- Home
- Publications
- Publication Search
- Publication Details
Title
Potential Applications of NRF2 Inhibitors in Cancer Therapy
Authors
Keywords
-
Journal
Oxidative Medicine and Cellular Longevity
Volume 2019, Issue -, Pages 1-34
Publisher
Hindawi Limited
Online
2019-04-12
DOI
10.1155/2019/8592348
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance
- (2018) James H. Matthews et al. ACS Chemical Biology
- Small-Molecule Screening for Genetic Diseases
- (2018) Sarine Markossian et al. Annual Review of Genomics and Human Genetics
- Suppression of Nrf2 confers chemosensitizing effect through enhanced oxidant-mediated mitochondrial dysfunction
- (2018) Vachirapong Sompakdee et al. BIOMEDICINE & PHARMACOTHERAPY
- Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities
- (2018) Byung-Jin Jung et al. Biomolecules & Therapeutics
- Diosmetin Alleviates Lipopolysaccharide-Induced Acute Lung Injury through Activating the Nrf2 Pathway and Inhibiting the NLRP3 Inflammasome
- (2018) Qinmei Liu et al. Biomolecules & Therapeutics
- Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells
- (2018) Yuko Murakami et al. BMC CANCER
- NRF2 and the Hallmarks of Cancer
- (2018) Montserrat Rojo de la Vega et al. CANCER CELL
- High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma
- (2018) Yu Sun et al. CANCER LETTERS
- Nrf-2 transcriptionally activates P21 Cip/WAF1 and promotes A549 cell survival against oxidative stress induced by H 2 O 2
- (2018) Samarjit Jana et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Clinical and Pathological Characteristics ofKEAP1- andNFE2L2-Mutated Non–Small Cell Lung Carcinoma (NSCLC)
- (2018) Rieke Frank et al. CLINICAL CANCER RESEARCH
- Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation
- (2018) Anil Kumar et al. DIABETES
- Resistance to gefitinib and cross-resistance to irreversible EGFR-TKIs mediated by disruption of the Keap1-Nrf2 pathway in human lung cancer cells
- (2018) Seong-Hee Park et al. FASEB JOURNAL
- 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses drug resistance by decreasing glutathione synthesis and drug efflux in BEL-7402/5-FU cells
- (2018) Xing Wei et al. FOOD AND CHEMICAL TOXICOLOGY
- Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation
- (2018) Alyssa Walker et al. FREE RADICAL BIOLOGY AND MEDICINE
- Nrf2 protects against acute lung injury and inflammation by modulating TLR4 and Akt signaling
- (2018) Jia Yan et al. FREE RADICAL BIOLOGY AND MEDICINE
- Sulfiredoxin-1 enhances cardiac progenitor cell survival against oxidative stress via the upregulation of the ERK/NRF2 signal pathway
- (2018) Xiuchun Li et al. FREE RADICAL BIOLOGY AND MEDICINE
- Suppression of NRF2/ARE by convallatoxin sensitizes A549 cells to 5-FU-mediated apoptosis
- (2018) June Lee et al. FREE RADICAL RESEARCH
- Impact of Nrf2 on tumour growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo
- (2018) Jiajia Shao et al. FREE RADICAL RESEARCH
- Oncogenic mutations in KEAP1 disturbing inhibitory Nrf2-Keap1 interaction: Activation of antioxidative pathway in papillary thyroid carcinoma
- (2018) Debora Lucia Seguro Danilovic et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- NRF2 facilitates breast cancer cell growth via HIF1ɑ-mediated metabolic reprogramming
- (2018) Hong-Sheng Zhang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The Crosstalk between Nrf2 and Inflammasomes
- (2018) Paulina Hennig et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metformin Induces Apoptosis and Alters Cellular Responses to Oxidative Stress in Ht29 Colon Cancer Cells: Preliminary Findings
- (2018) Paola Sena et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Repurposing of the CDK inhibitor PHA-767491 as a NRF2 inhibitor drug candidate for cancer therapy via redox modulation
- (2018) Hsiu-Yu Liu et al. INVESTIGATIONAL NEW DRUGS
- Nrf2 promotes oesophageal cancer cell proliferation via metabolic reprogramming and detoxification of reactive oxygen species
- (2018) Yuki Kitano et al. JOURNAL OF PATHOLOGY
- Isoniazid induces apoptosis: Role of oxidative stress and inhibition of nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)
- (2018) Ajeet Kumar Verma et al. LIFE SCIENCES
