Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer’s disease by remodeling peri-plaque astrocyte structure

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

(2018) Nazira J. Albargothy et al.   ACTA NEUROPATHOLOGICA

Reactive astrocytes in Alzheimer’s disease: A double-edged sword

(2018) Heejung Chun et al.   NEUROSCIENCE RESEARCH

Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden

(2018) Stephanie R. Rainey-Smith et al.   Translational Psychiatry

Loss of Astrocyte Polarization in the Tg-ArcSwe Mouse Model of Alzheimer's Disease

(2018) Jing Yang et al.   JOURNAL OF ALZHEIMERS DISEASE

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease

(2017) Angela Gomez-Arboledas et al.   GLIA

Human and mouse cortical astrocytes differ in aquaporin-4 polarization toward microvessels

(2017) Vigdis Andersen Eidsvaag et al.   GLIA

Sphingosine-1-phosphate induces Ca2+ signaling and CXCL1 release via TRPC6 channel in astrocytes

(2017) Hisashi Shirakawa et al.   GLIA

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow

(2017) Karl Erik Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

(2017) Douglas M. Zeppenfeld et al.   JAMA Neurology

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

(2016) Katherine R. Sadleir et al.   ACTA NEUROPATHOLOGICA

Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism

(2016) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

High Resolution Dissection of Reactive Glial Nets in Alzheimer’s Disease

(2016) David S. Bouvier et al.   Scientific Reports

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections

(2015) Alex J. Smith et al.   BIOPHYSICAL JOURNAL

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Elusive roles for reactive astrocytes in neurodegenerative diseases

(2015) Lucile Ben Haim et al.   Frontiers in Cellular Neuroscience

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Glia in the pathogenesis of neurodegenerative diseases

(2014) Alexei Verkhratsky et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Aggregation state determines the localization and function of M1– and M23–aquaporin-4 in astrocytes

(2014) Alex J. Smith et al.   JOURNAL OF CELL BIOLOGY

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

(2013) Patty C. Kandalepas et al.   ACTA NEUROPATHOLOGICA

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy

(2013) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

(2012) Andrew W. Kraft et al.   FASEB JOURNAL

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease

(2011) Chuanyu Li et al.   Current Alzheimer Research

The increased density of p38 mitogen-activated protein kinase-immunoreactive microglia in the sensorimotor cortex of aged TgCRND8 mice is associated predominantly with smaller dense-core amyloid plaques

(2011) J. Chlan-Fourney et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation

(2011) Lihua Li et al.   FASEB JOURNAL

Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-  Expression for Microglial A  Phagocytosis

(2011) D. Terwel et al.   JOURNAL OF NEUROSCIENCE

An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes

(2011) V. Benfenati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice

(2010) X. Mei et al.   NEUROSCIENCE

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema

(2010) A. S. Thrane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice

(2009) Lihua Li et al.   BMC NEUROSCIENCE

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

(2009) D.M. Wilcock et al.   NEUROSCIENCE

Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

(2008) Ditte Zerlang Christensen et al.   ACTA NEUROPATHOLOGICA

Binding and uptake of Aβ1-42 by primary human astrocytesin vitro

(2008) Henrietta M. Nielsen et al.   GLIA

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY