Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

Targeting the KRAS, p38α, and NF-κB in lung adenocarcinoma cancer cells: The effect of combining RNA interferences with a chemical inhibitor

(2019) Habib Zarredar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Human Testis Phosphoproteome Reveals Kinases as Potential Targets in Spermatogenesis and Testicular Cancer

(2019) Judit Castillo et al.   MOLECULAR & CELLULAR PROTEOMICS

Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models

(2019) Yves Depetter et al.   INTERNATIONAL JOURNAL OF CANCER

Design and molecular modeling of novel P38α MAPK inhibitors targeting breast cancer, synthesized from oxygen heterocyclic natural compounds

(2019) Omaima M. Abdelhafez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Genetic compensation triggered by mutant mRNA degradation

(2019) Mohamed A. El-Brolosy et al.   NATURE

2,4‑Di‑tert‑butylphenol, a potential HDAC6 inhibitor, induces senescence and mitotic catastrophe in human gastric adenocarcinoma AGS cells

(2018) Yeon Woo Song et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Estimation of clinical trial success rates and related parameters

(2018) Chi Heem Wong et al.   BIOSTATISTICS

MiR-199a/b-3p inhibits gastric cancer cell proliferation via down-regulating PAK4/MEK/ERK signaling pathway

(2018) Bin Zeng et al.   BMC CANCER

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

(2018) Begoña Cánovas et al.   CANCER CELL

Pim1 supports human colorectal cancer growth during glucose deprivation by enhancing the Warburg effect

(2018) Meng Zhang et al.   CANCER SCIENCE

Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer

(2018) Kaili Liu et al.   CANCER SCIENCE

The Emerging Picture of CDK11: Genetic, Functional and Medicinal Aspects

(2018) Nikolas Ferreira dos Santos Paparidis et al.   CURRENT MEDICINAL CHEMISTRY

PAC-1 and its derivative WF-210 Inhibit Angiogenesis by inhibiting VEGF/VEGFR pathway

(2018) Fangyang Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer

(2018) Jing Dong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia

(2018) Yusuke Tarumoto et al.   MOLECULAR CELL

Discovery of 2-(4-Substituted-piperidin/piperazine-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-quinazoline-2,4-diamines as PAK4 Inhibitors with Potent A549 Cell Proliferation, Migration, and Invasion Inhibition Activity

(2018) Tianxiao Wu et al.   MOLECULES

Kinase inhibitors: the road ahead

(2018) Fleur M. Ferguson et al.   NATURE REVIEWS DRUG DISCOVERY

PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis

(2018) Bin Zhao et al.   Cell Death & Disease

Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes

(2018) Jasper Edgar Neggers et al.   Nature Communications

MELK expression correlates with tumor mitotic activity but is not required for cancer growth

(2018) Christopher J Giuliano et al.   eLife

Regulation of Mammary Luminal Cell Fate and Tumorigenesis by p38α

(2018) Ivan del Barco Barrantes et al.   Stem Cell Reports

CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression

(2018) Xu-hong Fu et al.   ACTA PHARMACOLOGICA SINICA

p21-activated kinase 4 as a switch between caspase-8 apoptosis and NF-κB survival signals in response to TNF-α in hepatocarcinoma cells

(2018) Qing Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Kinase PIM1 promotes prostate cancer cell growth via c-Myc-RPS7-driven ribosomal stress

(2018) Changwen Zhang et al.   CARCINOGENESIS

The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction

(2018) Chen Ye et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Preclinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma

(2018) Renate De Smedt et al.   HAEMATOLOGICA

Antiproliferative potential of miR-33a in laryngeal cancer Hep-2 cells via targeting PIM1

(2018) Omer Faruk Karatas   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Genetic and transcriptional evolution alters cancer cell line drug response

(2018) Uri Ben-David et al.   NATURE

A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression

(2018) Jeroen van den Berg et al.   NUCLEIC ACIDS RESEARCH

Ricolinostat (ACY-1215) suppresses proliferation and promotes apoptosis in esophageal squamous cell carcinoma via miR-30d/PI3K/AKT/mTOR and ERK pathways

