Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease
Authors
Keywords
-
Journal
DIABETES
Volume 63, Issue 7, Pages 2262-2272
Publisher
American Diabetes Association
Online
2014-06-16
DOI
10.2337/db13-1954
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease
- (2014) Sergio T. Ferreira et al. Alzheimers & Dementia
- Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling: Figure 1
- (2013) Fei Yin et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys
- (2013) Mychael V. Lourenco et al. Cell Metabolism
- Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
- (2013) Jessica Freiherr et al. CNS DRUGS
- Alzheimer’s disease and insulin resistance: translating basic science into clinical applications
- (2013) Fernanda G. De Felice JOURNAL OF CLINICAL INVESTIGATION
- Turning off the inflammatory, but not the metabolic, flames
- (2013) Ediz S. Calay et al. NATURE MEDICINE
- Oxidative stress and the ageing endocrine system
- (2013) Giovanni Vitale et al. Nature Reviews Endocrinology
- Increased blood–brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model
- (2013) Shuko Takeda et al. NEUROBIOLOGY OF AGING
- Higher glucose levels associated with lower memory and reduced hippocampal microstructure
- (2013) L. Kerti et al. NEUROLOGY
- Glucose Levels and Risk of Dementia
- (2013) Paul K. Crane et al. NEW ENGLAND JOURNAL OF MEDICINE
- Diabetes drugs and neurological disorders: new views and therapeutic possibilities
- (2013) Cesare Patrone et al. Lancet Diabetes & Endocrinology
- Mechanisms for Insulin Resistance: Common Threads and Missing Links
- (2012) Varman T. Samuel et al. CELL
- Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease
- (2012) Mark P. Mattson Cell Metabolism
- Impaired Insulin Sensitivity as Indexed by the HOMA Score Is Associated With Deficits in Verbal Fluency and Temporal Lobe Gray Matter Volume in the Elderly
- (2012) C. Benedict et al. DIABETES CARE
- Insulin Has Multiple Antiamyloidogenic Effects on Human Neuronal Cells
- (2012) Giuseppe Pandini et al. ENDOCRINOLOGY
- An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
- (2012) Theresa R. Bomfim et al. JOURNAL OF CLINICAL INVESTIGATION
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
- (2012) Konrad Talbot et al. JOURNAL OF CLINICAL INVESTIGATION
- Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer’s disease neuropathology
- (2012) Nicole L Bjorklund et al. Molecular Neurodegeneration
- Insulin resistance and AD—extending the translational path
- (2012) Suzanne Craft Nature Reviews Neurology
- The many faces of insulin-like peptide signalling in the brain
- (2012) Ana M. Fernandez et al. NATURE REVIEWS NEUROSCIENCE
- Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis
- (2012) D. Sebastian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin-activated Akt rescues Aβ oxidative stress-induced cell death by orchestrating molecular trafficking
- (2011) Pasquale Picone et al. AGING CELL
- Inflammatory Mechanisms in Obesity
- (2011) Margaret F. Gregor et al. Annual Review of Immunology
- Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment
- (2011) Suzanne Craft ARCHIVES OF NEUROLOGY
- Cognition and Neuropathology in Aging: Multidimensional Perspectives from the Rush Religious Orders Study and Rush Memory and Aging Project
- (2011) S. Negash et al. Current Alzheimer Research
- Low-Grade Hypothalamic Inflammation Leads to Defective Thermogenesis, Insulin Resistance, and Impaired Insulin Secretion
- (2011) Ana Paula Arruda et al. ENDOCRINOLOGY
- Altered hypothalamic function in diet-induced obesity
- (2011) L A Velloso et al. INTERNATIONAL JOURNAL OF OBESITY
- Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice
- (2011) William L. Holland et al. JOURNAL OF CLINICAL INVESTIGATION
- Obesity is associated with hypothalamic injury in rodents and humans
- (2011) Joshua P. Thaler et al. JOURNAL OF CLINICAL INVESTIGATION
- The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease
- (2011) P. L. McClean et al. JOURNAL OF NEUROSCIENCE
- Resolving controversies on the path to Alzheimer's therapeutics
