Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

Multiple Sclerosis

(2018) Daniel S. Reich et al.   NEW ENGLAND JOURNAL OF MEDICINE

A bloody brake on myelin repair

(2018) Klaus-Armin Nave et al.   NATURE

Differing associations between Aβ accumulation, hypoperfusion, blood–brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease

(2017) J Scott Miners et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation

(2017) Róisín M. McManus et al.   Journal of Neuroimmune Pharmacology

Vascular pathology in multiple sclerosis: reframing pathogenesis around the blood-brain barrier

(2017) Jonathan I Spencer et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Laquinimod enhances central nervous system barrier functions

(2017) Fred Lühder et al.   NEUROBIOLOGY OF DISEASE

Fibrinogen in the Nervous System: Glia Beware

(2017) Erin H. Norris et al.   NEURON

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage

(2017) Mark A. Petersen et al.   NEURON

White matter hyperintensities are seen only in GRN mutation carriers in the GENFI cohort

(2017) Carole H. Sudre et al.   NeuroImage-Clinical

Serial Susceptibility Weighted MRI Measures Brain Iron and Microbleeds in Dementia

(2017) Wolff Kirsch et al.   JOURNAL OF ALZHEIMERS DISEASE

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling

(2017) Angeliki Maria Nikolakopoulou et al.   PLoS One

Prothrombin and factor X are elevated in multiple sclerosis patients

(2016) Kerstin Göbel et al.   ANNALS OF NEUROLOGY

The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII: reply

(2016) D. Zamolodchikov et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII

(2016) D. Zamolodchikov et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study

(2016) Zoe Arvanitakis et al.   LANCET NEUROLOGY

BMP signalling in skeletal development, disease and repair

(2016) Valerie S. Salazar et al.   Nature Reviews Endocrinology

Elevated fibrinogen levels in neuromyelitis optica is associated with severity of disease

(2016) Ya Zhang et al.   NEUROLOGICAL SCIENCES

A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease

(2016) Daria Zamolodchikov et al.   THROMBOSIS RESEARCH

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

(2016) Kerstin Göbel et al.   Nature Communications

Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology

(2015) Janelle Drouin-Ouellet et al.   ANNALS OF NEUROLOGY

Multisite Thrombus Imaging and Fibrin Content Estimation With a Single Whole-Body PET Scan in RatsSignificance

(2015) Francesco Blasi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo

(2015) Michael P. Motley et al.   BLOOD

Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly

(2015) Prashanthi Vemuri et al.   BRAIN

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Dimethyl fumarate attenuates cerebral edema formation by protecting the blood–brain barrier integrity

(2015) Reiner Kunze et al.   EXPERIMENTAL NEUROLOGY

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

(2015) Silvia Tietz et al.   JOURNAL OF CELL BIOLOGY

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

(2015) Madison T Gray et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Frontotemporal lobar degeneration FTLD-tau: preclinical lesions, vascular, and Alzheimer-related co-pathologies

(2015) Dietmar Rudolf Thal et al.   JOURNAL OF NEURAL TRANSMISSION

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration

(2015) Marta Cortes-Canteli et al.   NEUROBIOLOGY OF AGING

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

(2015) Nga Bien-Ly et al.   NEURON

Activation of the factor XII-driven contact system in Alzheimer’s disease patient and mouse model plasma

(2015) Daria Zamolodchikov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaking boundaries—coagulation and fibrinolysis at the neurovascular interface

(2015) Sophia Bardehle et al.   Frontiers in Cellular Neuroscience

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

(2015) Jae Kyu Ryu et al.   Nature Communications

Increased cerebrospinal fluid fibrinogen in major depressive disorder

(2015) Kotaro Hattori et al.   Scientific Reports

Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles

(2015) Jeong-Yeon Kim et al.   Theranostics

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction

(2015) Ileana Soto et al.   PLOS BIOLOGY

Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder?

(2015) Jay P. Patel et al.   NEURAL PLASTICITY

Fingolimod Prevents Blood-Brain Barrier Disruption Induced by the Sera from Patients with Multiple Sclerosis

(2015) Hideaki Nishihara et al.   PLoS One

The formation of inflammatory demyelinated lesions in cerebral white matter

(2014) Pietro Maggi et al.   ANNALS OF NEUROLOGY

A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer’s disease mice

(2014) Hyung Jin Ahn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

(2014) Jeremy Chataway et al.   LANCET

Glial Development: The Crossroads of Regeneration and Repair in the CNS

(2014) Vittorio Gallo et al.   NEURON

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

(2014) E. A. Winkler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages

(2014) Guang Sheng Ling et al.   Nature Communications

Early detection of thrombin activity in neuroinflammatory disease

(2013) Dimitrios Davalos et al.   ANNALS OF NEUROLOGY

Optical imaging of fibrin deposition to elucidate participation of mast cells in foreign body responses

(2013) Yi-Ting Tsai et al.   BIOMATERIALS

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

The APOE ε4/ε4 Genotype Potentiates Vascular Fibrin(Ogen) Deposition in Amyloid-Laden Vessels in the Brains of Alzheimer's Disease Patients