- Activation of the KEAP1‑NRF2‑ARE signaling pathway reduces oxidative stress in Hep2 cells
- (2018) Changjiang Li et al. Molecular Medicine Reports
- GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells
- (2018) Patricia Dauer et al. Molecular Oncology
- Sulforaphane Attenuated the Pro-Inflammatory State Induced by Hydrogen Peroxide in SH-SY5Y Cells Through the Nrf2/HO-1 Signaling Pathway
- (2018) Marcos Roberto de Oliveira et al. NEUROTOXICITY RESEARCH
- Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism
- (2018) Mingzhu Bai et al. ONCOGENE
- MiR-148b functions as a tumor suppressor by targeting endoplasmic reticulum metallo protease 1 in human endometrial cancer cells
- (2018) Jinfeng Qu et al. ONCOLOGY RESEARCH
- Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs
- (2018) F. P. Fabrizio et al. Oxidative Medicine and Cellular Longevity
- Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway
- (2018) Yukai Xiang et al. Oxidative Medicine and Cellular Longevity
- UVA Irradiation Enhances Brusatol-Mediated Inhibition of Melanoma Growth by Downregulation of the Nrf2-Mediated Antioxidant Response
- (2018) Mei Wang et al. Oxidative Medicine and Cellular Longevity
- Inhibition of PDGFR by CP-673451 induces apoptosis and increases cisplatin cytotoxicity in NSCLC cells via inhibiting the Nrf2-mediated defense mechanism
- (2018) Yang Yang et al. TOXICOLOGY LETTERS
- ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells
- (2018) Ching-Wen Chang et al. Cell Death & Disease
- Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway
- (2018) Ying Lu et al. Cell Death & Disease
- Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway
- (2018) Juan Wang et al. Drug Design Development and Therapy
- The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer
- (2018) Jonathan P. Evans et al. Oncotarget
- Oxidative stress via inhibition of the mitochondrial electron transport and Nrf-2-mediated anti-oxidative response regulate the cytotoxic activity of plumbagin
- (2018) Arvinder Kapur et al. Scientific Reports
- High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance
- (2018) In-geun Ryoo et al. Redox Biology
- Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer
- (2018) Yoshinobu Ichimura et al. Frontiers in Oncology
- Nrf2 activation attenuates the early suppression of mitochondrial respiration due to the α-synuclein overexpression
- (2018) Mu-Hui Fu et al. Biomedical Journal
- Novel Neohesperidin Dihydrochalcone Analogue Inhibits Adipogenic Differentiation of Human Adipose-Derived Stem Cells through the Nrf2 Pathway
- (2018) Ga Han et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling
- (2018) Donghyeok Kim et al. Cell Death & Disease
- A catalogue of somatic NRF2 gain-of-function mutations in cancer
- (2018) Michael John Kerins et al. Scientific Reports
- Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells
- (2018) Hitoshi Endo et al. Scientific Reports
- Activation of Nrf2/HO-1 Pathway by Nardochinoid C Inhibits Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages
- (2018) Jin-Fang Luo et al. Frontiers in Pharmacology
- Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells
- (2017) Mario Negrette-Guzmán et al. FOOD AND CHEMICAL TOXICOLOGY
- Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation
- (2017) Kouhei Tsuchida et al. FREE RADICAL BIOLOGY AND MEDICINE
- Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells
- (2017) Huang-Hui Chen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes
- (2017) Nazir M. Khan et al. FREE RADICAL BIOLOGY AND MEDICINE
- Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling
- (2017) Saowanee Jeayeng et al. FREE RADICAL BIOLOGY AND MEDICINE
- Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas
- (2017) De-Chen Lin et al. GUT
- Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans
- (2017) Genki Hayashi et al. HUMAN MOLECULAR GENETICS
- Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway
- (2017) Chenxiao Yu et al. International Journal of Biological Sciences
- The Wnt inhibitor LGK-974 enhances radiosensitivity of HepG2 cells by modulating Nrf2 signaling
- (2017) Dan Tian et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Phosphorylation of tyrosine 568 controls nuclear export of Nrf2.
