Discovery of 2-(4-Substituted-piperidin/piperazine-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-quinazoline-2,4-diamines as PAK4 Inhibitors with Potent A549 Cell Proliferation, Migration, and Invasion Inhibition Activity

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

(2016) Joachim Rudolph et al.   JOURNAL OF MEDICINAL CHEMISTRY

Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer

(2016) Yang-Guang Shao   WORLD JOURNAL OF GASTROENTEROLOGY

Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4

(2015) Dan Jin et al.   BIOCHEMICAL JOURNAL

Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists

(2015) Nam-Chul Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitors

(2015) Shuai Song et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

P21-Activated Kinase 4 (PAK4) Inhibitors as Potential Cancer Therapy

(2014) Ahmed F. Abdel-Magid   ACS Medicinal Chemistry Letters

Development of p21 Activated Kinase-Targeted Multikinase Inhibitors That Inhibit Thyroid Cancer Cell Migration

(2013) Yihui Ma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Group I and II mammalian PAKs have different modes of activation by Cdc42

(2012) Yohendran Baskaran et al.   EMBO REPORTS

LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells

(2011) Jian Zhang et al.   CANCER LETTERS

The emerging importance of group II PAKs

(2010) Claire M. Wells et al.   BIOCHEMICAL JOURNAL

Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy

(2010) Zhao-Sen Zeng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rho GTPases in cancer cell biology

(2008) Francisco M. Vega et al.   FEBS LETTERS

Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes

(2008) Alexander V. Statsuk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY