.   DIABETES CARE

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia

(2016) Rachel J. Roth Flach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

(2016) Max C. Petersen et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning

(2016) Dianxin Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose tissue regulates insulin sensitivity: role of adipogenesis,de novolipogenesis and novel lipids

(2016) U. Smith et al.   JOURNAL OF INTERNAL MEDICINE

Diverse Activities of Histone Acylations Connect Metabolism to Chromatin Function

(2016) Arnob Dutta et al.   MOLECULAR CELL

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

(2016) Luca A Lotta et al.   NATURE GENETICS

Human 'brite/beige' adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice

(2016) So Yun Min et al.   NATURE MEDICINE

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Nuclear Mechanisms of Insulin Resistance

(2016) Sona Kang et al.   TRENDS IN CELL BIOLOGY

Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets

(2016) Nora Kory et al.   TRENDS IN CELL BIOLOGY

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

(2016) Yuefeng Tang et al.   Nature Communications

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

(2016) Eoin McDonnell et al.   Cell Reports

Insulin, insulin receptors, and cancer

(2016) R. Vigneri et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lep ob/ob mice

(2016) Anna M. D'souza et al.   Molecular Metabolism

The Roles of mTOR Complexes in Lipid Metabolism

(2015) Alexandre Caron et al.   Annual Review of Nutrition

One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice

(2015) T. M. Zaved Waise et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo

(2015) Raymond E. Soccio et al.   CELL

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes

(2015) Christopher J. Nolan et al.   DIABETES

Deciphering Metabolic Messages From the Gut Drives Therapeutic Innovation: The 2014 Banting Lecture

(2015) Daniel J. Drucker   DIABETES

In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice

(2015) Sabina Paglialunga et al.   DIABETOLOGIA

Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity

(2015) Nicole M. Templeman et al.   DIABETOLOGIA

The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo

(2015) Shlomit Koren et al.   DIABETOLOGIA

FAT FLUX: enzymes, regulators, and pathophysiology of intracellular lipolysis

(2015) R. Zechner   EMBO Molecular Medicine

Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice

(2015) Gabriele Schoiswohl et al.   ENDOCRINOLOGY

Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-Cells

(2015) Karel A. Erion et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin α1-null Mice Exhibit Improved Fatty Liver When Fed a High Fat Diet Despite Severe Hepatic Insulin Resistance

(2015) Ashley S. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Insulin Resistance in Adipocytes

(2015) Shi-Xiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenotypic Characterization of Insulin-Resistant and Insulin-Sensitive Obesity

(2015) D. L. Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin

(2015) Lisa M. DiPilato et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of metabolism by the innate immune system

(2015) Denise E. Lackey et al.   Nature Reviews Endocrinology

Hyperinsulinemia in individuals with obesity: Role of insulin clearance

(2015) Mee Kyoung Kim et al.   Obesity

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men

(2015) Guenther Boden et al.   Science Translational Medicine

The extracellular matrix and insulin resistance

(2015) Ashley S. Williams et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2015) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice

(2015) Linkang Zhou et al.   Nature Communications

Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements

(2015) Thomas S. Morley et al.   Nature Communications

A major role of insulin in promoting obesity-associated adipose tissue inflammation

(2015) David J. Pedersen et al.   Molecular Metabolism

De novo lipogenesis in metabolic homeostasis: More friend than foe?

(2015) Giovanni Solinas et al.   Molecular Metabolism

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

Adipsin Is an Adipokine that Improves β Cell Function in Diabetes

(2014) James C. Lo et al.   CELL

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

The Browning of White Adipose Tissue: Some Burning Issues

(2014) Jan Nedergaard et al.   Cell Metabolism

Inhibited Insulin Signaling in Mouse Hepatocytes Is Associated with Increased Phosphatidic Acid but Not Diacylglycerol

(2014) Chongben Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Adipose Tissue Expandability in Response to High Fat Diet by the Insulin-like Growth Factor-binding Protein-4

(2014) Olga Gealekman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of Adipose Tissue and Liver Fibrosis With Tissue Stiffness in Morbid Obesity: Links With Diabetes and BMI Loss After Gastric Bypass

(2014) Meriem Abdennour et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

PPARγ and the global map of adipogenesis and beyond

(2014) Martina I. Lefterova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia

(2014) Benjamin Barzel et al.   Frontiers in Physiology

Adipose tissue angiogenesis: Impact on obesity and type-2 diabetes

(2013) Silvia Corvera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

(2013) N. Turner et al.   DIABETOLOGIA

Insulin signalling mechanisms for triacylglycerol storage

(2013) M. P. Czech et al.   DIABETOLOGIA

Start of insulin therapy in patients with type 2 diabetes mellitus promotes the influx of macrophages into subcutaneous adipose tissue

(2013) H. J. Jansen et al.   DIABETOLOGIA

Balancing the fat: lipid droplets and human disease

(2013) Natalie Krahmer et al.   EMBO Molecular Medicine

Functional Cardiac Lipolysis in Mice Critically Depends on Comparative Gene Identification-58