(2018) Jinlin Cao et al.   Cell Death & Disease

The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death

(2018) Maciej Kaliszczak et al.   BRITISH JOURNAL OF CANCER

Sulforaphane induces autophagy by inhibition of HDAC6-mediated PTEN activation in triple negative breast cancer cells

(2018) Fan Yang et al.   LIFE SCIENCES

Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer

(2018) Yong Wu et al.   OncoTargets and Therapy

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

(2018) James M. McFarland et al.   Nature Communications

Novel selective TOPK inhibitor SKLB-C05 inhibits colorectal carcinoma growth and metastasis

(2018) Tiantao Gao et al.   CANCER LETTERS

Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776

(2017) Xiuxiu Hou et al.   EXPERIMENTAL CELL RESEARCH

PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells

(2017) Amany Sayed Mawas et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

ADA-07 Suppresses Solar Ultraviolet–Induced Skin Carcinogenesis by Directly Inhibiting TOPK

(2017) Ge Gao et al.   MOLECULAR CANCER THERAPEUTICS

PIM-1 kinase inhibitor SMI-4a exerts antitumor effects in chronic myeloid leukemia cells by enhancing the activity of glycogen synthase kinase 3β

(2017) Rui-Fang Fan et al.   Molecular Medicine Reports

PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

(2017) Hezhe Lu et al.   NATURE

ARID1A-mutated ovarian cancers depend on HDAC6 activity

(2017) Benjamin G. Bitler et al.   NATURE CELL BIOLOGY

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

(2017) Robin M Meyers et al.   NATURE GENETICS

HDAC6 inhibition suppresses chondrosarcoma by restoring the expression of primary cilia

(2017) Wei Xiang et al.   ONCOLOGY REPORTS

Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4

(2017) Zhiheng Li et al.   ONCOLOGY REPORTS

p38MAPK family isoform p38α and activating transcription factor 2 are associated with the malignant phenotypes and poor prognosis of patients with ovarian adenocarcinoma

(2017) Wan-Juan Song et al.   PATHOLOGY RESEARCH AND PRACTICE

Inhibitors of cyclin-dependent kinases as cancer therapeutics

(2017) Steven R. Whittaker et al.   PHARMACOLOGY & THERAPEUTICS

Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis

(2017) Haiwei Mou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The target landscape of clinical kinase drugs

(2017) Susan Klaeger et al.   SCIENCE

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

(2017) Avadhut D. Joshi et al.   Oncotarget

Tumor p38MAPK signaling enhances breast carcinoma vascularization and growth by promoting expression and deposition of pro-tumorigenic factors

(2017) Michelle Limoge et al.   Oncotarget

Targeting the T-Lak cell originated protein kinase by OTS964 shrinks the size of power-law coded heterogeneous glioma stem cell populations

(2017) Michiya Sugimori et al.   Oncotarget

Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map

(2017) Ian Smith et al.   PLOS BIOLOGY

Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

(2017) William Putzbach et al.   eLife

CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials

(2017) Ann Lin et al.   eLife

PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migration

(2017) Helen King et al.   Scientific Reports

Overexpression of PBK/TOPK Contributes to Tumor Development and Poor Outcome of Esophageal Squamous Cell Carcinoma

(2016) TAKUMA OHASHI et al.   ANTICANCER RESEARCH

4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer

(2016) Carole Seidel et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis and biological evaluation of quinoline derivatives as potential anti-prostate cancer agents and Pim-1 kinase inhibitors

(2016) Kun Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of quinones as novel PIM1 kinase inhibitors

(2016) Richard L. Schroeder et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia

(2016) M. Bellon et al.   BLOOD

Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma

(2016) Takuma Ohashi et al.   BRITISH JOURNAL OF CANCER

HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma

(2016) Zhihao Wang et al.   CANCER LETTERS

MicroRNA-124-3p regulates cell proliferation, invasion, apoptosis, and bioenergetics by targeting PIM1 in astrocytoma

