PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas
Authors
Keywords
-
Journal
NATURE
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2017-09-27
DOI
10.1038/nature24040
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors
- (2016) Gao Zhang et al. JOURNAL OF CLINICAL INVESTIGATION
- Tunable-Combinatorial Mechanisms of Acquired Resistance Limit the Efficacy of BRAF/MEK Cotargeting but Result in Melanoma Drug Addiction
- (2015) Gatien Moriceau et al. CANCER CELL
- Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance
- (2015) Willy Hugo et al. CELL
- Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies
- (2015) C. Krepler et al. CLINICAL CANCER RESEARCH
- WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors
- (2014) Jamie N. Anastas et al. JOURNAL OF CLINICAL INVESTIGATION
- eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies
- (2014) Lise Boussemart et al. NATURE
- Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma
- (2014) Georgina V. Long et al. NEW ENGLAND JOURNAL OF MEDICINE
- Combined Vemurafenib and Cobimetinib in BRAF-Mutated Melanoma
- (2014) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma
- (2014) Georgina V. Long et al. Nature Communications
- GSVA: gene set variation analysis for microarray and RNA-Seq data
- (2013) Sonja Hänzelmann et al. BMC BIOINFORMATICS
- Pak1 Kinase Links ErbB2 to -Catenin in Transformation of Breast Epithelial Cells
- (2013) L. E. Arias-Romero et al. CANCER RESEARCH
- JNK regulates compliance-induced adherens junctions formation in epithelial cells and tissues
- (2013) H. You et al. JOURNAL OF CELL SCIENCE
- P21-Activated Kinase 1 (PAK1) as a Therapeutic Target in BRAF Wild-Type Melanoma
- (2013) Christy C. Ong et al. JNCI-Journal of the National Cancer Institute
- A melanocyte lineage program confers resistance to MAP kinase pathway inhibition
- (2013) Cory M. Johannessen et al. NATURE
- Challenging resistance mechanisms to therapies for metastatic melanoma
- (2013) Lucio Tentori et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
- (2013) H. Shi et al. Cancer Discovery
- MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition
- (2013) N. Wagle et al. Cancer Discovery
- The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma
- (2013) E. M. Van Allen et al. Cancer Discovery
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K
- (2010) Jessie Villanueva et al. CANCER CELL
- α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation
- (2010) Haitao Ji et al. JOURNAL OF NEURO-ONCOLOGY
- Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
- (2010) Ramin Nazarian et al. NATURE
- Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth
- (2010) B. W. Murray et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
- (2009) David A. Barbie et al. NATURE
- Pak1 and Pak2 Mediate Tumor Cell Invasion through Distinct Signaling Mechanisms
- (2008) S. J. Coniglio et al. MOLECULAR AND CELLULAR BIOLOGY
- Scaffolding function of PAK in the PDK1–Akt pathway
- (2008) Maiko Higuchi et al. NATURE CELL BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search