Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial

(2017) Suzanne Craft et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain Insulin-Like Growth Factor and Neurotrophin Resistance in Parkinson's Disease and Dementia with Lewy Bodies: Potential Role of Manganese Neurotoxicity

(2017) Ming Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology

(2016) Erin L. Abner et al.   Alzheimers & Dementia

Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels

(2016) Henry H. Ruiz et al.   Alzheimers & Dementia

Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction

(2016) Ying Cui et al.   Brain Imaging and Behavior

Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?

(2016) Mariko Taga et al.   BRAIN PATHOLOGY

Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease

(2016) Dalia El-Lebedy et al.   Cardiovascular Diabetology

Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture

(2016) George L. King et al.   DIABETES

Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation

(2016) Candace M. Reno et al.   DIABETES

Mechanisms of β-cell functional adaptation to changes in workload

(2016) M. Wortham et al.   DIABETES OBESITY & METABOLISM

Genes, Genetics, and Environment in Type 2 Diabetes: Implication in Personalized Medicine

(2016) Nabodita Kaul et al.   DNA AND CELL BIOLOGY

Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

(2016) José A. Luchsinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer’s Disease

(2016) Isaura V.A. Martins et al.   JOURNAL OF ALZHEIMERS DISEASE

White Matter Microstructure and Cognitive Function in Young Women With Polycystic Ovary Syndrome

(2016) D. Aled Rees et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes

(2016) Fang-Chi Hsu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

(2016) Molly Stanley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The neuronal insulin receptor in its environment

(2016) Matthias Gralle   JOURNAL OF NEUROCHEMISTRY

HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation

(2016) Manmeet K. Mamik et al.   Journal of Neuroimmune Pharmacology

Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory

(2016) Jiah Pearson-Leary et al.   JOURNAL OF NEUROSCIENCE

Chronic type 2 diabetes reduces the integrity of the blood-brain barrier by reducing tight junction proteins in the hippocampus

(2016) Dae Young YOO et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Impaired fasting glucose is associated with increased regional cerebral amyloid

(2016) Jill K. Morris et al.   NEUROBIOLOGY OF AGING

Glucose levels during life and neuropathologic findings at autopsy among people never treated for diabetes

(2016) Paul K. Crane et al.   NEUROBIOLOGY OF AGING

The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity

(2016) Adam H. Dyer et al.   NEUROSCIENCE

Is type 2 diabetes related to leukoaraiosis? an updated review

(2015) A. Del Bene et al.   ACTA NEUROLOGICA SCANDINAVICA

Insulin resistance predicts brain amyloid deposition in late middle-aged adults

(2015) Auriel A. Willette et al.   Alzheimers & Dementia

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

(2015) Heather M. Snyder et al.   Alzheimers & Dementia

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Insulin Modulates In Vitro Secretion of Cytokines and Cytotoxins by Human Glial Cells

(2015) Lindsay Spielman et al.   Current Alzheimer Research

Insulin Resistance Predicts Medial Temporal Hypermetabolism in Mild Cognitive Impairment Conversion to Alzheimer Disease

(2015) Auriel A. Willette et al.   DIABETES

Recent advances in understanding the genetic architecture of type 2 diabetes

(2015) Karen L. Mohlke et al.   HUMAN MOLECULAR GENETICS

Central Insulin Administration Improves Odor-Cued Reactivation of Spatial Memory in Young Men

(2015) Yvonne F. Brünner et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

Identification of diabetes-related dementia: Longitudinal perfusion SPECT and amyloid PET studies

(2015) Raita Fukasawa et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Blood Pressure is Associated With Cerebral Blood Flow Alterations in Patients With T2DM as Revealed by Perfusion Functional MRI

(2015) Wenqing Xia et al.   MEDICINE

Glucose indices are associated with cognitive and structural brain measures in young adults

(2015) G. Weinstein et al.   NEUROLOGY

Type 2 diabetes mellitus and biomarkers of neurodegeneration

(2015) Chris Moran et al.   NEUROLOGY

High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity

(2015) Zhigang Liu et al.   PLoS One

Glucose improves object-location binding in visual-spatial working memory

(2015) Brian Stollery et al.   PSYCHOPHARMACOLOGY

Disrupted resting-state attentional networks in T2DM patients

(2015) Wenqing Xia et al.   Scientific Reports

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

(2015) Claire J. Garwood et al.   Molecular Brain

Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test

(2015) Feven Berhane et al.   Journal of Diabetes Research

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease

(2015) Auriel A. Willette et al.   JAMA Neurology

The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier?

