TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity

Targeted inhibition of CD74 attenuates adipose COX-2-MIF-mediated M1 macrophage polarization and retards obesity-related adipose tissue inflammation and insulin resistance

(2018) Pei-Chi Chan et al.   CLINICAL SCIENCE

Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination

(2018) Kimberley D. Bruce et al.   Frontiers in Molecular Neuroscience

The Kaleidoscope of Microglial Phenotypes

(2018) Marissa L. Dubbelaar et al.   Frontiers in Immunology

Associations of Weight Gain From Early to Middle Adulthood With Major Health Outcomes Later in Life

(2017) Yan Zheng et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory

(2017) Sarah J. Spencer et al.   NEUROBIOLOGY OF AGING

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation

(2017) Vidhu Mathur et al.   NEURON

Microglia: An Interface between the Loss of Neuroplasticity and Depression

(2017) Gaurav Singhal et al.   Frontiers in Cellular Neuroscience

Hepatic Dysfunction Caused by Consumption of a High-Fat Diet

(2017) Anthony R. Soltis et al.   Cell Reports

Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity

(2017) Yuanqing Gao et al.   Cell Reports

Microglia activation due to obesity programs metabolic failure leading to type two diabetes

(2017) R Maldonado-Ruiz et al.   Nutrition & Diabetes

Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice

(2017) Amy Christensen et al.   PLoS One

Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology

(2016) Elodie Martin et al.   AGING CELL

Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity

(2016) Shuai Hao et al.   BRAIN BEHAVIOR AND IMMUNITY

Long-Term Consumption of High-Fat Diet in Rats: Effects on Microglial and Astrocytic Morphology and Neuronal Nitric Oxide Synthase Expression

(2016) Kinga Gzielo et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

High-fat diet feeding differentially affects the development of inflammation in the central nervous system

(2016) Owein Guillemot-Legris et al.   Journal of Neuroinflammation

Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning

(2016) Simone N. De Luca et al.   Journal of Neuroinflammation

TAK-242, an Antagonist for Toll-like Receptor 4, Protects against Acute Cerebral Ischemia/Reperfusion Injury in Mice

(2015) Fang Hua et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Lipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation

(2015) Jong In Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function

(2015) Miriam E. Bocarsly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic inflammation and gliosis in obesity

(2015) Mauricio D. Dorfman et al.   Current Opinion in Endocrinology Diabetes and Obesity

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation

(2015) Masato Maesako et al.   PLoS One

Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats

(2015) Ning Zhang et al.   PLoS One

Diet-induced obesity attenuates cytokine production following an immune challenge

(2014) Katherine M. Baumgarner et al.   BEHAVIOURAL BRAIN RESEARCH

MIF Receptor CD74 is Restricted to Microglia/Macrophages, Associated with a M1-Polarized Immune Milieu and Prolonged Patient Survival in Gliomas

(2014) Pia S. Zeiner et al.   BRAIN PATHOLOGY

The association between obesity and fluid intelligence impairment is mediated by chronic low-grade inflammation

(2014) Eirini C. Spyridaki et al.   BRITISH JOURNAL OF NUTRITION

Experimental immunology Diet-induced obesity mediates a proinflammatory response in pancreatic β cell via toll-like receptor 4

(2014) Juan Li et al.   Central European Journal of Immunology

Fractalkine (CX3CL1) Is Involved in the Early Activation of Hypothalamic Inflammation in Experimental Obesity

(2014) Joseane Morari et al.   DIABETES

Toll-like receptor 4 modulates cell migration and cortical neurogenesis after focal cerebral ischemia

(2014) Ana Moraga et al.   FASEB JOURNAL

Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats

(2014) Ted M. Hsu et al.   HIPPOCAMPUS

Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function

(2014) Anusha Jayaraman et al.   Journal of Neuroinflammation

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

(2014) L.-G. Bodea et al.   JOURNAL OF NEUROSCIENCE

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampus

(2014) Shunsuke Koga et al.   NEUROSCIENCE LETTERS

Regulation of Insulin Degrading Enzyme Activity by Obesity-Associated Factors and Pioglitazone in Liver of Diet-Induced Obese Mice

(2014) Xiuqing Wei et al.   PLoS One

TLR4-mediated brain inflammation halts neurogenesis: impact of hormonal replacement therapy

(2014) Abdeslam Mouihate   Frontiers in Cellular Neuroscience

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

(2014) Lin Jia et al.   Nature Communications

Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis

(2014) Isabelle K. Vila et al.   Cell Reports

A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species

(2014) Céline Vaure et al.   Frontiers in Immunology

The neuropathology of obesity: insights from human disease

(2013) Edward B. Lee et al.   ACTA NEUROPATHOLOGICA

Toll-Like Receptor 4 Mutation Protects Obese Mice Against Endothelial Dysfunction by Decreasing NADPH Oxidase Isoforms 1 and 4

(2013) Chao-Fan Liang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance

(2013) Byung-Cheol Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system

(2013) Laura B. Buckman et al.   BRAIN BEHAVIOR AND IMMUNITY

Androgens Increase Survival of Adult-Born Neurons in the Dentate Gyrus by an Androgen Receptor-Dependent Mechanism in Male Rats

(2013) D. K. Hamson et al.   ENDOCRINOLOGY

Effects of central and peripheral inflammation on hippocampal synaptic plasticity

(2013) Massimiliano Di Filippo et al.   NEUROBIOLOGY OF DISEASE

Spatial memory impairment and changes in hippocampal morphology are triggered by high-fat diets in adolescent mice. Is there a role of leptin?