(2013) Karin Hultman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tissue plasminogen activator arrests Alzheimer's disease pathogenesis

(2013) Shin Bi Oh et al.   NEUROBIOLOGY OF AGING

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Cleavage of Fibrinogen by Proteinases Elicits Allergic Responses Through Toll-Like Receptor 4

(2013) V. O. Millien et al.   SCIENCE

Protective effects of Batroxobin on spinal cord injury in rats

(2013) Hong Fan et al.   Neuroscience Bulletin

Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia

(2013) Debjani Tripathy et al.   Frontiers in Aging Neuroscience

Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

(2012) Ethan A. Winkler et al.   ACTA NEUROPATHOLOGICA

Ratiometric Activatable Cell-Penetrating Peptides Provide Rapid In Vivo Readout of Thrombin Activation

(2012) Michael Whitney et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A  delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin

(2012) D. Zamolodchikov et al.   BLOOD

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity

(2012) Emilia S. Olson et al.   Integrative Biology

Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease

(2012) Valerio Pisani et al.   Journal of Neuroinflammation

Thrombin Activity Associated with Neuronal Damage during Acute Focal Ischemia

(2012) B. Chen et al.   JOURNAL OF NEUROSCIENCE

Inflammation and neurovascular changes in amyotrophic lateral sclerosis

(2012) M.C. Evans et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Initial investigation of the blood-brain barrier in MS lesions at 7 tesla

(2012) María I Gaitán et al.   Multiple Sclerosis Journal

Turning point: Mark Lawrence

(2012) Alexandra Bell   NATURE

Microbleeds in dementia—singing a different ARIA

(2012) Philip Scheltens et al.   Nature Reviews Neurology

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Correlating structure and function during the evolution of fibrinogen-related domains

(2012) Russell F. Doolittle et al.   PROTEIN SCIENCE

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Evolution of the blood-brain barrier in newly forming multiple sclerosis lesions

(2011) María I. Gaitán et al.   ANNALS OF NEUROLOGY

Myelin Regeneration: A Recapitulation of Development?

(2011) Stephen P.J. Fancy et al.   Annual Review of Neuroscience

Molecular Mechanisms Affecting Fibrin Structure and Stability

(2011) Susan T. Lord   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification of VLDLR as a novel endothelial cell receptor for fibrin that modulates fibrin-dependent transendothelial migration of leukocytes

(2011) S. Yakovlev et al.   BLOOD

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke

(2011) Kim M. Baeten et al.   Developmental Neurobiology

Current concepts of blood-brain barrier development

(2011) Stefan Liebner et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis

(2011) Rebecca Craig-Schapiro et al.   PLoS One

Plasma Biomarkers of Brain Atrophy in Alzheimer's Disease

(2011) Madhav Thambisetty et al.   PLoS One

Fibrinogen as a key regulator of inflammation in disease

(2011) Dimitrios Davalos et al.   Seminars in Immunopathology

Tenascins and the Importance of Adhesion Modulation

(2011) R. Chiquet-Ehrismann et al.   Cold Spring Harbor Perspectives in Biology

Blood–Brain Barrier Pathophysiology in Traumatic Brain Injury

(2011) Adam Chodobski et al.   Translational Stroke Research

Fibrinogen Depleting Agent Batroxobin has a Beneficial Effect on Experimental Autoimmune Encephalomyelitis

(2010) Yang Yang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Primary Role of Fibrinogen-Related Proteins in Invertebrates Is Defense, Not Coagulation

(2010) Patrick C. Hanington et al.   Journal of Innate Immunity

Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-  after Vascular Damage

(2010) C. Schachtrup et al.   JOURNAL OF NEUROSCIENCE

Extrinsic regulation of pluripotent stem cells

(2010) Martin F. Pera et al.   NATURE

Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization

(2010) Carson K. Lam et al.   NATURE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

(2010) Dan Shlosberg et al.   Nature Reviews Neurology

Enoxaparin treatment administered at both early and late stages of amyloid β deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Aβ levels

(2010) Nienke M. Timmer et al.   NEUROBIOLOGY OF DISEASE

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Alzheimer's disease peptide  -amyloid interacts with fibrinogen and induces its oligomerization

(2010) H. J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMPs: From Bone to Body Morphogenetic Proteins

(2010) D. Obradovic Wagner et al.   Science Signaling

Relevance of Aβ 1-42 Intrahippocampal Injection as An Animal Model of Inflamed Alzheimers Disease Brain

(2008) James McLarnon et al.   Current Alzheimer Research

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

(2008) Jae K. Ryu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

EP-2104R: A Fibrin-Specific Gadolinium-Based MRI Contrast Agent for Detection of Thrombus

(2008) Kirsten Overoye-Chan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

(2008) May H. Han et al.   NATURE

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

The extracellular matrix affects axonal regeneration in peripheral neuropathies

(2008) S. C. Previtali et al.   NEUROLOGY

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Blood-brain barrier disruption in post-traumatic epilepsy

(2007) O Tomkins et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY