Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes
Authors
Keywords
-
Journal
Nature Communications
Volume 9, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-01-31
DOI
10.1038/s41467-017-02349-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis
- (2017) Jonathan J. Ipsaro et al. PLoS One
- Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool
- (2017) Katherine F. Donovan et al. PLoS One
- Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma
- (2016) Amro Aboukameel et al. MOLECULAR CANCER THERAPEUTICS
- XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer
- (2016) Jimi Kim et al. NATURE
- Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells
- (2016) Josep V Forment et al. Nature Chemical Biology
- Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells
- (2016) Yunqing Ma et al. NATURE METHODS
- Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells
- (2016) Gaelen T Hess et al. NATURE METHODS
- High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
- (2015) Traver Hart et al. CELL
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- Identifying Drug-Target Selectivity of Small-Molecule CRM1/XPO1 Inhibitors by CRISPR/Cas9 Genome Editing
- (2015) Jasper E. Neggers et al. CHEMISTRY & BIOLOGY
- Know your target, know your molecule
- (2015) Mark E Bunnage et al. Nature Chemical Biology
- Functional genomics to uncover drug mechanism of action
- (2015) Sebastian M B Nijman Nature Chemical Biology
- Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line
- (2014) Patrick Essletzbichler et al. GENOME RESEARCH
- DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells
- (2014) Yegor Smurnyy et al. Nature Chemical Biology
- DrugTargetSeqR: a genomics- and CRISPR-Cas9–based method to analyze drug targets
- (2014) Corynn Kasap et al. Nature Chemical Biology
- Easy quantitative assessment of genome editing by sequence trace decomposition
- (2014) Eva K. Brinkman et al. NUCLEIC ACIDS RESEARCH
- In vitro Development of Chemotherapy and Targeted Therapy Drug-Resistant Cancer Cell Lines: A Practical Guide with Case Studies
- (2014) Martina McDermott et al. Frontiers in Oncology
- Next-Generation NAMPT Inhibitors Identified by Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens
- (2013) Christina J. Matheny et al. CHEMISTRY & BIOLOGY
- Target identification and mechanism of action in chemical biology and drug discovery
- (2013) Monica Schenone et al. Nature Chemical Biology
- A reversible gene trap collection empowers haploid genetics in human cells
- (2013) Tilmann Bürckstümmer et al. NATURE METHODS
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- (2013) Ophir Shalem et al. SCIENCE
- Genetic Screens in Human Cells Using the CRISPR-Cas9 System
- (2013) Tim Wang et al. SCIENCE
- Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia
- (2012) R. Lapalombella et al. BLOOD
- Using transcriptome sequencing to identify mechanisms of drug action and resistance
- (2012) Sarah A Wacker et al. Nature Chemical Biology
- MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
- (2012) Kivanç Birsoy et al. NATURE GENETICS
- UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages
- (2012) R. Greinert et al. NUCLEIC ACIDS RESEARCH
- Overview of theCCP4 suite and current developments
- (2011) Martyn D. Winn et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- XPB, a subunit of TFIIH, is a target of the natural product triptolide
- (2011) Denis V Titov et al. Nature Chemical Biology
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Nampt/PBEF/visfatin and cancer
- (2010) Tie-qiang Bi et al. CANCER BIOLOGY & THERAPY
- The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors
- (2009) M. Watson et al. MOLECULAR AND CELLULAR BIOLOGY
- Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: Structure–activity relationship and mechanism of action
- (2008) Tine Van Neck et al. BIOORGANIC & MEDICINAL CHEMISTRY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now