- (2017) Abhinav K. Jain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress
- (2017) Takafumi Suzuki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway
- (2017) Karen Bernard et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2
- (2017) Xiaoyan Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy
- (2017) Iris C. Salaroglio et al. Molecular Cancer
- miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1
- (2017) Burak Akdemir et al. MOLECULAR CANCER RESEARCH
- Brusatol overcomes chemoresistance through inhibition of protein translation
- (2017) Bryan Harder et al. MOLECULAR CARCINOGENESIS
- ABCF2 , an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells
- (2017) Lingjie Bao et al. MOLECULAR CARCINOGENESIS
- CDCA4, a downstream gene of the Nrf2 signaling pathway, regulates cell proliferation and apoptosis in the MCF‑7/ADM human breast cancer cell line
- (2017) Yuju Xu et al. Molecular Medicine Reports
- Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
- (2017) Rodrigo Romero et al. NATURE MEDICINE
- MicroRNA-144 modulates oxidative stress tolerance in SH-SY5Y cells by regulating nuclear factor erythroid 2-related factor 2-glutathione axis
- (2017) Chunlei Zhou et al. NEUROSCIENCE LETTERS
- A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer
- (2017) E-J Choi et al. ONCOGENE
- Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway
- (2017) Eun Hye Kim et al. Oxidative Medicine and Cellular Longevity
- NRF2 Regulates HER1 Signaling Pathway to Modulate the Sensitivity of Ovarian Cancer Cells to Lapatinib and Erlotinib
- (2017) Ibrahim H. Kankia et al. Oxidative Medicine and Cellular Longevity
- The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment
- (2017) Violetta Krajka-Kuźniak et al. Pharmacological Reports
- Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
- (2017) Annika S. Axelsson et al. Science Translational Medicine
- MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells
- (2017) Chengzhi Chen et al. TOXICOLOGY LETTERS
- Role of Nrf2 signaling pathway in the radiation tolerance of patients with head and neck squamous cell carcinoma: an in vivo and in vitro study
- (2017) Tao Wang et al. OncoTargets and Therapy
- Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop
- (2017) Yang Wang et al. Cell Death & Disease
- Nrf2 induces cisplatin resistance via suppressing the iron export related gene SLC40A1 in ovarian cancer cells
- (2017) Jianfa Wu et al. Oncotarget
- NFE2L2/NRF2 silencing-inducible miR-206 targets c-MET/EGFR and suppresses BCRP/ABCG2 in cancer cells
- (2017) Bo-Hyun Choi et al. Oncotarget
- ROS-independent Nrf2 activation in prostate cancer
- (2017) Ilaria Bellezza et al. Oncotarget
- Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma
- (2017) Federico Pio Fabrizio et al. Oncotarget
- A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib
- (2017) Nancy D. Ebelt et al. Oncotarget
- Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation
- (2017) Xuefen Xu et al. Scientific Reports
- Apigenin in cancer therapy: anti-cancer effects and mechanisms of action
- (2017) Xiaohui Yan et al. Cell and Bioscience
- KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer
- (2017) Elsa B Krall et al. eLife
- Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
- (2017) Volkan I Sayin et al. eLife
- Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
- (2017) Z Fan et al. Oncogenesis
- RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems
- (2017) Daiha Shin et al. Redox Biology
- Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics
- (2017) J. Javier Hernandez et al. Frontiers in Oncology
- Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2
- (2017) Sreeja Karathedath et al. PLoS One
- Transcription factors NRF2 and HSF1 have opposing functions in autophagy
- (2017) Sharadha Dayalan Naidu et al. Scientific Reports
- Comprehensive genomic analysis of Oesophageal Squamous Cell Carcinoma reveals clinical relevance
- (2017) Peina Du et al. Scientific Reports
- The Roles of NRF2 in Modulating Cellular Iron Homeostasis
- (2017) Michael John Kerins et al. ANTIOXIDANTS & REDOX SIGNALING
- Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors
- (2016) Anju Singh et al. ACS Chemical Biology
- Inhibition of heme oxygenase-1 enhances the chemosensitivity of laryngeal squamous cell cancer Hep-2 cells to cisplatin
- (2016) Xin Lv et al. APOPTOSIS
- Targeting Nrf2 with wogonin overcomes cisplatin resistance in head and neck cancer
- (2016) Eun Hye Kim et al. APOPTOSIS
- Involvement of NRF2 Signaling in Doxorubicin Resistance of Cancer Stem Cell-Enriched Colonospheres
- (2016) In-geun Ryoo et al. Biomolecules & Therapeutics
- Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity
- (2016) Daisuke Yasuda et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Berberine reverses lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS
- (2016) Ruohan Zhang et al. CANCER BIOLOGY & THERAPY
- p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells
- (2016) Atsushi Umemura et al. CANCER CELL
- Downregulation of Nrf2 by the combination of TRAIL and Valproic acid induces apoptotic cell death of TRAIL-resistant papillary thyroid cancer cells via suppression of Bcl-xL
- (2016) Hyun-Young Cha et al. CANCER LETTERS
- Dehydroepiandrosterone triggers autophagic cell death in human hepatoma cell line HepG2 via JNK-mediated p62/SQSTM1 expression
- (2016) Rolando Vegliante et al. CARCINOGENESIS
- Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets
- (2016) N. Rekhtman et al. CLINICAL CANCER RESEARCH
- MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer
- (2016) B. Zhang et al. CURRENT MOLECULAR MEDICINE
- Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters
- (2016) Xupeng Bai et al. DRUG METABOLISM REVIEWS
- Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation
- (2016) Kay L.H. Wu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer
- (2016) Yijun Tian et al. Journal of Hematology & Oncology
- Accumulation of phosphorylated p62 is associated with NF-E2-related factor 2 activation in hepatocellular carcinoma
- (2016) Takayuki Shimizu et al. Journal of Hepato-Biliary-Pancreatic Sciences
- Oxidative stress and lipotoxicity
- (2016) Amy K. Hauck et al. JOURNAL OF LIPID RESEARCH
- A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system
- (2016) Takuya Iizumi et al. Journal of Neuroinflammation
- AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550
- (2016) Min Sung Joo et al. MOLECULAR AND CELLULAR BIOLOGY
- PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species
- (2016) Noel A. Warfel et al. MOLECULAR CANCER THERAPEUTICS
- Oridonin inhibits the proliferation of human colon cancer cells by upregulating BMP7 to activate p38 MAPK
- (2016) CHUN-MEI REN et al. ONCOLOGY REPORTS
- Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells
- (2016) Yan Zhou et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The Dual Roles of NRF2 in Cancer
- (2016) Silvia Menegon et al. TRENDS IN MOLECULAR MEDICINE
- Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma
- (2016) F Ahmad et al. Cell Death & Disease
- Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis
- (2016) D Carlisi et al. Cell Death & Disease
- Elevated expression of Nrf2 mediates multidrug resistance in CD133+ head and neck squamous cell carcinoma stem cells
- (2016) Bao-Cai Lu et al. Oncology Letters
- p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
- (2016) Tetsuya Saito et al. Nature Communications
- Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance
- (2016) Youngtae Jeong et al. Cancer Discovery
- NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction
- (2016) Chao Zhang et al. Oncotarget
- Activation of AKT pathway by Nrf2/PDGFA feedback loop contributes to HCC progression
- (2016) Danyang Liu et al. Oncotarget
- Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway
- (2016) Yiying Wang et al. Oncotarget
- Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming
- (2016) Irene Riz et al. Oncotarget
- NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells
- (2016) Clarissa Ribeiro Reily Rocha et al. Oncotarget
- TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin
- (2016) Cao Xiaobo et al. Scientific Reports
- Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116 cells
- (2016) Yapeng Lu et al. Scientific Reports
- Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers
- (2016) Leonard D. Goldstein et al. Cell Reports
- NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming
- (2016) Kate E. Hawkins et al. Cell Reports
- Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib
- (2016) A. L. Furfaro et al. PLoS One
- NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG
- (2016) Shuya Kasai et al. PLoS One
- A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer
- (2015) Michael J. Bollong et al. ACS Chemical Biology
- Selective antagonization of activated Nrf2 and inhibition of cancer cell proliferation by procyanidins from Cinnamomi Cortex extract
- (2015) Tomokazu Ohnuma et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic
- (2015) Maria A. O’Connell et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Methylseleninic acid activates Keap1/Nrf2 pathway via up-regulating miR-200a in human oesophageal squamous cell carcinoma cells
- (2015) M. Liu et al. BIOSCIENCE REPORTS
- MiR-141 Activates Nrf2-Dependent Antioxidant Pathway via Down-Regulating the Expression of Keap1 Conferring the Resistance of Hepatocellular Carcinoma Cells to 5-Fluorouracil
- (2015) Liang Shi et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression
- (2015) Savan Kabaria et al. FREE RADICAL BIOLOGY AND MEDICINE
- Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway
- (2015) Alessandra Leone et al. FREE RADICAL BIOLOGY AND MEDICINE
- Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2
- (2015) Adedamola Olayanju et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
