Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 32, Issue 5, Pages 661-666Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-009-1503-8
Keywords
Brucea javanica; Triterpenoid; Bruceajavanin C; NO production
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A new triterpenoid, bruceajavanin C (1), together with bruceosides A and B (2 and 3), bruceines D and E (4 and 5), yadanziosides A and G (6 and 7), (20R)-O-(3)-alpha-L-arabinopyranosylpregn-5-ene-3 beta,20-diol (8), and alpha-D-glucopyranoside, (3 beta, 20R)-3-hydroxypregn-5-en-20-yl (9) were isolated from the aerial parts of Brucea javanica. The structure of 1 was elucidated on the basis of 2D-NMR spectroscopic analysis. In addition, compounds 1, 3, 4, 5, and 6 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.
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