(2015) Tina Sartorius et al.   PLoS One

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies

(2014) Mark Yarchoan et al.   ACTA NEUROPATHOLOGICA

Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism

(2014) Andrew C. Shin et al.   Cell Metabolism

Intranasal Insulin Enhanced Resting-State Functional Connectivity of Hippocampal Regions in Type 2 Diabetes

(2014) Hui Zhang et al.   DIABETES

Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease

(2014) M. Yarchoan et al.   DIABETES

Brain imaging in type 2 diabetes

(2014) Manon Brundel et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Neuropathology of type 2 diabetes: a short review on insulin-related mechanisms

(2014) Elizabeth Guerrero-Berroa et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Neural substrates of verbal memory impairments in adults with type 2 diabetes mellitus

(2014) Po Lai Yau et al.   JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

Diet-induced obesity accelerates the onset of terminal phenotypes in α-synuclein transgenic mice

(2014) Carola Rotermund et al.   JOURNAL OF NEUROCHEMISTRY

Diabetes and Elevated Hemoglobin A1c Levels Are Associated with Brain Hypometabolism but Not Amyloid Accumulation

(2014) R. O. Roberts et al.   JOURNAL OF NUCLEAR MEDICINE

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

Recommendations of the Alzheimer's Disease-Related Dementias Conference

(2014) T. J. Montine et al.   NEUROLOGY

Brain glucose transporters: Implications for neurologic disease

(2014) E. E. Benarroch   NEUROLOGY

The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging

(2014) Christopher M. Marano et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Cardiovascular risk factors and frontotemporal dementia: a case–control study

(2014) Angel Golimstok et al.   Translational Neurodegeneration

Evidence for altered transport of insulin across the blood–brain barrier in insulin-resistant humans

(2013) Martin Heni et al.   ACTA DIABETOLOGICA

Increased Alzheimer’s Disease Neuropathology is Associated with Type 2 Diabetes and ApoE ε4 Carrier Status

(2013) Michael Malek-Ahmadi et al.   Current Alzheimer Research

Enhancement of Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes

(2013) Vera Novak et al.   DIABETES CARE

Type 2 Diabetes as a Risk Factor for Alzheimer's Disease: The Confounders, Interactions, and Neuropathology Associated With This Relationship

(2013) N. T. Vagelatos et al.   EPIDEMIOLOGIC REVIEWS

Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation

(2013) Thomas M. Schilling et al.   HUMAN BRAIN MAPPING

Intranasal Insulin Suppresses Systemic but Not Subcutaneous Lipolysis in Healthy Humans

(2013) K. Alexander Iwen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

(2013) Fernanda G. De Felice   JOURNAL OF CLINICAL INVESTIGATION

Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging

(2013) Madhav Thambisetty et al.   NEUROBIOLOGY OF AGING

Impaired glycemia increases disease progression in mild cognitive impairment

(2013) Jill K. Morris et al.   NEUROBIOLOGY OF AGING

Glucose Levels and Risk of Dementia

(2013) Paul K. Crane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diabetes is associated with postural instability and gait difficulty in Parkinson disease

(2013) Vikas Kotagal et al.   PARKINSONISM & RELATED DISORDERS

Altered baseline brain activity in type 2 diabetes: A resting-state fMRI study

(2013) Wenqing Xia et al.   PSYCHONEUROENDOCRINOLOGY

Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice

(2013) Juan Jose Ramos-Rodriguez et al.   PSYCHONEUROENDOCRINOLOGY

Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies

(2013) Kapil Gudala et al.   Journal of Diabetes Investigation

Glucose Intolerance, Insulin Resistance, and Pathological Features of Alzheimer Disease in the Baltimore Longitudinal Study of Aging

(2013) Madhav Thambisetty et al.   JAMA Neurology

Diabetes, Glucose Control, and 9-Year Cognitive Decline Among Older Adults Without Dementia

(2012) Kristine Yaffe et al.   ARCHIVES OF NEUROLOGY

Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease

(2012) Rajesh Chaudhary et al.   Cardiovascular Diabetology

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Resting-State Brain Functional Connectivity Is Altered in Type 2 Diabetes

(2012) G. Musen et al.   DIABETES

Impaired Insulin Sensitivity as Indexed by the HOMA Score Is Associated With Deficits in Verbal Fluency and Temporal Lobe Gray Matter Volume in the Elderly

(2012) C. Benedict et al.   DIABETES CARE

Risk of Parkinson Disease Onset in Patients With Diabetes: A 9-year population-based cohort study with age and sex stratifications

(2012) Y. Sun et al.   DIABETES CARE

Insulin Resistance, Brain Atrophy, and Cognitive Performance in Late Middle-Aged Adults

(2012) A. A. Willette et al.   DIABETES CARE

Brain accumulation of amyloid β protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus

(2012) Naoki Tomita et al.   Geriatrics & Gerontology International

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebral haemodynamics, cognition and brain volumes in patients with type 2 diabetes

(2012) Manon Brundel et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Dementia is associated with Insulin Resistance in patients with Parkinson's Disease

(2012) Domenico Bosco et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Diabetes and risk of Parkinson's disease

(2012) Emanuele Cereda et al.   MOVEMENT DISORDERS

Clinical features of Parkinson disease when onset of diabetes came first: A case-control study

(2012) E. Cereda et al.   NEUROLOGY

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort

(2012) Mark L. Wahlqvist et al.   PARKINSONISM & RELATED DISORDERS

Obesity and Metabolic Syndrome and Functional and Structural Brain Impairments in Adolescence