- (2011) Dennis J Selkoe NATURE MEDICINE
- The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease
- (2011) Sergio T. Ferreira et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress
- (2011) S. Purkayastha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes
- (2010) Laura D. Baker et al. ARCHIVES OF NEUROLOGY
- A Meta-Analysis of Cytokines in Alzheimer's Disease
- (2010) Walter Swardfager et al. BIOLOGICAL PSYCHIATRY
- Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis
- (2010) Takahisa Nakamura et al. CELL
- Adiponectin in plasma and cerebrospinal fluid in MCI and Alzheimer’s disease
- (2010) K. Une et al. EUROPEAN JOURNAL OF NEUROLOGY
- High-molecular-weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients
- (2010) Hiroaki Fukumoto et al. FASEB JOURNAL
- The procognitive effects of leptin in the brain and their clinical implications
- (2010) G. Paz-Filho et al. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
- N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid-β peptide oligomers
- (2010) Helena Decker et al. JOURNAL OF NEUROCHEMISTRY
- Reimagining Alzheimer's Disease--An Age-Based Hypothesis
- (2010) K. Herrup JOURNAL OF NEUROSCIENCE
- Microglia in neurodegenerative disease
- (2010) V. Hugh Perry et al. Nature Reviews Neurology
- Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study
- (2010) T. Matsuzaki et al. NEUROLOGY
- Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A deposition in an Alzheimer mouse model with diabetes
- (2010) S. Takeda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin signaling meets mitochondria in metabolism
- (2010) Zhiyong Cheng et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus
- (2009) Jeroen J.M. Hoozemans et al. AMERICAN JOURNAL OF PATHOLOGY
- Different Patterns of Cerebral Injury in Dementia With or Without Diabetes
- (2009) Joshua A. Sonnen ARCHIVES OF NEUROLOGY
- Intracerebroventricular insulin improves spatial learning and memory in male Wistar rats.
- (2009) V. Haj-ali et al. BEHAVIORAL NEUROSCIENCE
- Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
- (2009) Talib Abbas et al. BEHAVIOURAL BRAIN RESEARCH
- Reactive Oxygen Species Enhance Insulin Sensitivity
- (2009) Kim Loh et al. Cell Metabolism
- Amyloid Deposition and Inflammation in APPswe/PS1dE9 Mouse Model of Alzheimers Disease
- (2009) Lingfei Ruan et al. Current Alzheimer Research
- Overweight in midlife and risk of dementia: a 40-year follow-up study
- (2009) L B Hassing et al. INTERNATIONAL JOURNAL OF OBESITY
- Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging
- (2009) Wolfgang Lieb JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
- (2009) Ethan J. Anderson et al. JOURNAL OF CLINICAL INVESTIGATION
- -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin
- (2009) Q.-L. Ma et al. JOURNAL OF NEUROSCIENCE
- Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity
- (2009) M. Milanski et al. JOURNAL OF NEUROSCIENCE
- Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers
- (2009) Fernanda G. De Felice et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Leptin reduces Alzheimer’s disease-related tau phosphorylation in neuronal cells
- (2008) Steven J. Greco et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
- (2008) Xiaoqing Zhang et al. CELL
- Fat intake at midlife and cognitive impairment later in life: a population‐based CAIDE study
- (2008) Marjo H. Eskelinen et al. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
- Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment
- (2008) Pamela Osenkowski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
- (2008) Aileen M. Moloney et al. NEUROBIOLOGY OF AGING
- Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo
- (2008) Shu-Ling Chiu et al. NEURON
- Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis
- (2008) M. A. Beydoun et al. Obesity Reviews
- Amyloid beta oligomers induce impairment of neuronal insulin receptors
- (2007) Wei-Qin Zhao et al. FASEB JOURNAL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now