(2016) Danni Deng et al.   CANCER SCIENCE

T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer

(2016) Y. Ikeda et al.   CLINICAL CANCER RESEARCH

Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities

(2016) Howard S. Roth et al.   CURRENT MEDICINAL CHEMISTRY

Expression and function of PIM kinases in osteosarcoma

(2016) Shuai Mou et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells

(2016) Jiaqi Liu et al.   Journal of Translational Medicine

HDAC6 Deacetylates HMGN2 to Regulate Stat5a Activity and Breast Cancer Growth

(2016) T. R. Medler et al.   MOLECULAR CANCER RESEARCH

The Combination of Vemurafenib and Procaspase-3 Activation Is Synergistic in Mutant BRAF Melanomas

(2016) J. Peh et al.   MOLECULAR CANCER THERAPEUTICS

Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma

(2016) Amro Aboukameel et al.   MOLECULAR CANCER THERAPEUTICS

Essential role of HDAC6 in the regulation of PD-L1 in melanoma

(2016) M. Lienlaf et al.   Molecular Oncology

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes

(2016) Bastiaan Evers et al.   NATURE BIOTECHNOLOGY

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

(2016) Dai Horiuchi et al.   NATURE MEDICINE

PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

(2016) Fara Brasó-Maristany et al.   NATURE MEDICINE

Phase II and phase III failures: 2013–2015

(2016) Richard K. Harrison   NATURE REVIEWS DRUG DISCOVERY

HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma

(2016) ZHIHAO WANG et al.   ONCOLOGY REPORTS

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

(2016) Teru Hideshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIM kinases as therapeutic targets against advanced melanoma

(2016) Batool Shannan et al.   Oncotarget

Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon

(2016) Juanjuan Xiao et al.   Oncotarget

PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth

(2016) Olesia S. Vishchuk et al.   Oncotarget

Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells

(2016) Taigo Kato et al.   Oncotarget

Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase

(2016) Xinhua Song et al.   Oncotarget

Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase

(2016) Jianjun Yang et al.   Journal of Ginseng Research

Comparison of FDA Approved Kinase Targets to Clinical Trial Ones: Insights from Their System Profiles and Drug-Target Interaction Networks

(2016) Jingyu Xu et al.   Biomed Research International

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

(2016) Max A Horlbeck et al.   eLife

PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation

(2015) Xiaoyan Dou et al.   Cancer Cell International

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance

(2015) M. D. Gurden et al.   CANCER RESEARCH

A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer

(2015) J.-E. Kim et al.   CANCER RESEARCH

Dual Targeting of Protein Degradation Pathways with the Selective HDAC6 Inhibitor ACY-1215 and Bortezomib Is Synergistic in Lymphoma

(2015) J. E. Amengual et al.   CLINICAL CANCER RESEARCH

Targeting executioner procaspase-3 with the procaspase-activating compound B-PAC-1 induces apoptosis in multiple myeloma cells

(2015) Shadia Zaman et al.   EXPERIMENTAL HEMATOLOGY

PBK/TOPK expression correlates with mutant p53 and affects patients' prognosis and cell proliferation and viability in lung adenocarcinoma

(2015) Bin Lei et al.   HUMAN PATHOLOGY

Overexpression of PDZ-binding kinase confers malignant phenotype in prostate cancer via the regulation of E2F1

(2015) Jia-Hong Chen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

MiR-199a/b-3p suppresses migration and invasion of breast cancer cells by downregulating PAK4/MEK/ERK signaling pathway

(2015) Shou-Qing Li et al.   IUBMB LIFE

Targeting procaspase-3 with WF-208, a novel PAC-1 derivative, causes selective cancer cell apoptosis

(2015) Fangyang Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer

(2015) Zhuang Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clinical and biological significance of PIM1 kinase in osteosarcoma

(2015) Yunfei Liao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo

(2015) Mrinal Joel et al.   Molecular Cancer

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation

(2015) K.V. Woan et al.   Molecular Oncology

NBM-T-BBX-OS01, Semisynthesized from Osthole, Induced G1 Growth Arrest through HDAC6 Inhibition in Lung Cancer Cells

