Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?
出版年份 2020 全文链接
标题
Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?
作者
关键词
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出版物
CLINICAL SCIENCE
Volume 134, Issue 5, Pages 547-570
出版商
Portland Press Ltd.
发表日期
2020-03-13
DOI
10.1042/cs20191313
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Relation of the degree of obesity in childhood to adipose tissue insulin resistance
- (2019) Emilia Hagman et al. ACTA DIABETOLOGICA
- Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells
- (2019) Stefanie Bader et al. PSYCHONEUROENDOCRINOLOGY
- Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice
- (2019) Susana Castelo Branco Ramos Nakandakari et al. BRAIN BEHAVIOR AND IMMUNITY
- In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice
- (2019) Jenny Sandström et al. ARCHIVES OF TOXICOLOGY
- Priming Microglia for Innate Immune Memory in the Brain
- (2019) Jonas J. Neher et al. TRENDS IN IMMUNOLOGY
- Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer’s disease by remodeling peri-plaque astrocyte structure
- (2019) Alex J. Smith et al. Acta Neuropathologica Communications
- Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer’s disease by restoring microglial function via a PPAR-γ-dependent mechanism
- (2019) Elisa Medrano-Jiménez et al. Journal of Neuroinflammation
- 11β-HSD1 Inhibition Rescues SAMP8 Cognitive Impairment Induced by Metabolic Stress
- (2019) Dolors Puigoriol-Illamola et al. MOLECULAR NEUROBIOLOGY
- Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease
- (2019) Michael Ewers et al. Science Translational Medicine
- The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer’s Dementia
- (2019) Jaume Folch et al. Frontiers in Aging Neuroscience
- Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species
- (2019) Xu-Qiao Chen et al. Frontiers in Neuroscience
- Exenatide Reverts the High-Fat-Diet-Induced Impairment of BDNF Signaling and Inflammatory Response in an Animal Model of Alzheimer’s Disease
- (2019) Manuela Bomba et al. JOURNAL OF ALZHEIMERS DISEASE
- NLRP3 inflammasome activation drives tau pathology
- (2019) Christina Ising et al. NATURE
- Adaptive immunity: an emerging player in the progression of NAFLD
- (2019) Salvatore Sutti et al. Nature Reviews Gastroenterology & Hepatology
- How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases
- (2019) Wolfgang Kopp Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment
- (2018) Igor Pomytkin et al. CNS Neuroscience & Therapeutics
- TSPO–PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington’s disease: preclinical evidence with the p75NTR ligand LM11A-31
- (2018) Danielle A Simmons et al. HUMAN MOLECULAR GENETICS
- Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models
- (2018) Slava Rom et al. MOLECULAR NEUROBIOLOGY
- Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
- (2018) Steven E. Arnold et al. Nature Reviews Neurology
- Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
- (2018) Melanie D. Sweeney et al. Nature Reviews Neurology
- Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics
- (2018) Mark A. Petersen et al. NATURE REVIEWS NEUROSCIENCE
- TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
- (2018) Yingjun Zhao et al. NEURON
- Normal aging induces A1-like astrocyte reactivity
- (2018) Laura E. Clarke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment
- (2018) Dunja Knezevic et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer's disease and the possible mechanisms in CHO-APP/PS1 cells and SAMP8 mice
- (2018) Hongxia Che et al. Food & Function
- TLR4-NF-κB Signal Involved in Depressive-Like Behaviors and Cytokine Expression of Frontal Cortex and Hippocampus in Stressed C57BL/6 and ob/ob Mice
- (2018) Yihe Wang et al. NEURAL PLASTICITY
- Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits
- (2018) Shreyasi Chatterjee et al. Frontiers in Neuroscience
- Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
- (2018) Cyril Laurent et al. Biomedical Journal
- Adipose tissue inflammation and metabolic syndrome. The proactive role of probiotics
- (2018) Sebastian Torres et al. EUROPEAN JOURNAL OF NUTRITION
- Properties and functions of adipose tissue macrophages in obesity
- (2018) Lucia Russo et al. IMMUNOLOGY
- Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation
- (2018) Yi-Heng Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease
- (2018) Estella A. Newcombe et al. Journal of Neuroinflammation
- Insulin transport across the blood-brain barrier can occur independently of the insulin receptor
- (2018) Elizabeth M. Rhea et al. JOURNAL OF PHYSIOLOGY-LONDON
- Distinguishing normal brain aging from the development of Alzheimer's disease: inflammation, insulin signaling and cognition