(2013) Ismael Valladolid-Acebes et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Chronic Intermittent Fasting Improves Cognitive Functions and Brain Structures in Mice

(2013) Liaoliao Li et al.   PLoS One

Sex-Specific Effects of High Fat Diet on Indices of Metabolic Syndrome in 3xTg-AD Mice: Implications for Alzheimer's Disease

(2013) Anna M. Barron et al.   PLoS One

Methylphenidate prevents high-fat diet (HFD)-induced learning/memory impairment in juvenile mice

(2013) Melissa M. Kaczmarczyk et al.   PSYCHONEUROENDOCRINOLOGY

Toll-Like Receptor 4 Deficiency Decreases Atherosclerosis But Does Not Protect Against Inflammation in Obese Low-Density Lipoprotein Receptor–Deficient Mice

(2012) Yilei Ding et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effect of western and high fat diets on memory and cholinergic measures in the rat

(2012) Sepideh Kosari et al.   BEHAVIOURAL BRAIN RESEARCH

Neurogenesis, inflammation and behavior

(2012) Rachel A. Kohman et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

(2012) M. Milanski et al.   DIABETES

Hypothalamic Astrocytes in Obesity

(2012) Cristina García-Cáceres et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2012) Masato Maesako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Olfactory ability and object memory in three mouse models of varying body weight, metabolic hormones, and adiposity

(2012) Kristal R. Tucker et al.   PHYSIOLOGY & BEHAVIOR

An Automated Method to Quantify Microglia Morphology and Application to Monitor Activation State Longitudinally In Vivo

(2012) Cleopatra Kozlowski et al.   PLoS One

Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling

(2011) Zhen Wang et al.   BRITISH JOURNAL OF NUTRITION

Microglia Phenotype Diversity

(2011) M. Olah et al.   CNS & Neurological Disorders-Drug Targets

Obesity-dependent cannabinoid modulation of proliferation in adult neurogenic regions

(2011) Patricia Rivera et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

(2011) Carlo Perego et al.   Journal of Neuroinflammation

Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway

(2011) Leonid Tarassishin et al.   Journal of Neuroinflammation

Reduced Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus of High Fat Diet-Fed Mice are Ameliorated by Metformin and Glimepiride Treatment

(2011) Dae Young Yoo et al.   NEUROCHEMICAL RESEARCH

Fasting Induces an Anti-Inflammatory Effect on the Neuroimmune System Which a High-Fat Diet Prevents

(2011) Desiree N. Lavin et al.   Obesity

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Continuous and Cyclic Progesterone Differentially Interact with Estradiol in the Regulation of Alzheimer-Like Pathology in Female 3×Transgenic-Alzheimer’s Disease Mice

(2010) Jenna C. Carroll et al.   ENDOCRINOLOGY

Neprilysin, obesity and the metabolic syndrome

(2010) K F Standeven et al.   INTERNATIONAL JOURNAL OF OBESITY

Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet.

(2010) Scott E. Kanoski et al.   JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL LEARNING AND COGNITION

Obesity is linked with lower brain volume in 700 AD and MCI patients

(2010) April J. Ho et al.   NEUROBIOLOGY OF AGING

A high-fat diet impairs neurogenesis: Involvement of lipid peroxidation and brain-derived neurotrophic factor

(2010) Hee Ra Park et al.   NEUROSCIENCE LETTERS

MHC Class II Molecules Enhance Toll-Like Receptor Mediated Innate Immune Responses

(2010) Remo Frei et al.   PLoS One

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Diet-induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring

(2009) Yusuke Tozuka et al.   FASEB JOURNAL

Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding

(2009) Andrew J. Murray et al.   FASEB JOURNAL

Diet-induced obesity increases NF-κB signaling in reporter mice

(2009) Harald Carlsen et al.   Genes and Nutrition

Obesity, Inflammation, and Insulin Resistance – A Mini-Review

(2009) Maximilian Zeyda et al.   GERONTOLOGY

Cognitive impairment following high fat diet consumption is associated with brain inflammation

(2009) Paul J. Pistell et al.   JOURNAL OF NEUROIMMUNOLOGY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Effects of High Cholesterol Diet on Newly Generated Cells in the Dentate Gyrus of C57BL/6N and C3H/HeN Mice

(2009) Il Yong KIM et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Age-related changes in serum and brain levels of androgens in male Brown Norway rats

(2009) Emily R. Rosario et al.   NEUROREPORT

Sex Differences in High-fat Diet-induced Obesity, Metabolic Alterations and Learning, and Synaptic Plasticity Deficits in Mice

(2009) Ling-Ling Hwang et al.   Obesity

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice

(2008) K. R. Coenen et al.   DIABETOLOGIA

In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia

(2008) Emanuele Cacci et al.   GLIA

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

(2008) Alexis M. Stranahan et al.   HIPPOCAMPUS

Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-κB pathway in adipocytes links nutritional signalling with innate immunity

(2008) Andreas Schaeffler et al.   IMMUNOLOGY

Interactions between APP secretases and inflammatory mediators

(2008) Magdalena Sastre et al.   Journal of Neuroinflammation

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

Brain inflammation and adult neurogenesis: The dual role of microglia

(2008) C.T. Ekdahl et al.   NEUROSCIENCE

Diet-induced obesity and spatial cognition in young male rats

(2008) Nicole Jurdak et al.   NUTRITIONAL NEUROSCIENCE