(2015) Jih-Tung Pai et al.   MOLECULES

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

(2015) Junwei Shi et al.   NATURE BIOTECHNOLOGY

PBK/TOPK mediates promyelocyte proliferation via Nrf2-regulated cell cycle progression and apoptosis

(2015) YUHONG LIU et al.   ONCOLOGY REPORTS

miR-433 inhibits oral squamous cell carcinoma (OSCC) cell growth and metastasis by targeting HDAC6

(2015) Xiao-chun Wang et al.   ORAL ONCOLOGY

Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells

(2015) Yi-Min Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aceroside VIII is a New Natural Selective HDAC6 Inhibitor that Synergistically Enhances the Anticancer Activity of HDAC Inhibitor in HT29 Cells

(2015) Hyun-Wook Ryu et al.   PLANTA MEDICA

Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling

(2015) Shun Li et al.   TUMOR BIOLOGY

T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia

(2015) Houda Alachkar et al.   Oncotarget

PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma

(2015) Carmen Oi-ning Leung et al.   Oncotarget

PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer

(2015) Yanjie Zhang et al.   EBioMedicine

Transcription Activator-Like Effector Nuclease (TALEN)-Mediated CLYBL Targeting Enables Enhanced Transgene Expression and One-Step Generation of Dual Reporter Human Induced Pluripotent Stem Cell (iPSC) and Neural Stem Cell (NSC) Lines

(2015) Trevor Cerbini et al.   PLoS One

Down-Regulation of Deacetylase HDAC6 Inhibits the Melanoma Cell Line A375.S2 Growth through ROS-Dependent Mitochondrial Pathway

(2015) Jun Bai et al.   PLoS One

2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity

(2015) Lei Wang et al.   PLoS One

p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway

(2015) Nikhil Tyagi et al.   Oncotarget

HDAC6 Deacetylates Ku70 and Regulates Ku70-Bax Binding in Neuroblastoma

(2015) Chitra Subramanian et al.   NEOPLASIA

Functional Role and Therapeutic Potential of the Pim-1 Kinase in Colon Carcinoma

(2015) Ulrike Weirauch et al.   NEOPLASIA

PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathways

(2014) Xueqiong Fu et al.   BIOSCIENCE REPORTS

Expression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cells

(2014) V. Patel et al.   BLOOD

Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival

(2014) Jalaj Gupta et al.   CANCER CELL

HDAC6 sustains growth stimulation by prolonging the activation of EGF receptor through the inhibition of rabaptin-5-mediated early endosome fusion in gastric cancer

(2014) Se Jin Park et al.   CANCER LETTERS

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

BRAF Inhibitor Resistance Mechanisms in Metastatic Melanoma: Spectrum and Clinical Impact

(2014) H. Rizos et al.   CLINICAL CANCER RESEARCH

Design, synthesis, and structure–activity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents

(2014) Junjie Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis

(2014) Manjola Balliu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma

(2014) Xin Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Azaindolylsulfonamides, with a More Selective Inhibitory Effect on Histone Deacetylase 6 Activity, Exhibit Antitumor Activity in Colorectal Cancer HCT116 Cells

(2014) Hsueh-Yun Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dual Small-Molecule Targeting of Procaspase-3 Dramatically Enhances Zymogen Activation and Anticancer Activity

(2014) Rachel C. Botham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PIM Kinase Inhibitor AZD1208 for Treatment of MYC-Driven Prostate Cancer

(2014) Austin N. Kirschner et al.   JNCI-Journal of the National Cancer Institute

A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts

(2014) Fangyang Wang et al.   Molecular Oncology

DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells

(2014) Yegor Smurnyy et al.   Nature Chemical Biology

Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival

(2014) Susann Herzog et al.   NEURO-ONCOLOGY

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

The Rational Design of Specific Peptide Inhibitor against p38α MAPK at Allosteric-Site: A Therapeutic Modality for HNSCC

(2014) Kamaldeep Gill et al.   PLoS One

TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis

(2014) Y. Matsuo et al.   Science Translational Medicine

MicroRNA-486-5p targeting PIM-1 suppresses cell proliferation in breast cancer cells

