NBM-T-BBX-OS01, Semisynthesized from Osthole, Induced G1 Growth Arrest through HDAC6 Inhibition in Lung Cancer Cells

Wild-type EGFR Is Stabilized by Direct Interaction with HSP90 in Cancer Cells and Tumors

(2015) Aarif Ahsan et al.   NEOPLASIA

Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells

(2014) Vinayak Khattar et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Induction of p21Waf1/Cip1 by Garcinol via Downregulation of p38-MAPK Signaling in p53-Independent H1299 Lung Cancer

(2014) Sheng-Yung Yu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats

(2013) Ying-Chen Yang et al.   Evidence-based Complementary and Alternative Medicine

The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial–mesenchymal transition of lens epithelial cells

(2013) X Chen et al.   Cell Death & Disease

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

(2012) L. Santo et al.   BLOOD

Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo

(2012) Tripti Singh et al.   Epigenetics

Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed

(2012) Berkley E Gryder et al.   Future Medicinal Chemistry

Chipping away at the lung cancer genome

(2012) William Pao et al.   NATURE MEDICINE

PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27Kip1

(2012) M. Perez-Luna et al.   NUCLEIC ACIDS RESEARCH

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

(2011) Mehdi Mollapour et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

(2011) D Li et al.   CELL DEATH AND DIFFERENTIATION

Epigenetics and chemoresistance in colorectal cancer: An opportunity for treatment tailoring and novel therapeutic strategies

(2011) Francesco Crea et al.   DRUG RESISTANCE UPDATES

Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin

(2011) David Kaluza et al.   EMBO JOURNAL

Molecular basis for the actions of Hsp90 inhibitors and cancer therapy

(2011) Hiroshi Yamaki et al.   JOURNAL OF ANTIBIOTICS

4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-κB activity

(2011) Ju Hoon Oh et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung

(2011) Yoshihiro Minamiya et al.   LUNG CANCER

The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyrosine kinase inhibitor

(2011) Naruyuki Kobayashi et al.   LUNG CANCER

CG0006, a novel histone deacetylase inhibitor, induces breast cancer cell death via histone-acetylation and chaperone-disrupting pathways independent of ER status

(2010) Hyun Mi Kim et al.   BREAST CANCER RESEARCH AND TREATMENT

The clinical development of histone deacetylase inhibitors as targeted anticancer drugs

(2010) Paul A Marks   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression

(2010) T. Yamaguchi et al.   GENES & DEVELOPMENT

Role of cell cycle regulators in lung carcinogenesis

(2010) Beatrice Eymin et al.   Cell Adhesion & Migration

E2F1 transcription is induced by genotoxic stress through ATM/ATR activation

(2009) Abel L. Carcagno et al.   IUBMB LIFE

Cutting Edge: Negative Regulation of Dendritic Cells through Acetylation of the Nonhistone Protein STAT-3

(2009) Yaping Sun et al.   JOURNAL OF IMMUNOLOGY

Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells

(2008) Kazuo Kamemura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors

(2008) Jung-Hyun Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Cytoplasmic Deacetylase HDAC6 Is Required for Efficient Oncogenic Tumorigenesis

(2008) Y.-S. Lee et al.   CANCER RESEARCH

Role of Acetylation and Extracellular Location of Heat Shock Protein 90  in Tumor Cell Invasion

(2008) Y. Yang et al.   CANCER RESEARCH

Inhibition of Hsp90 Down-regulates Mutant Epidermal Growth Factor Receptor (EGFR) Expression and Sensitizes EGFR Mutant Tumors to Paclitaxel

(2008) A. Sawai et al.   CANCER RESEARCH

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY