Comparison of FDA Approved Kinase Targets to Clinical Trial Ones: Insights from Their System Profiles and Drug-Target Interaction Networks

Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia

(2016) M. Bellon et al.   BLOOD

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape

(2016) S.-O. Lim et al.   CANCER RESEARCH

Small-molecule kinase inhibitors: an analysis of FDA-approved drugs

(2016) Peng Wu et al.   DRUG DISCOVERY TODAY

Identification of the inhibitory mechanism of FDA approved selective serotonin reuptake inhibitors: an insight from molecular dynamics simulation study

(2016) Weiwei Xue et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

New Frontiers in Druggability

(2015) Dima Kozakov et al.   JOURNAL OF MEDICINAL CHEMISTRY

The genomic landscape of response to EGFR blockade in colorectal cancer

(2015) Andrea Bertotti et al.   NATURE

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

KEGG as a reference resource for gene and protein annotation

(2015) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information

(2015) Hong Yang et al.   NUCLEIC ACIDS RESEARCH

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mutational profiling of kinases in glioblastoma

(2014) Fonnet E Bleeker et al.   BMC CANCER

Advances in kinase targeting: current clinical use and clinical trials

(2014) Mathias Rask-Andersen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Druggability of the enzymes of the non-mevalonate-pathway

(2013) Tiziana Masini et al.   DRUG DISCOVERY TODAY

Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations

(2012) Woody Han et al.   CANCER LETTERS

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

(2012) Sandra Misale et al.   NATURE

Emerging therapeutic targets in endometrial cancer

(2011) Konstantin J. Dedes et al.   Nature Reviews Clinical Oncology

Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery

(2011) F. Zhu et al.   NUCLEIC ACIDS RESEARCH

Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma

(2010) Brian I. Rini   CANCER

Biochemical network-based drug-target prediction

(2010) Edda Klipp et al.   CURRENT OPINION IN BIOTECHNOLOGY

Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery

(2010) Stéphanie Pérot et al.   DRUG DISCOVERY TODAY

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Database resources of the National Center for Biotechnology Information

(2010) E. W. Sayers et al.   NUCLEIC ACIDS RESEARCH

Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway

(2010) S Murayama-Hosokawa et al.   ONCOGENE

Binding-Site Assessment by Virtual Fragment Screening

(2010) Niu Huang et al.   PLoS One

In vivo target validation using gene invalidation, RNA interference and protein functional knockout models: it is the time to combine

(2009) Olivier Vidalin et al.   CURRENT OPINION IN PHARMACOLOGY

What Are Next Generation Innovative Therapeutic Targets? Clues from Genetic, Structural, Physicochemical, and Systems Profiles of Successful Targets

(2009) F. Zhu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Kinase mutations in human disease: interpreting genotype–phenotype relationships

(2009) Piya Lahiry et al.   NATURE REVIEWS GENETICS

Update of TTD: Therapeutic Target Database

(2009) Feng Zhu et al.   NUCLEIC ACIDS RESEARCH

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

TissueDistributionDBs: a repository of organism-specific tissue-distribution profiles

(2009) Sunitha Kogenaru et al.   THEORETICAL CHEMISTRY ACCOUNTS

Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints

(2008) D Llobet et al.   JOURNAL OF CLINICAL PATHOLOGY

NCBI BLAST: a better web interface

(2008) M. Johnson et al.   NUCLEIC ACIDS RESEARCH

Quantitative systems-level determinants of human genes targeted by successful drugs

(2007) L. Yao et al.   GENOME RESEARCH