- (2015) Lauren E. Tebay et al. FREE RADICAL BIOLOGY AND MEDICINE
- The emerging role of Nrf2 in mitochondrial function
- (2015) Albena T. Dinkova-Kostova et al. FREE RADICAL BIOLOGY AND MEDICINE
- Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
- (2015) Xiaofang Sun et al. HEPATOLOGY
- Impact of nuclear factor erythroid-derived 2–like 2 and p62/sequestosome expression on prognosis of patients with gliomas
- (2015) Mingfei Zhao et al. HUMAN PATHOLOGY
- The complexity of the Nrf2 pathway: beyond the antioxidant response
- (2015) Ying Huang et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis
- (2015) Wafa Abu-Alainin et al. JOURNAL OF PATHOLOGY
- Reactive oxygen species mediate oridonin-induced apoptosis through DNA damage response and activation of JNK pathway in diffuse large B cell lymphoma
- (2015) Zi-Zhen Xu et al. LEUKEMIA & LYMPHOMA
- Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis
- (2015) Steffan Vartanian et al. MOLECULAR & CELLULAR PROTEOMICS
- Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation
- (2015) Shasha Yin et al. MOLECULAR AND CELLULAR BIOLOGY
- Aberrantly elevated redox sensing factor Nrf2 promotes cancer stem cell survival via enhanced transcriptional regulation of ABCG2 and Bcl-2/Bmi-1 genes
- (2015) YAN JIA et al. ONCOLOGY REPORTS
- Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells
- (2015) XIAO-QIAN ZHAO et al. Oncology Letters
- Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells
- (2015) In-geun Ryoo et al. Oncotarget
- Monitoring the Antioxidant Mediated Chemosensitization and ARE-Signaling in Triple Negative Breast Cancer Therapy
- (2015) Kira Foygel et al. PLoS One
- Understanding the role of NRF2-regulated miRNAs in human malignancies
- (2015) Niraj M Shah et al. Oncotarget
- Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress
- (2015) Yanira Gonzalez et al. Oncotarget
- Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer
- (2015) Fengjin Zhao et al. Oncotarget
- NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer
- (2015) Tatsuhiro Shibata et al. NEOPLASIA
- The PTEN/NRF2 Axis Promotes Human Carcinogenesis
- (2014) Ana I. Rojo et al. ANTIOXIDANTS & REDOX SIGNALING
- Nrf2 Overexpression Predicts Prognosis and 5-FU Resistance in Gastric Cancer
- (2014) Xiu-Feng Hu et al. Asian Pacific Journal of Cancer Prevention
- Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo
- (2014) Song Chian et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The single N-glycan deletion mutant of soluble ErbB3 protein attenuates heregulin β1-induced tumor progression by blocking of the HIF-1 and Nrf2 pathway
- (2014) Rina Takamiya et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway
- (2014) Xuefen Xu et al. BIOCHEMICAL PHARMACOLOGY
- AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells
- (2014) Brice Sid et al. BIOCHEMICAL PHARMACOLOGY
- Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells
- (2014) M Valenzuela et al. BRITISH JOURNAL OF CANCER
- MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis
- (2014) H Tian et al. CANCER GENE THERAPY
- Epigenetic DNA Methylation of Antioxidative Stress Regulator NRF2 in Human Prostate Cancer
- (2014) T. O. Khor et al. Cancer Prevention Research
- Myeloid Lineage-Specific Deletion of Antioxidant System Enhances Tumor Metastasis
- (2014) K. Hiramoto et al. Cancer Prevention Research
- Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
- (2014) S. Tao et al. CANCER RESEARCH
- NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival
- (2014) N M Shah et al. CELL DEATH AND DIFFERENTIATION
- Estrogen increases Nrf2 activity through activation of the PI3K pathway in MCF-7 breast cancer cells
- (2014) Juanjuan Wu et al. EXPERIMENTAL CELL RESEARCH
- The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2
- (2014) Ziming Li et al. FEBS LETTERS
- Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents
- (2014) Minh Truong Do et al. FREE RADICAL BIOLOGY AND MEDICINE
- Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells
- (2014) C. Qian et al. FREE RADICAL RESEARCH
- Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis
- (2014) T. Wu et al. GENES & DEVELOPMENT
- p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system
- (2014) MEIHUI XIA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Nrf2/p62 Signaling in Apoptosis Resistance and Its Role in Cadmium-induced Carcinogenesis
- (2014) Young-Ok Son et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy
- (2014) Hong-Min Ni et al. JOURNAL OF HEPATOLOGY
- Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes
- (2014) S. A. Rushworth et al. JOURNAL OF IMMUNOLOGY
- Transcription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing Enzymes
- (2014) T. Tsujita et al. MOLECULAR AND CELLULAR BIOLOGY
- Activation of Nrf2 Pathways Correlates with Resistance of NSCLC Cell Lines to CBP501 In Vitro
- (2014) N. Mine et al. MOLECULAR CANCER THERAPEUTICS
- Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?
