Expression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cells

A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts

(2014) Fangyang Wang et al.   Molecular Oncology

Impact of bone marrow stromal cells on Bcl-2 family members in chronic lymphocytic leukemia

(2013) Viralkumar Patel et al.   LEUKEMIA & LYMPHOMA

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy

(2013) C. Putinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tumor microenvironment is a dominant force in multidrug resistance

(2012) Ana Luísa Correia et al.   DRUG RESISTANCE UPDATES

Mechanism of zinc-mediated inhibition of caspase-9

(2012) Kristen L. Huber et al.   PROTEIN SCIENCE

SnapShot: Caspases

(2011) Guy S. Salvesen et al.   CELL

Inhibitors of Apoptosis Proteins (IAPs) as Potential Molecular Targets for Therapy of Hematological Malignancies

(2011) P. Smolewski et al.   CURRENT MOLECULAR MEDICINE

Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1)

(2011) Danny C. Hsu et al.   ACS Combinatorial Science

Discovery and Canine Preclinical Assessment of a Nontoxic Procaspase-3-Activating Compound

(2010) Q. P. Peterson et al.   CANCER RESEARCH

Programmed cell death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency

(2010) S. J. MARTIN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia

(2010) Olga Grzybowska-Izydorczyk et al.   EUROPEAN JOURNAL OF CANCER

Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs

(2010) Pamela W. Lucas et al.   INVESTIGATIONAL NEW DRUGS

Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

(2010) Federica Cossu et al.   PROTEIN SCIENCE

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy

(2009) Pierfausto Seneci et al.   BIOORGANIC & MEDICINAL CHEMISTRY

PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition

(2009) Quinn P. Peterson et al.   JOURNAL OF MOLECULAR BIOLOGY

c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches

(2008) D. Y. H. Hallaert et al.   BLOOD

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

(2008) M. Vogler et al.   BLOOD

AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance

(2008) K. Balakrishnan et al.   BLOOD

Inhibitor of apoptosis proteins in hematological malignancies

(2008) S Fulda   LEUKEMIA