A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts

Seed Oil ofBrucea javanicaInduces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways

(2012) Hong Zhang et al.   Evidence-based Complementary and Alternative Medicine

Novel Polypyridyl chelators deplete cellular zinc and destabilize the X-linked inhibitor of apoptosis protein (XIAP) prior to induction of apoptosis in human prostate and breast cancer cells

(2012) Jian Zuo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Caspase Substrates and Cellular Remodeling

(2011) Emily D. Crawford et al.   Annual Review of Biochemistry

GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1

(2011) Lin Zheng et al.   CANCER LETTERS

Survivin and IAP proteins in cell-death mechanisms

(2010) Dario C. Altieri   BIOCHEMICAL JOURNAL

Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3-Activating Compound

(2010) Q. P. Peterson et al.   CANCER RESEARCH

X-linked Inhibitor of Apoptosis: A Chemoresistance Factor or a Hollow Promise

(2010) H. Kashkar   CLINICAL CANCER RESEARCH

Survivin mediates prostate cell protection by HIF-1α against zinc toxicity

(2010) Young-Joo Yun et al.   PROSTATE

Procaspase-activating compound 1 induces a caspase-3-dependent cell death in cerebellar granule neurons

(2010) Gulzeb Aziz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Clinical development of novel proteasome inhibitors for cancer treatment

(2009) Huanjie Yang et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Procaspase-3 Activation as an Anti-Cancer Strategy: Structure−Activity Relationship of Procaspase-Activating Compound 1 (PAC-1) and Its Cellular Co-Localization with Caspase-3

(2009) Quinn P. Peterson et al.   JOURNAL OF MEDICINAL CHEMISTRY

PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition

(2009) Quinn P. Peterson et al.   JOURNAL OF MOLECULAR BIOLOGY

Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis

(2008) P Makhov et al.   CELL DEATH AND DIFFERENTIATION

Targeting apoptosis: selected anticancer strategies

(2008) Shane Storey   NATURE REVIEWS DRUG DISCOVERY

Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants

(2008) Sarah E. James et al.   NEUROTOXICOLOGY