Obesity and dysregulated central and peripheral macrophage-neuron cross-talk

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

(2018) Graeme I. Lancaster et al.   Cell Metabolism

Niche signals and transcription factors involved in tissue-resident macrophage development

(2018) Wouter T'Jonck et al.   CELLULAR IMMUNOLOGY

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses

(2018) Lily Boutens et al.   DIABETOLOGIA

Insulin resistance causes inflammation in adipose tissue

(2018) Mitsugu Shimobayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell and molecular mechanisms behind diet-induced hypothalamic inflammation and obesity

(2018) Yenniffer Ávalos et al.   JOURNAL OF NEUROENDOCRINOLOGY

Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies

(2018) Zhana Haimon et al.   NATURE IMMUNOLOGY

Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue

(2018) Vlad Serbulea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages

(2017) Syed F. Hassnain Waqas et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages

(2017) Syed F. Hassnain Waqas et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity

(2017) Julia Braune et al.   JOURNAL OF IMMUNOLOGY

TFH-derived dopamine accelerates productive synapses in germinal centres

(2017) Ilenia Papa et al.   NATURE

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

(2017) Katrin Fischer et al.   NATURE MEDICINE

A molecular census of arcuate hypothalamus and median eminence cell types

(2017) John N Campbell et al.   NATURE NEUROSCIENCE

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

(2017) Mauricio D. Dorfman et al.   Nature Communications

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

(2016) Ilana Gabanyi et al.   CELL

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

(2016) Jong-Seok Moon et al.   NATURE MEDICINE

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Local proliferation initiates macrophage accumulation in adipose tissue during obesity

(2016) C Zheng et al.   Cell Death & Disease

Neuron–Microglia Interactions in Mental Health Disorders: “For Better, and For Worse”

(2016) Eric S. Wohleb   Frontiers in Immunology

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Sympathetic Nerve Activity Maintains an Anti-Inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF-α Gene Expression in Macrophages

(2015) Lijun Tang et al.   ENDOCRINOLOGY

Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)

(2015) Kenny L. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

(2015) Jong-Seok Moon et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypothalamic innate immune reaction in obesity

(2015) Stefanie Kälin et al.   Nature Reviews Endocrinology

A stratified myeloid system, the challenge of understanding macrophage diversity

(2015) F. Geissmann et al.   SEMINARS IN IMMUNOLOGY

Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance

(2014) Myriam Aouadi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

(2014) Paul Andrew Muller et al.   CELL

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

(2014) Prabhakara R. Nagareddy et al.   Cell Metabolism

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Fractalkine (CX3CL1) Is Involved in the Early Activation of Hypothalamic Inflammation in Experimental Obesity

(2014) Joseane Morari et al.   DIABETES

Neural innervation of white adipose tissue and the control of lipolysis

(2014) Timothy J. Bartness et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Hypothalamus-adipose tissue crosstalk: neuropeptide Y and the regulation of energy metabolism

(2014) Wei Zhang et al.   Nutrition & Metabolism

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

Local proliferation of macrophages in adipose tissue during obesity-induced inflammation

(2013) Julia Haase et al.   DIABETOLOGIA

Adipose Tissue Foam Cells Are Present in Human Obesity

(2013) Hagit Shapiro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages

(2013) Laurent L'homme et al.   JOURNAL OF LIPID RESEARCH

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Quantity of glucose transporter and appetite-associated factor mRNA in various tissues after insulin injection in chickens selected for low or high body weight

(2013) Wei Zhang et al.   PHYSIOLOGICAL GENOMICS

Neuropeptide Y Is Produced by Adipose Tissue Macrophages and Regulates Obesity-Induced Inflammation

(2013) Kanakadurga Singer et al.   PLoS One

Interleukin-1β Regulates Fat-Liver Crosstalk in Obesity by Auto-Paracrine Modulation of Adipose Tissue Inflammation and Expandability

(2013) Ori Nov et al.   PLoS One

In situ production of innate immune cells in murine white adipose tissue

(2012) S. Poglio et al.   BLOOD

Neuropeptide Y1 Receptor in Immune Cells Regulates Inflammation and Insulin Resistance Associated With Diet-Induced Obesity

(2012) L. Macia et al.   DIABETES

Identification of novel markers of alternative activation and potential endogenous PPARγ ligand production mechanisms in human IL-4 stimulated differentiating macrophages

(2012) Zsolt Czimmerer et al.   IMMUNOBIOLOGY

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation

(2012) Aarash Bordbar et al.   Molecular Systems Biology

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

NPY receptors as potential targets for anti-obesity drug development

(2011) Ernie Yulyaningsih et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice

(2011) Xavier Prieur et al.   DIABETES

Increased Macrophage Migration Into Adipose Tissue in Obese Mice

(2011) D. Y. Oh et al.   DIABETES

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Polymorphisms in the NPY2R Gene Show Significant Associations With BMI That Are Additive to FTO, MC4R, and NPFFR2 Gene Effects

(2011) Steven C. Hunt et al.   Obesity

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic potential of neuropeptide Y (NPY) receptor ligands

(2010) Shaun P. Brothers et al.   EMBO Molecular Medicine

Effects of pain controlling neuropeptides on human fat cell lipolysis

(2010) V van Harmelen et al.   INTERNATIONAL JOURNAL OF OBESITY

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

(2010) Aliki Kosteli et al.   JOURNAL OF CLINICAL INVESTIGATION

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid

(2010) Esteban M. Rodríguez et al.   PEPTIDES

Sympathetic nervous activation in obesity and the metabolic syndrome—Causes, consequences and therapeutic implications

(2010) Gavin W. Lambert et al.   PHARMACOLOGY & THERAPEUTICS

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity

(2010) R. R. Ricardo-Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Human Adipose Tissue Macrophages: M1 and M2 Cell Surface Markers in Subcutaneous and Omental Depots and after Weight Loss

(2009) Judith Aron-Wisnewsky et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

RFamide neuropeptides inhibit murine and human adipose differentiation

(2008) Mireya L. Herrera-Herrera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Transgenic Mice Overexpressing Neuropeptide Y in Noradrenergic Neurons: A Novel Model of Increased Adiposity and Impaired Glucose Tolerance

(2008) S. T. Ruohonen et al.   DIABETES

Neuropeptide Y is produced in visceral adipose tissue and promotes proliferation of adipocyte precursor cells via the Y1 receptor

(2008) Kaiping Yang et al.   FASEB JOURNAL

Neuropeptide Y promotes TGF-β1 production in RAW264.7 cells by activating PI3K pathway via Y1 receptor

(2008) Jiang-Rui Zhou et al.   Neuroscience Bulletin