(2012) P. L. Yau et al.   PEDIATRICS

Insulin in the brain: There and back again

(2012) William A. Banks et al.   PHARMACOLOGY & THERAPEUTICS

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis

(2011) Thomas Scherer et al.   Cell Metabolism

Rosiglitazone Does Not Improve Cognition or Global Function when Used as Adjunctive Therapy to AChE Inhibitors in Mild-to-Moderate Alzheimers Disease: Two Phase 3 Studies

(2011) C. Harrington et al.   Current Alzheimer Research

Diabetes and Risk of Parkinson's Disease

(2011) Q. Xu et al.   DIABETES CARE

Association of Metabolic Dysregulation With Volumetric Brain Magnetic Resonance Imaging and Cognitive Markers of Subclinical Brain Aging in Middle-Aged Adults

(2011) Zaldy S. Tan et al.   DIABETES CARE

Type 2 diabetes affects hippocampus volume differentially in men and women

(2011) R. Hempel et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Glucose tolerance status and risk of dementia in the community: The Hisayama Study

(2011) T. Ohara et al.   NEUROLOGY

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

(2011) Cheng-Che Lee et al.   NEUROPHARMACOLOGY

Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes

(2011) Martin Heni et al.   PLoS One

Mid-life and late-life vascular risk factors and dementia in Korean men and women

(2010) H. Kimm et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Euglycemic Infusion of Insulin Detemir Compared With Human Insulin Appears to Increase Direct Current Brain Potential Response and Reduces Food Intake While Inducing Similar Systemic Effects

(2010) M. Hallschmid et al.   DIABETES

Diabetic Retinopathy and Cognitive Decline in Older People With Type 2 Diabetes: The Edinburgh Type 2 Diabetes Study

(2010) J. Ding et al.   DIABETES

Preliminary evidence for brain complications in obese adolescents with type 2 diabetes mellitus

(2010) P. L. Yau et al.   DIABETOLOGIA

Role of glycogen synthase kinase-3 in Alzheimer’s disease pathogenesis and glycogen synthase kinase-3 inhibitors

(2010) Jesús Avila et al.   Expert Review of Neurotherapeutics

Comparable Sensitivity of Postmenopausal and Young Women to the Effects of Intranasal Insulin on Food Intake and Working Memory

(2010) Rosemarie Krug et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cerebrospinal fluid insulin during non-neurological surgery

(2010) Sara Bromander et al.   JOURNAL OF NEURAL TRANSMISSION

Response of Human Oligodendrocyte Progenitors to Growth Factors and Axon Signals

(2010) Qiao Ling Cui et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-  Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex

(2010) R. F. Lane et al.   JOURNAL OF NEUROSCIENCE

Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

(2010) E. M. C. Schrijvers et al.   NEUROLOGY

Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study

(2010) S. Ahtiluoto et al.   NEUROLOGY

Mini-review: Impact of recurrent hypoglycemia on cognitive and brain function

(2010) Ewan C. McNay et al.   PHYSIOLOGY & BEHAVIOR

Evaluation of the lack of anorectic effect of intracerebroventricular insulin in rats

(2009) Lene Jessen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Different Patterns of Cerebral Injury in Dementia With or Without Diabetes

(2009) Joshua A. Sonnen   ARCHIVES OF NEUROLOGY

Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent

(2009) C.A. Grillo et al.   BRAIN RESEARCH

Cognition in the Early Stage of Type 2 Diabetes

(2009) C. Ruis et al.   DIABETES CARE

Regulation of insulin secretion: a matter of phase control and amplitude modulation

(2009) J. C. Henquin   DIABETOLOGIA

Insulin Modulates Food-Related Activity in the Central Nervous System

(2009) Martina Guthoff et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease

(2009) Natalie L. Rasgon et al.   NEUROBIOLOGY OF AGING

Akt signal transduction dysfunction in Parkinson's disease

(2009) Suzanne Timmons et al.   NEUROSCIENCE LETTERS

Human cerebral neuropathology of Type 2 diabetes mellitus

(2008) Peter T. Nelson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mid- and Late-Life Diabetes in Relation to the Risk of Dementia: A Population-Based Twin Study

(2008) W. Xu et al.   DIABETES

Depression and Type 2 Diabetes Over the Lifespan: A meta-analysis

(2008) B. Mezuk et al.   DIABETES CARE

Investigation on the relationship between diabetes mellitus type 2 and cognitive impairment

(2008) S.A. Ebady et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair

(2008) Thomas. J. Nelson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Genomic convergence to identify candidate genes for Alzheimer Disease on chromosome 10

(2008) Xueying Liang et al.   HUMAN MUTATION

Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin

(2008) Christian Benedict et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology

(2008) M. S. Beeri et al.   NEUROLOGY

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

β-Amyloid deposition in brains of subjects with diabetes

(2008) I. Alafuzoff et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neocortical glial cell numbers in human brains

(2007) D.P. Pelvig et al.   NEUROBIOLOGY OF AGING