- (2014) Tongde Wu et al. MOLECULAR CARCINOGENESIS
- Sequestosome 1/p62 facilitates HER2-induced mammary tumorigenesis through multiple signaling pathways
- (2014) X Cai-McRae et al. ONCOGENE
- Knockdown of nuclear factor erythroid 2-related factor 2 by lentivirus induces differentiation of glioma stem-like cells
- (2014) JIANHONG ZHU et al. ONCOLOGY REPORTS
- Convallatoxin, a Dual Inducer of Autophagy and Apoptosis, Inhibits Angiogenesis In Vitro and In Vivo
- (2014) Seung Ya Yang et al. PLoS One
- The Sensitivity of Cancer Cells to Pheophorbide a-Based Photodynamic Therapy Is Enhanced by NRF2 Silencing
- (2014) Bo-hyun Choi et al. PLoS One
- Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway
- (2014) C. Gorrini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer
- (2014) Annette Hayden et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Cytoprotection “gone astray’’: Nrf2 and its role in cancer
- (2014) Heiner Schafer et al. OncoTargets and Therapy
- Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation
- (2014) K A Kang et al. Cell Death & Disease
- The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response
- (2014) M Hussong et al. Cell Death & Disease
- SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation
- (2014) Shanshan Pang et al. Nature Communications
- Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer
- (2014) Victor D. Martinez et al. Biomed Research International
- Oridonin Induces Apoptosis, Inhibits Migration and Invasion on Highly-Metastatic Human Breast Cancer Cells
- (2013) Shengpeng Wang et al. AMERICAN JOURNAL OF CHINESE MEDICINE
- Nrf2 affects the efficiency of mitochondrial fatty acid oxidation
- (2013) Marthe H. R. Ludtmann et al. BIOCHEMICAL JOURNAL
- Synergistic inhibition of mesothelioma cell growth by the combination of clofarabine and resveratrol involves Nrf2 downregulation
- (2013) Yoon-Jin Lee et al. BMB Reports
- Feedback loop between p66Shc and Nrf2 promotes lung cancer progression
- (2013) Wei Du et al. CANCER LETTERS
- KEAP1 Is a Redox Sensitive Target That Arbitrates the Opposing Radiosensitive Effects of Parthenolide in Normal and Cancer Cells
- (2013) Y. Xu et al. CANCER RESEARCH
- Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination
- (2013) B. E. Hast et al. CANCER RESEARCH
- CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
- (2013) A. Ooi et al. CANCER RESEARCH
- Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination
- (2013) B. E. Hast et al. CANCER RESEARCH
- Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
- (2013) Hironori Satoh et al. CANCER RESEARCH
- Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway
- (2013) Ai-Mei Gao et al. CARCINOGENESIS
- MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis
- (2013) B. Singh et al. CARCINOGENESIS
- Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway
- (2013) Ai-Mei Gao et al. CHEMICO-BIOLOGICAL INTERACTIONS
- The Noncytotoxic Dose of Sorafenib Sensitizes Bel-7402/5-FU Cells to 5-FU by Down-Regulating 5-FU-Induced Nrf2 Expression
- (2013) Suna Zhou et al. DIGESTIVE DISEASES AND SCIENCES
- Parthenolide: from plant shoots to cancer roots
- (2013) Akram Ghantous et al. DRUG DISCOVERY TODAY
- Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs
- (2013) Takumi Satoh et al. FREE RADICAL BIOLOGY AND MEDICINE
- Regulation of Nrf2—an update
- (2013) Suryakant K. Niture et al. FREE RADICAL BIOLOGY AND MEDICINE
- Identification of driver genes in hepatocellular carcinoma by exome sequencing
- (2013) Sean P. Cleary et al. HEPATOLOGY
- Retinoids and their biological effects against cancer
- (2013) Fatemeh Alizadeh et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine
- (2013) HONG-QUAN DUONG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis
- (2013) Anju Singh et al. JOURNAL OF CLINICAL INVESTIGATION
- A Somatic Mutation of the KEAP1 Gene in Malignant Melanoma Is Involved in Aberrant NRF2 Activation and an Increase in Intrinsic Drug Resistance
- (2013) Shinpei Miura et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner
- (2013) A. Lau et al. MOLECULAR AND CELLULAR BIOLOGY
- Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer
- (2013) Victor D Martinez et al. Molecular Cancer
- The Impact of miRNA-Based Molecular Diagnostics and Treatment of NRF2-Stabilized Tumors
- (2013) Shinsuke Yamamoto et al. MOLECULAR CANCER RESEARCH
- Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
- (2013) Yoshinobu Ichimura et al. MOLECULAR CELL
- ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells
- (2013) ZI-XIANG CONG et al. ONCOLOGY REPORTS
- Novel Hematopoietic Target Genes in the NRF2-Mediated Transcriptional Pathway
- (2013) Michelle R. Campbell et al. Oxidative Medicine and Cellular Longevity
- Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells
- (2013) Roberta Foresti et al. PHARMACOLOGICAL RESEARCH
- Nrf2 Pathway Regulates Multidrug-Resistance-Associated Protein 1 in Small Cell Lung Cancer
