Microglial Phenotype and Adaptation

Cytokine-Mediated Inhibition of Fibrillar Amyloid-  Peptide Degradation by Human Mononuclear Phagocytes

(2014) M. Yamamoto et al.   JOURNAL OF IMMUNOLOGY

Carcinoma cells misuse the host tissue damage response to invade the brain

(2013) Han-Ning Chuang et al.   GLIA

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Brain microglia: watchdogs with pedigree

(2013) Harald Neumann et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Functional diversity of microglia – how heterogeneous are they to begin with?

(2013) Uwe-Karsten Hanisch   Frontiers in Cellular Neuroscience

Histone Deacetylase Inhibitors: New Promise in the Treatment of Immune and Inflammatory Diseases

(2012) Stephen J. Shuttleworth et al.   CURRENT DRUG TARGETS

TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment

(2012) Shai Abutbul et al.   GLIA

Comparison of polarization properties of human adult microglia and blood-derived macrophages

(2012) Bryce A. Durafourt et al.   GLIA

Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia

(2012) Jörg Scheffel et al.   GLIA

Phenotyping primary human microglia: Tight regulation of LPS responsiveness

(2012) Jeroen Melief et al.   GLIA

Development and homeostasis of “resident” myeloid cells: The case of the microglia

(2012) Elisa Gomez Perdiguero et al.   GLIA

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Migration of monocytes after intracerebral injection at entorhinal cortex lesion site

(2012) Miriam Kaminski et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia

(2012) Ursula Püntener et al.   Journal of Neuroinflammation

TGFβ signalling plays an important role in IL4-induced alternative activation of microglia

(2012) Xiaolai Zhou et al.   Journal of Neuroinflammation

Deciphering the transcriptional network of the dendritic cell lineage

(2012) Jennifer C Miller et al.   NATURE IMMUNOLOGY

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

The molecular profile of microglia under the influence of glioma

(2012) W. Li et al.   NEURO-ONCOLOGY

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

C3-dependent mechanism of microglial priming relevant to multiple sclerosis

(2012) V. Ramaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells

(2012) N. H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Non-Identical Twins – Microglia and Monocyte-Derived Macrophages in Acute Injury and Autoimmune Inflammation

(2012) Steffen Jung et al.   Frontiers in Immunology

Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

(2011) Ashley M. Fenn et al.   BRAIN BEHAVIOR AND IMMUNITY

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Microglia Phenotype Diversity

(2011) M. Olah et al.   CNS & Neurological Disorders-Drug Targets

AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice

(2011) T Kiyota et al.   GENE THERAPY

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Long-lasting protection in brain trauma by endotoxin preconditioning

(2011) Luca Longhi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Lifespan Approach to Neuroinflammatory and Cognitive Disorders: A Critical Role for Glia

(2011) Staci D. Bilbo et al.   Journal of Neuroimmune Pharmacology

Microglia and Memory: Modulation by Early-Life Infection

(2011) L. L. Williamson et al.   JOURNAL OF NEUROSCIENCE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Translational Neurodegeneration, a platform to share knowledge and experience in translational study of neurodegenerative diseases

(2011) Shengdi Chen et al.   Translational Neurodegeneration

CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system

(2010) Carolin Prodinger et al.   ACTA NEUROPATHOLOGICA

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge

(2010) Angela M. Wynne et al.   BRAIN BEHAVIOR AND IMMUNITY

CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer’s disease-like pathogenesis in APP+PS1 bigenic mice

(2010) Tomomi Kiyota et al.   FASEB JOURNAL

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

(2010) Miho Shiratori et al.   JOURNAL OF NEUROCHEMISTRY

Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE

(2010) Beatriz Almolda et al.   JOURNAL OF NEUROIMMUNOLOGY

The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

(2010) S. Jha et al.   JOURNAL OF NEUROSCIENCE

Adenosine A1 Receptor Activation as a Brake on the Microglial Response after Experimental Traumatic Brain Injury in Mice

(2010) M. Lee Haselkorn et al.   JOURNAL OF NEUROTRAUMA

Maintenance of anti-inflammatory cytokines and reduction of glial activation in the ischemic hippocampal CA1 region preconditioned with lipopolysaccharide

