CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials
Authors
Keywords
-
Journal
eLife
Volume 6, Issue -, Pages -
Publisher
eLife Sciences Organisation, Ltd.
Online
2017-03-24
DOI
10.7554/elife.24179
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- MELK is an oncogenic kinase essential for early hepatocellular carcinoma recurrence
- (2016) Hongping Xia et al. CANCER LETTERS
- Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance
- (2016) Richard Marcotte et al. CELL
- Maternal Embryonic Leucine Zipper Kinase (MELK) as a Novel Mediator and Biomarker of Radioresistance in Human Breast Cancer
- (2016) C. Speers et al. CLINICAL CANCER RESEARCH
- Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight
- (2016) B. Barry Touré et al. JOURNAL OF MEDICINAL CHEMISTRY
- Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting
- (2016) A. J. Aguirre et al. Cancer Discovery
- Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
- (2016) James Campbell et al. Cell Reports
- A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
- (2016) Konstantinos Tzelepis et al. Cell Reports
- OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases
- (2016) Wenbin Ji et al. PLoS One
- MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells
- (2015) L. Beke et al. BIOSCIENCE REPORTS
- High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
- (2015) Traver Hart et al. CELL
- Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR
- (2015) Michael Boettcher et al. MOLECULAR CELL
- Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
- (2015) Junwei Shi et al. NATURE BIOTECHNOLOGY
- Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer
- (2015) Suyoun Chung et al. Oncotarget
- Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia
- (2015) Houda Alachkar et al. Oncotarget
- The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor
- (2014) Yong-Soon Cho et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway
- (2014) Tao Du et al. Molecular Cancer
- Measuring error rates in genomic perturbation screens: gold standards for human functional genomics
- (2014) T. Hart et al. Molecular Systems Biology
- RNAi screening comes of age: improved techniques and complementary approaches
- (2014) Stephanie E. Mohr et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Easy quantitative assessment of genome editing by sequence trace decomposition
- (2014) Eva K. Brinkman et al. NUCLEIC ACIDS RESEARCH
- Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
- (2014) Christopher N. Johnson et al. ACS Medicinal Chemistry Letters
- Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase
- (2014) Christopher N. Johnson et al. ACS Medicinal Chemistry Letters
- MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells
- (2014) Yubao Wang et al. eLife
- Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
- (2014) Glenn S Cowley et al. Scientific Data
- A Transcriptional and Metabolic Signature of Primary Aneuploidy Is Present in Chromosomally Unstable Cancer Cells and Informs Clinical Prognosis
- (2013) J. M. Sheltzer CANCER RESEARCH
- Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells
- (2013) Cenk Kig et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Basis for the Regulation of Maternal Embryonic Leucine Zipper Kinase
- (2013) Lu-Sha Cao et al. PLoS One
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- (2013) Ophir Shalem et al. SCIENCE
- Tumor-Specific Activation of the C-JUN/MELK Pathway Regulates Glioma Stem Cell Growth in a p53-Dependent Manner
- (2013) Chunyu Gu et al. STEM CELLS
- The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer
- (2012) Ruprecht Kuner et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response
- (2012) Britt Adamson et al. NATURE CELL BIOLOGY
- A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens
- (2012) Frederic D Sigoillot et al. NATURE METHODS
- Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression
- (2011) Seungho Choi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Subcellular Fate and Off-Target Effects of siRNA, shRNA, and miRNA
- (2011) Saurabh Singh et al. PHARMACEUTICAL RESEARCH
- Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
- (2011) Richard Marcotte et al. Cancer Discovery
- Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo
- (2010) L. W. Hebbard et al. CANCER RESEARCH
- Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit
- (2010) Caroline Badouel et al. EXPERIMENTAL CELL RESEARCH
- Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists
- (2010) Sunil Badve et al. MODERN PATHOLOGY
- Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
- (2009) Ji Luo et al. CELL
- Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs
- (2009) Nadja C. Hübner et al. CHROMOSOMA
- Murine Protein Serine/Threonine Kinase 38 Activates Apoptosis Signal-regulating Kinase 1 via Thr838Phosphorylation
- (2008) Haiyoung Jung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Basal-Like Breast Cancer: A Critical Review
- (2008) Emad A. Rakha et al. JOURNAL OF CLINICAL ONCOLOGY
- Profiling Essential Genes in Human Mammary Cells by Multiplex RNAi Screening
- (2008) J. M. Silva et al. SCIENCE
- Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells
- (2007) Ichiro Nakano et al. JOURNAL OF NEUROSCIENCE RESEARCH
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started