(2014) Guoqiang Zhang et al.   TUMOR BIOLOGY

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Effects of Down-regulation of HDAC6 Expression on Proliferation, Cell Cycling and Migration of Esophageal Squamous Cell Carcinoma Cells and Related Molecular Mechanisms

(2013) Ning Li et al.   Asian Pacific Journal of Cancer Prevention

A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth

(2013) M Kaliszczak et al.   BRITISH JOURNAL OF CANCER

HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth

(2013) S. A. Gradilone et al.   CANCER RESEARCH

T-LAK cell-originated protein kinase is essential for the proliferation of hepatocellular carcinoma SMMC-7721 cells

(2013) Fang Chen et al.   CELL BIOCHEMISTRY AND FUNCTION

Ins and Outs of Kinase DFG Motifs

(2013) Daniel K. Treiber et al.   CHEMISTRY & BIOLOGY

tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells

(2013) Sergio Valente et al.   ChemMedChem

HDAC6 promotes hepatocellular carcinoma progression by inhibiting P53 transcriptional activity

(2013) Gang Ding et al.   FEBS LETTERS

A microenvironment-mediated c-Myc/miR-548m/HDAC6 amplification loop in non-Hodgkin B cell lymphomas

(2013) Tint Lwin et al.   JOURNAL OF CLINICAL INVESTIGATION

HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS

(2013) M. H. Yang et al.   MOLECULAR CANCER RESEARCH

Characterization of LY2228820 Dimesylate, a Potent and Selective Inhibitor of p38 MAPK with Antitumor Activity

(2013) R. M. Campbell et al.   MOLECULAR CANCER THERAPEUTICS

A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis

(2013) Kantima Leelahavanichkul et al.   Molecular Oncology

Discovery of Hybrid Dual N-Acylhydrazone and Diaryl Urea Derivatives as Potent Antitumor Agents: Design, Synthesis and Cytotoxicity Evaluation

(2013) Xin Zhai et al.   MOLECULES

BLAST: a more efficient report with usability improvements

(2013) Grzegorz M. Boratyn et al.   NUCLEIC ACIDS RESEARCH

The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation

(2013) Mei-Jen Chuang et al.   PLoS One

Development of a histone deacetylase 6 inhibitor and its biological effects

(2013) J.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

The Pak4 protein kinase is required for oncogenic transformation of MDA-MB-231 breast cancer cells

(2013) L E Wong et al.   Oncogenesis

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

(2012) L. Santo et al.   BLOOD

p38 mitogen-activated protein kinase signaling, ERCC1 expression, and viability of lung cancer cells from never or light smoker patients

(2012) David Planchard et al.   CANCER

Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation

(2012) James W. Antoon et al.   CANCER BIOLOGY & THERAPY

Novel TOPK Inhibitor HI-TOPK-032 Effectively Suppresses Colon Cancer Growth

(2012) D. J. Kim et al.   CANCER RESEARCH

Killing cells by targeting mitosis

(2012) E Manchado et al.   CELL DEATH AND DIFFERENTIATION

Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth

(2012) Joel A. Bergman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Evolution of a Novel Type of Potent and Selective Proviral Integration Site in Moloney Murine Leukemia Virus Kinase 1 (PIM1) Inhibitor from a Screening-Hit Compound

(2012) Hirofumi Nakano et al.   JOURNAL OF MEDICINAL CHEMISTRY

HDAC6 as a target for antileukemic drugs in acute myeloid leukemia

(2012) Björn Hackanson et al.   LEUKEMIA RESEARCH

c-Myc and E2F1 drive PBK/TOPK expression in high-grade malignant lymphomas

(2012) Fang Hu et al.   LEUKEMIA RESEARCH

Knockdown of PAK4 or PAK1 Inhibits the Proliferation of Mutant KRAS Colon Cancer Cells Independently of RAF/MEK/ERK and PI3K/AKT Signaling