- (2018) Paul Denver et al. Neural Regeneration Research
- Soluble TREM2 changes during the clinical course of Alzheimer’s disease: A meta-analysis
- (2018) Dan Liu et al. NEUROSCIENCE LETTERS
- What have we learned recently from transgenic mouse models about neurodegeneration? The most promising discoveries of this millennium
- (2018) Grzegorz Kreiner Pharmacological Reports
- Chia Seed Does Not Improve Cognitive Impairment in SAMP8 Mice Fed with High Fat Diet
- (2018) Yehua Rui et al. Nutrients
- Elucidating the Interactive Roles of Glia in Alzheimer's Disease Using Established and Newly Developed Experimental Models
- (2018) Heejung Chun et al. Frontiers in Neurology
- Adipose Tissue Insulin Resistance in Youth on the Spectrum From Normal Weight to Obese and From Normal Glucose Tolerance to Impaired Glucose Tolerance to Type 2 Diabetes
- (2018) Joon Young Kim et al. DIABETES CARE
- Obesity and dysregulated central and peripheral macrophage-neuron cross-talk
- (2018) Sigalit Boura-Halfon et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Type 2 Diabetes Mellitus and Alzheimer’s Disease: Role of Insulin Signalling and Therapeutic Implications
- (2018) Andrea Tumminia et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity
- (2018) V. Alexandra Moser et al. Journal of Neuroinflammation
- Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology
- (2018) Martina Holubová et al. NEUROPHARMACOLOGY
- Tau monomer encodes strains
- (2018) Apurwa M Sharma et al. eLife
- Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease
- (2018) Mikael Marttinen et al. Frontiers in Neuroscience
- Microglia in Alzheimer's Disease: Risk Factors and Inflammation
- (2018) Atsuko Katsumoto et al. Frontiers in Neurology
- The impact of anorexigenic peptides in experimental models of Alzheimer’s disease pathology
- (2018) Lenka Maletínská et al. JOURNAL OF ENDOCRINOLOGY
- A state of delirium: Deciphering the effect of inflammation on tau pathology in Alzheimer's disease
- (2017) Matthew Barron et al. EXPERIMENTAL GERONTOLOGY
- An Updated View of Translocator Protein (TSPO)
- (2017) Nunzio Denora et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tau Oligomers in Sera of Patients with Alzheimer’s Disease and Aged Controls
- (2017) Michala Kolarova et al. JOURNAL OF ALZHEIMERS DISEASE
- Astrocytic tight junctions control inflammatory CNS lesion pathogenesis
- (2017) Sam Horng et al. JOURNAL OF CLINICAL INVESTIGATION
- Inflammatory mechanisms linking obesity and metabolic disease
- (2017) Alan R. Saltiel et al. JOURNAL OF CLINICAL INVESTIGATION
- Tau deletion promotes brain insulin resistance
- (2017) Elodie Marciniak et al. JOURNAL OF EXPERIMENTAL MEDICINE
- M1 Means Kill; M2 Means Heal
- (2017) Klaus Ley JOURNAL OF IMMUNOLOGY
- The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications
- (2017) Anna Alisi et al. MEDIATORS OF INFLAMMATION
- Practical considerations for choosing a mouse model of Alzheimer’s disease
- (2017) Joanna L. Jankowsky et al. Molecular Neurodegeneration
- ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
- (2017) Yang Shi et al. NATURE
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- Insulin action and resistance in obesity and type 2 diabetes
- (2017) Michael P Czech NATURE MEDICINE
- Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers
- (2017) Kaitlin B. Casaletto et al. NEUROLOGY
- Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage
- (2017) Scott S. Shafiei et al. Frontiers in Aging Neuroscience
- Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome
- (2017) Gema Frühbeck et al. Scientific Reports
- Widespread tau seeding activity at early Braak stages
- (2016) Jennifer L. Furman et al. ACTA NEUROPATHOLOGICA
- Alzheimer’s disease: experimental models and reality
- (2016) Eleanor Drummond et al. ACTA NEUROPATHOLOGICA
- Neuroinflammation in Alzheimer's disease: Current evidence and future directions
- (2016) Valeria Calsolaro et al. Alzheimers & Dementia
- Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels
- (2016) Henry H. Ruiz et al. Alzheimers & Dementia
- Glial influences on BBB functions and molecular players in immune cell trafficking
- (2016) Marc-André Lécuyer et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Adiponectin, TNF-α and inflammatory cytokines and risk of type 2 diabetes: A systematic review and meta-analysis
- (2016) Chenxiao Liu et al. CYTOKINE
- Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer’s Disease
- (2016) Suzanne M. de la Monte DRUGS
- Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases
- (2016) Ashley N. Nilson et al. JOURNAL OF ALZHEIMERS DISEASE
- Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?
- (2016) Molly Stanley et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model
- (2016) Do-Geun Kim et al. Journal of Neuroinflammation
- The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice
- (2016) Molly Stanley et al. JOURNAL OF NEUROSCIENCE
- APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease
- (2016) G. D. Manocha et al. JOURNAL OF NEUROSCIENCE
- CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis
- (2016) Bob Olsson et al. LANCET NEUROLOGY
- Pericytes of the neurovascular unit: key functions and signaling pathways
- (2016) Melanie D Sweeney et al. NATURE NEUROSCIENCE
- Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice
- (2016) Noura B. El Khoury et al. NEUROBIOLOGY OF DISEASE
- The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice
- (2016) Carola I. F. Janssen et al. PLoS One
- Early changes in CSF sTREM2 in dominantly inherited Alzheimers disease occur after amyloid deposition and neuronal injury
- (2016) M. Suarez-Calvet et al. Science Translational Medicine
- Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease
- (2016) Deepak Kumar Vijaya Kumar et al. Science Translational Medicine
- Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease
- (2015) Hlin Kvartsberg et al. Alzheimers & Dementia
- Macrophages: Development and Tissue Specialization
- (2015) Chen Varol et al. Annual Review of Immunology
- Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system
- (2015) Elly M Hol et al. CURRENT OPINION IN CELL BIOLOGY
- Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPKSer-485Phosphorylation
- (2015) Bhumsoo Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neuroinflammation in Alzheimer's disease
- (2015) Michael T Heneka et al. LANCET NEUROLOGY
- Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
- (2015) Tamás Rőszer MEDIATORS OF INFLAMMATION
- Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
- (2015) Elena Zenaro et al. NATURE MEDICINE
- Depletion of microglia and inhibition of exosome synthesis halt tau propagation
- (2015) Hirohide Asai et al. NATURE NEUROSCIENCE
- Immune attack: the role of inflammation in Alzheimer disease
- (2015) Frank L. Heppner et al. NATURE REVIEWS NEUROSCIENCE
- Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice
- (2015) Chi-Wen Yeh et al. NEUROBIOLOGY OF AGING
- The Glymphatic System: A Beginner’s Guide
- (2015) Nadia Aalling Jessen et al. NEUROCHEMICAL RESEARCH
- Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
- (2015) Axel Montagne et al. NEURON
- Models and mechanisms for hippocampal dysfunction in obesity and diabetes
- (2015) A.M. Stranahan NEUROSCIENCE
- Macrophage recruitment in obese adipose tissue
- (2015) Y. Bai et al. Obesity Reviews
- The Blood–Brain Barrier
- (2015) Richard Daneman et al. Cold Spring Harbor Perspectives in Biology
- Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation
- (2015) Jae Kyu Ryu et al. Nature Communications
- Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer’s disease patients and healthy controls
- (2015) Hlin Kvartsberg et al. Alzheimers Research & Therapy
- Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity
- (2015) Nathalie Castanon et al. Frontiers in Neuroscience
- The Role of Ion Channels in Microglial Activation and Proliferation – A Complex Interplay between Ligand-Gated Ion Channels, K+ Channels, and Intracellular Ca2+
- (2015) Martin James Stebbing et al. Frontiers in Immunology
- Autoregulated paracellular clearance of amyloid- across the blood-brain barrier
- (2015) J. Keaney et al. Science Advances
- The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier?
- (2015) Tina Sartorius et al. PLoS One
- Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies
- (2014) Mark Yarchoan et al. ACTA NEUROPATHOLOGICA
- Impairment of paravascular clearance pathways in the aging brain
- (2014) Benjamin T. Kress et al. ANNALS OF NEUROLOGY
- Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?