(2010) Jia Tian Yu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice

(2010) Martine M. Mirrione et al.   NEUROBIOLOGY OF DISEASE

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

(2010) M. T. Heneka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

IL-4/IL-13-Dependent Alternative Activation of Macrophages but Not Microglial Cells Is Associated with Uncontrolled Cerebral Cryptococcosis

(2009) Werner Stenzel et al.   AMERICAN JOURNAL OF PATHOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Brain dendritic cells in ischemic stroke: Time course, activation state, and origin

(2009) Jennifer C. Felger et al.   BRAIN BEHAVIOR AND IMMUNITY

Glial glucocorticoid receptors in aged Fisher 344 (F344) and F344/Brown Norway rats

(2009) J. Kasckow et al.   EXPERIMENTAL GERONTOLOGY

An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease

(2009) Bruno P Imbimbo   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Microglia and neuropathic pain

(2009) Kazuhide Inoue et al.   GLIA

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The NF-κB Factor RelB and Histone H3 Lysine Methyltransferase G9a Directly Interact to Generate Epigenetic Silencing in Endotoxin Tolerance

(2009) Xiaoping Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activationin vivoandin vitro

(2009) Anthony Lyons et al.   JOURNAL OF NEUROCHEMISTRY

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Enduring Reversal of Neuropathic Pain by a Single Intrathecal Injection of Adenosine 2A Receptor Agonists: A Novel Therapy for Neuropathic Pain

(2009) L. C. Loram et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats

(2009) Adam D. Bachstetter et al.   NEUROBIOLOGY OF AGING

Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo

(2009) Giuseppe Faraco et al.   NEUROBIOLOGY OF DISEASE

Behavioural and Histological Effects of Preconditioning with Lipopolysaccharide in Epileptic Rats

(2009) Mirosława Dmowska et al.   NEUROCHEMICAL RESEARCH

Acute in vivo exposure to interferon-  enables resident brain dendritic cells to become effective antigen presenting cells

(2009) A. Gottfried-Blackmore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

(2009) D. S. Markovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research

(2009) Sang-Ho Choi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS

(2008) Alexander H. de Haas et al.   GLIA

Structures of the Toll-like Receptor Family and Its Ligand Complexes

(2008) Mi Sun Jin et al.   IMMUNITY

Cytokine Signaling Modules in Inflammatory Responses

(2008) John J. O'Shea et al.   IMMUNITY

G9a and HP1 Couple Histone and DNA Methylation to TNFα Transcription Silencing during Endotoxin Tolerance

(2008) Mohamed El Gazzar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: A retrospective cohort study

(2008) Mahyar Etminan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain

(2008) Karen Bulloch et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Activation of P2X7receptors induces CCL3 production in microglial cells through transcription factor NFAT

(2008) Ayako Kataoka et al.   JOURNAL OF NEUROCHEMISTRY

A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS

(2008) S. Lehnardt et al.   JOURNAL OF NEUROSCIENCE

Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic

(2008) S. Jimenez et al.   JOURNAL OF NEUROSCIENCE

Surgical excision of CNS-draining lymph nodes reduces relapse severity in chronic-relapsing experimental autoimmune encephalomyelitis

(2008) Marloes van Zwam et al.   JOURNAL OF PATHOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Toll-like receptors — taking an evolutionary approach

(2008) François Leulier et al.   NATURE REVIEWS GENETICS

Can the immune system be harnessed to repair the CNS?

(2008) Phillip G. Popovich et al.   NATURE REVIEWS NEUROSCIENCE

Comparison of Ionized Calcium-binding Adapter Molecule 1 Immunoreactivity of the Hippocampal Dentate Gyrus and CA1 Region in Adult and Aged Dogs

(2008) In Koo Hwang et al.   NEUROCHEMICAL RESEARCH

Aging attenuates glucocorticoid negative feedback in rat brain

(2008) K. Mizoguchi et al.   NEUROSCIENCE

Purinergic signalling in the nervous system: an overview

(2008) Maria P. Abbracchio et al.   TRENDS IN NEUROSCIENCES

Neonatal and adult microglia cross-present exogenous antigens

(2007) Celine Beauvillain et al.   GLIA