(2012) H. Tabusa et al.   MOLECULAR CANCER RESEARCH

Differential Effects of Procaspase-3 Activating Compounds in the Induction of Cancer Cell Death

(2012) Diana C. West et al.   MOLECULAR PHARMACEUTICS

Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer

(2012) Harald von Boehmer et al.   NATURE REVIEWS DRUG DISCOVERY

p21-Activated kinase 4 promotes prostate cancer progression through CREB

(2012) M-H Park et al.   ONCOGENE

Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells

(2012) Lei Wang et al.   PLoS One

Inhibition of Pim–1 attenuates the proliferation and migration in nasopharyngeal carcinoma cells

(2012) Wei Jie et al.   Asian Pacific Journal of Tropical Medicine

Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation

(2012) Anthony B. Mak et al.   Cell Reports

A Novel Class of Small Molecule Inhibitors of HDAC6

(2011) Elizabeth S. Inks et al.   ACS Chemical Biology

LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells

(2011) Jian Zhang et al.   CANCER LETTERS

The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells

(2011) D. Xu et al.   CARCINOGENESIS

Clinical and therapeutic relevance of PIM1 kinase in gastric cancer

(2011) Benedict Yan et al.   Gastric Cancer

Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells

(2011) Grace I. Aldana-Masangkay et al.   LEUKEMIA & LYMPHOMA

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes

(2011) Thomas Force et al.   NATURE REVIEWS DRUG DISCOVERY

The proto-oncogene Pim-1 is a target of miR-33a

(2011) M Thomas et al.   ONCOGENE

Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells

(2011) J Wang et al.   ONCOGENE

Mitosis as an anti-cancer target

(2011) A Janssen et al.   ONCOGENE

Histone Deacetylase 6 Regulates Estrogen Receptor α in Uterine Leiomyoma

(2011) Lin-Hung Wei et al.   Reproductive Sciences

Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237

(2010) Dominic A. Sloane et al.   ACS Chemical Biology

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

(2010) Carmen Blanco-Aparicio et al.   CANCER LETTERS

Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3-Activating Compound

(2010) Q. P. Peterson et al.   CANCER RESEARCH

p38α Is Required for Ovarian Cancer Cell Metabolism and Survival

(2010) Antonio Matrone et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs

(2010) Pamela W. Lucas et al.   INVESTIGATIONAL NEW DRUGS

Cell-permeable Carboxyl-terminal p27Kip1Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase

(2010) Daisuke Morishita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21

(2010) F Hu et al.   ONCOGENE

p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients

(2010) M. K. Y. Siu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

(2010) B. W. Murray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation

(2009) Jian Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Stable interference of EWS–FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target

(2009) D Herrero-Martín et al.   BRITISH JOURNAL OF CANCER

Inhibition of the p38 Kinase Suppresses the Proliferation of Human ER-Negative Breast Cancer Cells

(2009) L. Chen et al.   CANCER RESEARCH

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription

(2009) F Chiacchiera et al.   CELL DEATH AND DIFFERENTIATION

Pim-1 expression and monoclonal antibody targeting in human leukemia cell lines

(2009) Jie Li et al.   EXPERIMENTAL HEMATOLOGY

PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition

(2009) Quinn P. Peterson et al.   JOURNAL OF MOLECULAR BIOLOGY

HDAC6 Regulates Androgen Receptor Hypersensitivity and Nuclear Localization via Modulating Hsp90 Acetylation in Castration-Resistant Prostate Cancer

(2009) Junkui Ai et al.   MOLECULAR ENDOCRINOLOGY

Small-Molecule Activators of a Proenzyme

(2009) D. W. Wolan et al.   SCIENCE

The Cytoplasmic Deacetylase HDAC6 Is Required for Efficient Oncogenic Tumorigenesis

(2008) Y.-S. Lee et al.   CANCER RESEARCH

Molecular Basis of Drug Resistance in Aurora Kinases

(2008) Fiona Girdler et al.   CHEMISTRY & BIOLOGY

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

(2008) Chun Kim et al.   NATURE IMMUNOLOGY

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

(2008) A. C. Kimmelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA