Targeting procaspase-3 with WF-208, a novel PAC-1 derivative, causes selective cancer cell apoptosis

A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts

(2014) Fangyang Wang et al.   Molecular Oncology

Synthesis and initial in vitro biological evaluation of two new zinc-chelating compounds: Comparison with TPEN and PAC-1

(2013) O. Alexander H. Åstrand et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Seed Oil ofBrucea javanicaInduces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways

(2012) Hong Zhang et al.   Evidence-based Complementary and Alternative Medicine

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Caspase Substrates and Cellular Remodeling

(2011) Emily D. Crawford et al.   Annual Review of Biochemistry

Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1)

(2011) Danny C. Hsu et al.   ACS Combinatorial Science

Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3-Activating Compound

(2010) Q. P. Peterson et al.   CANCER RESEARCH

Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs

(2010) Pamela W. Lucas et al.   INVESTIGATIONAL NEW DRUGS

Procaspase-activating compound 1 induces a caspase-3-dependent cell death in cerebellar granule neurons

(2010) Gulzeb Aziz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Procaspase-3 Activation as an Anti-Cancer Strategy: Structure−Activity Relationship of Procaspase-Activating Compound 1 (PAC-1) and Its Cellular Co-Localization with Caspase-3

(2009) Quinn P. Peterson et al.   JOURNAL OF MEDICINAL CHEMISTRY

PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition

(2009) Quinn P. Peterson et al.   JOURNAL OF MOLECULAR BIOLOGY

A novel small molecule with potent anticancer activity inhibits cell growth by modulating intracellular labile zinc homeostasis

(2009) M. Huesca et al.   MOLECULAR CANCER THERAPEUTICS

Survivin and Caspase-3 Expression in Breast Cancer: Correlation With Prognostic Parameters, Proliferation, Angiogenesis, and Outcome

(2009) Aziza Nassar et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis

(2008) P Makhov et al.   CELL DEATH AND DIFFERENTIATION

Targeting apoptosis: selected anticancer strategies

(2008) Shane Storey   NATURE REVIEWS DRUG DISCOVERY