(2013) Kathrin A. Zierler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

(2013) Nigel Turner et al.   JOURNAL OF ENDOCRINOLOGY

Effects of a single bout of aerobic exercise on short-term low-carbohydrate/high-fat intake-induced postprandial glucose metabolism during an oral glucose tolerance test

(2013) Shigeharu Numao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

DNMT1 Is Regulated by ATP-Citrate Lyase and Maintains Methylation Patterns during Adipocyte Differentiation

(2013) T. Londono Gentile et al.   MOLECULAR AND CELLULAR BIOLOGY

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Calcium Signaling through CaMKII Regulates Hepatic Glucose Production in Fasting and Obesity

(2012) Lale Ozcan et al.   Cell Metabolism

Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-Induced Obesity

(2012) Irfan J. Lodhi et al.   Cell Metabolism

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Diabetes: Have We Got It All Wrong?: Insulin hypersecretion and food additives: cause of obesity and diabetes?

(2012) B. E. Corkey   DIABETES CARE

Diabetes: Have We Got It All Wrong?: Hyperinsulinism as the culprit: surgery provides the evidence

(2012) W. J. Pories et al.   DIABETES CARE

The role of glycogen synthase in the development of hyperglycemia in type 2 diabetes - ‘To store or not to store glucose, that's the question’

(2012) Henning Beck-Nielsen   DIABETES-METABOLISM RESEARCH AND REVIEWS

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Short Term Voluntary Overfeeding Disrupts Brain Insulin Control of Adipose Tissue Lipolysis

(2012) Thomas Scherer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short Term High Fat Diet Challenge Promotes Alternative Macrophage Polarization in Adipose Tissue via Natural Killer T Cells and Interleukin-4

(2012) Yewei Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

Serum Acylated Ghrelin Concentrations in Response to Short-Term Overfeeding in Normal Weight, Overweight, and Obese Men

(2012) Danny Wadden et al.   PLoS One

High Insulin and Leptin Increase Resistin and Inflammatory Cytokine Production from Human Mononuclear Cells

(2012) Panayoula C. Tsiotra et al.   Biomed Research International

Serum peptide YY in response to short-term overfeeding in young men

(2011) Farrell Cahill et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature

(2011) Eugene J. Barrett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice

(2011) Alexander S. Banks et al.   Cell Metabolism

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin  2 1 in Mice

(2011) L. Kang et al.   DIABETES

Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

(2011) B. E. Corkey   DIABETES

Mechanistic insights into insulin resistance in the genetic era

(2011) V. E. R. Parker et al.   DIABETIC MEDICINE

Epigenetic codes of PPARγ in metabolic disease

(2011) Shigeki Sugii et al.   FEBS LETTERS

Effects of brief perturbations in energy balance on indices of glucose homeostasis in healthy lean men

(2011) M Lagerpusch et al.   INTERNATIONAL JOURNAL OF OBESITY

Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes

(2011) Shi-Xiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perilipin Deficiency and Autosomal Dominant Partial Lipodystrophy

(2011) Sheetal Gandotra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Perinephric and Epididymal Fat Affect Hepatic Metabolism in Rats

(2011) Shani Ben-Shlomo et al.   Obesity

Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor

(2011) E. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin-sensitive obesity

(2010) Nora Klöting et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes

(2010) Mary-Elizabeth Patti et al.   ENDOCRINE REVIEWS

Insulin Regulates Adipocyte Lipolysis via an Akt-Independent Signaling Pathway

(2010) S. M. Choi et al.   MOLECULAR AND CELLULAR BIOLOGY

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance

(2010) Guadalupe Sabio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Effect of hyperinsulinemia and very-low-calorie diet on interstitial cytokine levels in subcutaneous adipose tissue of obese women

(2009) Michaela Siklova-Vitkova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

(2009) Karla F. Leavens et al.   Cell Metabolism

Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation inCIDEC

(2009) Oscar Rubio-Cabezas et al.   EMBO Molecular Medicine

Adipose Triglyceride Lipase Deficiency Causes Tissue-specific Changes in Insulin Signaling

(2009) Petra C. Kienesberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men

(2009) Charlotte Brøns et al.   JOURNAL OF PHYSIOLOGY-LONDON

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Insulin regulation of MCP-1 in human adipose tissue of obese and lean women

(2008) Jukka Westerbacka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

(2008) Sudha B. Biddinger et al.   Cell Metabolism

IRS1-Independent Defects Define Major Nodes of Insulin Resistance

(2008) Kyle L. Hoehn et al.   Cell Metabolism

Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism

(2008) Thien T. Tran et al.   Cell Metabolism

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Insulin Resistance and Hyperinsulinemia: You can't have one without the other

(2008) S. H. Kim et al.   DIABETES CARE

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of FoxO in the regulation of metabolism

(2008) D N Gross et al.   ONCOGENE

Cidea is associated with lipid droplets and insulin sensitivity in humans

(2008) V. Puri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE