tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells

Molecular Pathways: The Complexity of the Epigenome in Cancer and Recent Clinical Advances

(2012) M. Conte et al.   CLINICAL CANCER RESEARCH

A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly

(2012) Chunfeng Li et al.   FEBS Journal

Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4 (HDAC4)

(2012) I. Palmisano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A focus on the preclinical development and clinical status of the histone deacetylase inhibitor, romidepsin (depsipeptide, Istodax®)

(2012) Simon J Harrison et al.   Epigenomics

Pharmacological inhibition of HDAC6 attenuates endothelial barrier dysfunction induced by thrombin

(2011) Shigeki Saito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel Cinnamyl Hydroxyamides and 2-Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity

(2011) Sergio Valente et al.   ChemMedChem

CPTH6, a Thiazole Derivative, Induces Histone Hypoacetylation and Apoptosis in Human Leukemia Cells

(2011) D. Trisciuoglio et al.   CLINICAL CANCER RESEARCH

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9

(2011) Olivia Lenoir et al.   DIABETES

Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells

(2011) Meli   INTERNATIONAL JOURNAL OF ONCOLOGY

Discovery, Synthesis, and Pharmacological Evaluation of Spiropiperidine Hydroxamic Acid Based Derivatives as Structurally Novel Histone Deacetylase (HDAC) Inhibitors

(2011) Mario Varasi et al.   JOURNAL OF MEDICINAL CHEMISTRY

HDAC6 α-tubulin deacetylase: A potential therapeutic target in neurodegenerative diseases

(2011) Guoyi Li et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Synthesis and Biological Characterization of Amidopropenyl Hydroxamates as HDAC Inhibitors

(2010) Florian Thaler et al.   ChemMedChem

Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity

(2010) Luciana Auzzas et al.   JOURNAL OF MEDICINAL CHEMISTRY

HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation

(2010) Angela Nebbioso et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

(2010) Kyle V. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Small-molecule chromatin-modifying agents: therapeutic applications

(2010) Antonello Mai   Epigenomics

Pyrrole-Based Hydroxamates and 2-Aminoanilides: Histone Deacetylase Inhibition and Cellular Activities

(2009) Sergio Valente et al.   ChemMedChem

Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC–MEF2 complexes

(2009) Angela Nebbioso et al.   EMBO REPORTS

Synthesis and Biological Evaluation ofN-Hydroxyphenylacrylamides andN-Hydroxypyridin-2-ylacrylamides as Novel Histone Deacetylase Inhibitors

(2009) Florian Thaler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expression of Hypoxia-Inducible Factor-1α, Histone Deacetylase 1, and Metastasis-Associated Protein 1 in Pancreatic Carcinoma

(2009) Kotaro Miyake et al.   PANCREAS

HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2

(2008) Annamaria Scognamiglio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: Histone deacetylase inhibition and in-cell activities

(2008) Antonello Mai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer

(2008) Florian R Fritzsche et al.   BMC CANCER

Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy

(2008) W Weichert et al.   BRITISH JOURNAL OF CANCER

HDAC expression and clinical prognosis in human malignancies

(2008) Wilko Weichert   CANCER LETTERS

Class I Histone Deacetylase Expression Has Independent Prognostic Impact in Human Colorectal Cancer: Specific Role of Class I Histone Deacetylases In vitro and In vivo

(2008) W. Weichert et al.   CLINICAL CANCER RESEARCH

New pyrrole-based histone deacetylase inhibitors: Binding mode, enzyme- and cell-based investigations

(2008) Antonello Mai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

(2008) Anja Schuetz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6

(2008) Alan P. Kozikowski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Specific Activity of Class II Histone Deacetylases in Human Breast Cancer Cells

(2008) V. Duong et al.   MOLECULAR CANCER RESEARCH

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone deacetylase 2 expression predicts poorer prognosis in oral cancer patients

(2008) Hao-Hueng Chang et al.   ORAL ONCOLOGY

Nitric Oxide Modulates Chromatin Folding in Human Endothelial Cells via Protein Phosphatase 2A Activation and Class II Histone Deacetylases Nuclear Shuttling

(2007) Barbara Illi et al.   CIRCULATION RESEARCH