- (2013) Lili Ji et al. PLoS One
- Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways
- (2013) Minh Truong Do et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer
- (2013) A D'Anneo et al. Cell Death & Disease
- Keap1 mutations in lung cancer patients
- (2013) HIDEFUMI SASAKI et al. Oncology Letters
- Involvement of Nrf2-Mediated Upregulation of Heme Oxygenase-1 in Mollugin-Induced Growth Inhibition and Apoptosis in Human Oral Cancer Cells
- (2013) Young-Man Lee et al. Biomed Research International
- DNA Damage and Oxidative Stress in Human Disease
- (2013) Sharbel Weidner Maluf et al. Biomed Research International
- Astroglial Pentose Phosphate Pathway Rates in Response to High-Glucose Environments
- (2012) Shinichi Takahashi et al. ASN Neuro
- A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells
- (2012) Duo Guo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance
- (2012) S. A. Rushworth et al. BLOOD
- Methylation of the KEAP1 gene promoter region in human colorectal cancer
- (2012) Naoyuki Hanada et al. BMC CANCER
- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- AberrantKeap1methylation in breast cancer and association with clinicopathological features
- (2012) Raffaela Barbano et al. Epigenetics
- The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops
- (2012) Diána Papp et al. FEBS LETTERS
- NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: Implications for tumor growth retardation and docetaxel sensitivity
- (2012) Sarala Manandhar et al. FREE RADICAL BIOLOGY AND MEDICINE
- Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein
- (2012) Nathan D. Camp et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis
- (2012) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function
- (2012) J. Ma et al. MOLECULAR AND CELLULAR BIOLOGY
- Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response
- (2012) Yan Zhong et al. MOLECULAR CARCINOGENESIS
- MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas
- (2012) HIDEFUMI SASAKI et al. Molecular Medicine Reports
- Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
- (2012) Tracy L Keller et al. Nature Chemical Biology
- Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
- (2012) Cécile Guichard et al. NATURE GENETICS
- Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks
- (2012) Yosuke Hirotsu et al. NUCLEIC ACIDS RESEARCH
- Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity
- (2012) A Arlt et al. ONCOGENE
- Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
- (2012) S Chowdhry et al. ONCOGENE
- Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal, SH-SY5Y Cells
- (2012) Madhusudhanan Narasimhan et al. PLoS One
- Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages
- (2011) Nobuhiko Harada et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract
- (2011) Tomokazu Ohnuma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
- (2011) Muhua Yang et al. BREAST CANCER RESEARCH AND TREATMENT
- An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
- (2011) Aikseng Ooi et al. CANCER CELL
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
- (2011) Julie Adam et al. CANCER CELL
- Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer
- (2011) P. A. Konstantinopoulos et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Regulation ofKEAP1expression by promoter methylation in malignant gliomas and association with patient’s outcome
- (2011) Lucia Anna Muscarella et al. Epigenetics
- Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer
- (2011) Lucia Anna Muscarella et al. Epigenetics
- Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs
- (2011) Xiuwen Tang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Parthenolide, a Sesquiterpene Lactone, Expresses Multiple Anti-cancer and Anti-inflammatory Activities
- (2011) Vivek Bhakta Mathema et al. INFLAMMATION
- Association of Keap1 and Nrf2 Genetic Mutations and Polymorphisms With Endometrioid Endometrial Adenocarcinoma Survival
- (2011) Tze Fang Wong et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells
- (2011) Gabriel Eades et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- miR-200a Regulates Nrf2 Activation by TargetingKeap1mRNA in Breast Cancer Cells
- (2011) Gabriel Eades et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Heme Oxygenase-1 Protein Is Overexpressed in Human Renal Cancer Cells following Activation of the Ras-Raf-ERK Pathway and Mediates Anti-Apoptotic Signal
- (2011) Pallavi Banerjee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
- (2011) Yoshihiro Inami et al. JOURNAL OF CELL BIOLOGY
- KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma
- (2011) Qing Kay Li et al. JOURNAL OF HUMAN GENETICS
- Berberine Suppresses the TPA-Induced MMP-1 and MMP-9 Expressions Through the Inhibition of PKC-α in Breast Cancer Cells
- (2011) Sangmin Kim et al. JOURNAL OF SURGICAL RESEARCH
- SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
- (2011) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy
- (2011) Adam Lister et al. Molecular Cancer
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- Seven Quassinoids from Fructus Bruceae with Cytotoxic Effects on Pancreatic Adenocarcinoma Cell Lines
- (2011) M. Zhao et al. PHYTOTHERAPY RESEARCH
- Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
- (2011) D. Ren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption
- (2011) Kai Connie Wu et al. TOXICOLOGICAL SCIENCES
- NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease
- (2011) A. Boutten et al. TRENDS IN MOLECULAR MEDICINE
- Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism
- (2010) Jiansheng Huang et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- A NADPH Oxidase–Dependent Redox Signaling Pathway Mediates the Selective Radiosensitization Effect of Parthenolide in Prostate Cancer Cells
- (2010) Yulan Sun et al. CANCER RESEARCH
- High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer
- (2010) T. Jiang et al. CANCER RESEARCH
- Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung
- (2010) Hironori Satoh et al. CARCINOGENESIS
- Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features
- (2010) L. M. Solis et al. CLINICAL CANCER RESEARCH
- Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway
- (2010) Ian M. Copple et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
- (2010) Ashish Jain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer
- (2010) Tsuyoshi Takahashi et al. JOURNAL OF SURGICAL ONCOLOGY
- A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
- (2010) A. Lau et al. MOLECULAR AND CELLULAR BIOLOGY
- Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth
- (2010) P. Zhang et al. MOLECULAR CANCER THERAPEUTICS
- The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
- (2010) Masaaki Komatsu et al. NATURE CELL BIOLOGY
- Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
- (2010) Deepti Malhotra et al. NUCLEIC ACIDS RESEARCH
- Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice
- (2010) Siwang Yu et al. PLoS One
- A new triterpenoid from Brucea javanica
- (2009) Jian Hua Liu et al. ARCHIVES OF PHARMACAL RESEARCH
- Functional Identification of Tumor-Suppressor Genes through an In Vivo RNA Interference Screen in a Mouse Lymphoma Model
- (2009) Anka Bric et al. CANCER CELL
- Brucein D induces apoptosis in pancreatic adenocarcinoma cell line PANC-1 through the activation of p38-mitogen activated protein kinase
- (2009) Sin Ting Lau et al. CANCER LETTERS
- Silencing MRP4 by small interfering RNA reverses acquired DDP resistance of gastric cancer cell
- (2009) Yan-Hong Zhang et al. CANCER LETTERS
- Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer
- (2009) S. Homma et al. CLINICAL CANCER RESEARCH
- Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations
- (2009) Jun Tang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
- (2009) Yoo Ri Kim et al. JOURNAL OF PATHOLOGY
- Critical Cysteine Residues of Kelch-Like ECH-Associated Protein 1 in Arsenic Sensing and Suppression of Nuclear Factor Erythroid 2-Related Factor 2
- (2009) X. He et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
- (2009) Weimin Chen et al. MOLECULAR CELL
- NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation
- (2009) X. He et al. MOLECULAR PHARMACOLOGY
- Cysteine-based regulation of the CUL3 adaptor protein Keap1
- (2009) Konjeti R. Sekhar et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Targeting NRF2 signaling for cancer chemoprevention
- (2009) Mi-Kyoung Kwak et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease
- (2008) Marcus J. Calkins et al. ANTIOXIDANTS & REDOX SIGNALING
- Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
- (2008) Rui Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth
- (2008) T. Ohta et al. CANCER RESEARCH
- Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
- (2008) X.-J. Wang et al. CARCINOGENESIS
- Prospective Type 1 and Type 2 Disulfides of Keap1 Protein
- (2008) Ryan Holland et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer
- (2008) Tatsuhiro Shibata et al. GASTROENTEROLOGY
- Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity
- (2008) T. Yamamoto et al. MOLECULAR AND CELLULAR BIOLOGY
- The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds
- (2008) M. Kobayashi et al. MOLECULAR AND CELLULAR BIOLOGY
- Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines
- (2008) Sin Ting Lau et al. PHYTOTHERAPY RESEARCH
- Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine
- (2008) Mohsen Imanshahidi et al. PHYTOTHERAPY RESEARCH
- Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
- (2008) T. Shibata et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica
- (2008) Saw Bawm et al. VETERINARY PARASITOLOGY
- Protein Damage by Reactive Electrophiles: Targets and Consequences
- (2007) Daniel C. Liebler CHEMICAL RESEARCH IN TOXICOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started