- (2014) Pooja Naik et al. BMC NEUROSCIENCE
- Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease
- (2014) F. G. De Felice et al. DIABETES
- Insulin Reverses the High-Fat Diet-Induced Increase in Brain A and Improves Memory in an Animal Model of Alzheimer Disease
- (2014) M. Vandal et al. DIABETES
- Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review
- (2014) Suzanne M. de la Monte EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Decoding insulin resistance and metabolic syndrome for promising therapeutic intervention
- (2014) Shaodong Guo JOURNAL OF ENDOCRINOLOGY
- Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia
- (2014) Yali Wang et al. JOURNAL OF NEUROCHEMISTRY
- Adipokines: a link between obesity and dementia?
- (2014) Amanda J Kiliaan et al. LANCET NEUROLOGY
- Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models
- (2014) Lindsay A. Hohsfield et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Microglial priming in neurodegenerative disease
- (2014) V. Hugh Perry et al. Nature Reviews Neurology
- Insulin resistance in Alzheimer's disease
- (2014) Kelly T. Dineley et al. NEUROBIOLOGY OF DISEASE
- Proteopathic tau seeding predicts tauopathy in vivo
- (2014) B. B. Holmes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteomic characterization of human proinflammatory M1 and anti-inflammatory M2 macrophages and their response toCandida albicans
- (2014) Jose Antonio Reales-Calderón et al. PROTEOMICS
- Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice
- (2014) Juan Jose Ramos-Rodriguez et al. PSYCHONEUROENDOCRINOLOGY
- High Activities of BACE1 in Brains with Mild Cognitive Impairment
- (2013) Xin Cheng et al. AMERICAN JOURNAL OF PATHOLOGY
- Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
- (2013) Christopher N. Parkhurst et al. CELL
- Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1 Antibody, in Patients With Type 2 Diabetes
- (2013) J. Sloan-Lancaster et al. DIABETES CARE
- Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation
- (2013) Dora Lippai et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Microglial Phenotype and Adaptation
- (2013) B. J. L. Eggen et al. Journal of Neuroimmune Pharmacology
- Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele
- (2013) Hiramani Dhungana et al. Journal of Neuroinflammation
- Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease
- (2013) Alberto Serrano-Pozo et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- The NLRP3 Inflammasome in Alzheimer’s Disease
- (2013) Meng-Shan Tan et al. MOLECULAR NEUROBIOLOGY
- CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
- (2013) Elizabeth M Bradshaw et al. NATURE NEUROSCIENCE
- Prefibrillar Tau Oligomers in Mild Cognitive Impairment and Alzheimer's Disease
- (2013) Elliott J. Mufson et al. Neurodegenerative Diseases
- Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
- (2013) Ana Griciuc et al. NEURON
- Macrophage Polarisation: an Immunohistochemical Approach for Identifying M1 and M2 Macrophages
- (2013) Mário Henrique M. Barros et al. PLoS One
- Expression of Tau40 Induces Activation of Cultured Rat Microglial Cells
- (2013) Lu Wang et al. PLoS One
- Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration
- (2013) V. Hugh Perry et al. Seminars in Immunopathology
- A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer's brain tissues
- (2013) Jun-ichi Satoh et al. Alzheimers Research & Therapy
- Proteolytic Degradation of Amyloid -Protein
- (2013) T. Saido et al. Cold Spring Harbor Perspectives in Medicine
- Tau protein kinases: Involvement in Alzheimer's disease
- (2012) Ludovic Martin et al. AGEING RESEARCH REVIEWS
- Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease
- (2012) Jesse D. Sengillo et al. BRAIN PATHOLOGY
- Metabolic syndrome, mild cognitive impairment and Alzheimer's disease—The emerging role of systemic low-grade inflammation and adiposity
- (2012) Blazej Misiak et al. BRAIN RESEARCH BULLETIN
- The SAMP8 Mouse: A Model to Develop Therapeutic Interventions for Alzheimers Disease
- (2012) John E. Morley et al. CURRENT PHARMACEUTICAL DESIGN
- Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis
- (2012) Luis Varela et al. EMBO REPORTS
- An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
- (2012) Theresa R. Bomfim et al. JOURNAL OF CLINICAL INVESTIGATION
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
- (2012) Konrad Talbot et al. JOURNAL OF CLINICAL INVESTIGATION
- Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit
- (2012) Jérôme Badaut et al. Journal of Neuroinflammation
- A 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling
- (2012) S.-Y. Kook et al. JOURNAL OF NEUROSCIENCE
- Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease
- (2012) J. L. Furman et al. JOURNAL OF NEUROSCIENCE
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
- (2012) Konstantin Stark et al. NATURE IMMUNOLOGY
- Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
- (2012) Emmanuel L Gautier et al. NATURE IMMUNOLOGY
- Neuroinflammation and Blood-Brain Barrier Changes in Capillary Amyloid Angiopathy
- (2012) Anna Carrano et al. Neurodegenerative Diseases
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis
- (2012) Deepak Kumar Kaushik et al. PLoS One
- A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid
- (2012) J. J. Iliff et al. Science Translational Medicine
- Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
- (2012) Dimitrios Davalos et al. Nature Communications
- Multiple cellular and molecular mechanisms Are involved in human Aβ clearance by transplanted adult astrocytes
- (2011) Rea Pihlaja et al. GLIA
- A Common Pathogenic Mechanism Linking Type-2 Diabetes and Alzheimer's Disease: Evidence from Animal Models
- (2011) Sun Ah Park Journal of Clinical Neurology
- Critical Role of Astroglial Apolipoprotein E and Liver X Receptor- Expression for Microglial A Phagocytosis
- (2011) D. Terwel et al. JOURNAL OF NEUROSCIENCE
- Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
- (2011) Berislav V. Zlokovic NATURE REVIEWS NEUROSCIENCE
- Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation
- (2011) Markus P. Kummer et al. NEURON
- Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice
- (2011) Mian Bi et al. PLoS One
- Mechanisms Underlying Inflammation in Neurodegeneration
- (2010) Christopher K. Glass et al. CELL
- Macrophage Colony-Stimulating Factor (M-CSF) in Plasma and CSF of Patients with Mild Cognitive Impairment and Alzheimers Disease
- (2010) C. Laske et al. Current Alzheimer Research
- Effects of the Dietary Approaches to Stop Hypertension Diet, Exercise, and Caloric Restriction on Neurocognition in Overweight Adults With High Blood Pressure
- (2010) Patrick J. Smith et al. HYPERTENSION
- Nuclear Tau, a Key Player in Neuronal DNA Protection
- (2010) Audrey Sultan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pericytes are required for blood–brain barrier integrity during embryogenesis
- (2010) Richard Daneman et al. NATURE
- The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
- (2010) Takashi Satoh et al. NATURE IMMUNOLOGY
- Reactive astrocytes give neurons less support: implications for Alzheimer's disease
- (2010) Megan L. Steele et al. NEUROBIOLOGY OF AGING
- Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease
- (2010) Marta Cortes-Canteli et al. NEURON
- The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide
- (2010) Stephanie J. Soscia et al. PLoS One
- Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A deposition in an Alzheimer mouse model with diabetes
- (2010) S. Takeda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Thrombin Mediates Severe Neurovascular Injury During Ischemia
- (2010) Bo Chen et al. STROKE
- Astrocytes: biology and pathology
- (2009) Michael V. Sofroniew et al. ACTA NEUROPATHOLOGICA
- Interferon-γ Differentially Affects Alzheimer’s Disease Pathologies and Induces Neurogenesis in Triple Transgenic-AD Mice
- (2009) Michael A. Mastrangelo et al. AMERICAN JOURNAL OF PATHOLOGY
- Pathophysiology of type 2 diabetes mellitus in youth: the evolving chameleon
- (2009) Hala Tfayli et al. Arquivos Brasileiros de Endocrinologia e Metabologia
- Inflammation in transgenic mouse models of neurodegenerative disorders
- (2009) Claudia Schwab et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders
- (2009) Louis A. Profenno et al. BIOLOGICAL PSYCHIATRY
- APP transgenic modeling of Alzheimer’s disease: mechanisms of neurodegeneration and aberrant neurogenesis
- (2009) Leslie Crews et al. Brain Structure & Function
- Lipopolysaccharide-Activated Microglia Induce Dysfunction of the Blood–Brain Barrier in Rat Microvascular Endothelial Cells Co-Cultured with Microglia
- (2009) Noriko Sumi et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Interferon γ Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway
- (2009) Fiona C. McGillicuddy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases
- (2009) Yang Yu et al. JOURNAL OF NEUROCHEMISTRY
- A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
- (2009) Christine L. Hsieh et al. JOURNAL OF NEUROCHEMISTRY
- Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals
- (2009) H. Wake et al. JOURNAL OF NEUROSCIENCE
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- (2006) E. Hellström-Lindahl et al. NEUROBIOLOGY OF AGING
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