Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs

miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1

(2017) Burak Akdemir et al.   MOLECULAR CANCER RESEARCH

MicroRNA-144 modulates oxidative stress tolerance in SH-SY5Y cells by regulating nuclear factor erythroid 2-related factor 2-glutathione axis

(2017) Chunlei Zhou et al.   NEUROSCIENCE LETTERS

CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells

(2017) Q Wang et al.   ONCOGENE

MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells

(2017) Chengzhi Chen et al.   TOXICOLOGY LETTERS

Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma

(2017) Federico Pio Fabrizio et al.   Oncotarget

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

(2017) Elsa B Krall et al.   eLife

The KEAP1–NRF2 System in Cancer

(2017) Keiko Taguchi et al.   Frontiers in Oncology

MicroRNA-153 Regulates NRF2 Expression and is Associated with Breast Carcinogenesis

(2016) Bo Wang et al.   Clinical Laboratory

Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad

(2016) Angelo Sparaneo et al.   Oxidative Medicine and Cellular Longevity

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

(2016) Youngtae Jeong et al.   Cancer Discovery

Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region

(2016) Xiongxiong Liu et al.   Oncotarget

Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells

(2016) Kyoung Ah Kang et al.   Oncotarget

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

(2016) Leonard D. Goldstein et al.   Cell Reports

NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming

(2016) Kate E. Hawkins et al.   Cell Reports

Keap1/Nrf2 impairing revised: are we missing the single nucleotide polymorphisms?

(2016) Lucia Anna Muscarella et al.   Journal of Thoracic Disease

Loss of miR-140 is a key risk factor for radiation-induced lung fibrosis through reprogramming fibroblasts and macrophages

(2016) Nadire Duru et al.   Scientific Reports

miR-340 Reverses Cisplatin Resistance of Hepatocellular Carcinoma Cell Lines by Targeting Nrf2-dependent Antioxidant Pathway

(2015) Liang Shi et al.   Asian Pacific Journal of Cancer Prevention

Cross-cancer profiling of molecular alterations within the human autophagy interaction network

(2015) Chandra B Lebovitz et al.   Autophagy

Methylseleninic acid activates Keap1/Nrf2 pathway via up-regulating miR-200a in human oesophageal squamous cell carcinoma cells

(2015) M. Liu et al.   BIOSCIENCE REPORTS

NRF2/miR-140 signaling confers radioprotection to human lung fibroblasts

(2015) Nadire Duru et al.   CANCER LETTERS

MiR-141 Activates Nrf2-Dependent Antioxidant Pathway via Down-Regulating the Expression of Keap1 Conferring the Resistance of Hepatocellular Carcinoma Cells to 5-Fluorouracil

(2015) Liang Shi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2

(2015) R. J. G. Cardnell et al.   CLINICAL CANCER RESEARCH

Keap1-Nrf2 Interaction Suppresses Cell Motility in Lung Adenocarcinomas by Targeting the S100P Protein

(2015) M.-H. Chien et al.   CLINICAL CANCER RESEARCH

KEAP1 Genetic Polymorphisms Associate with Breast Cancer Risk and Survival Outcomes

(2015) J. M. Hartikainen et al.   CLINICAL CANCER RESEARCH

NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma

(2015) D. W. Cescon et al.   CLINICAL CANCER RESEARCH

Keap1 expression has independent prognostic value in pancreatic adenocarcinomas

(2015) Joel Isohookana et al.   Diagnostic Pathology

MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression

(2015) Savan Kabaria et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic Landscape and Biomarkers of Hepatocellular Carcinoma

(2015) Jessica Zucman-Rossi et al.   GASTROENTEROLOGY

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria

(2015) Ken Itoh et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

The complexity of the Nrf2 pathway: beyond the antioxidant response

(2015) Ying Huang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis

(2015) Wafa Abu-Alainin et al.   JOURNAL OF PATHOLOGY

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

(2015) Michal Kovac et al.   Nature Communications

Abstract 1531: Cross-entity mutation analysis of lung neuroendocrine tumors sheds light into their molecular origin and identifies new therapeutic targets

(2015) Lynnette Fernandez-Cuesta et al.   CANCER RESEARCH

MicroRNAome genome: A treasure for cancer diagnosis and therapy

(2014) Ioana Berindan-Neagoe et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Epigenetic DNA Methylation of Antioxidative Stress Regulator NRF2 in Human Prostate Cancer

(2014) T. O. Khor et al.   Cancer Prevention Research

The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2

(2014) Ziming Li et al.   FEBS LETTERS

Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms: Association with poor prognosis in head and neck cancer

(2014) Victor D. Martinez et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

NRF2/Long Noncoding RNA ROR Signaling Regulates Mammary Stem Cell Expansion and Protects against Estrogen Genotoxicity

(2014) Yongshu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genomic landscape of hepatoblastoma and their progenies with HCC-like features

(2014) Melanie Eichenmüller et al.   JOURNAL OF HEPATOLOGY

Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients

(2014) Masayuki Kanamori et al.   NEURO-ONCOLOGY

Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation

(2014) K A Kang et al.   Cell Death & Disease

Determining Effects of Non-synonymous SNPs on Protein-Protein Interactions using Supervised and Semi-supervised Learning

(2014) Nan Zhao et al.   PLoS Computational Biology

Characterization of a Novel Long Noncoding RNA, SCAL1, Induced by Cigarette Smoke and Elevated in Lung Cancer Cell Lines

(2013) Philip Thai et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma

(2013) A. Ooi et al.   CANCER RESEARCH

MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis

(2013) B. Singh et al.   CARCINOGENESIS

Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway

(2013) Mohammed Qaisiya et al.   CELLULAR SIGNALLING

The Impact of miRNA-Based Molecular Diagnostics and Treatment of NRF2-Stabilized Tumors

(2013) Shinsuke Yamamoto et al.   MOLECULAR CANCER RESEARCH

Integrated molecular analysis of clear-cell renal cell carcinoma

(2013) Yusuke Sato et al.   NATURE GENETICS

A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells

(2012) Duo Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes

(2012) Weihong Hou et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Methylation of the KEAP1 gene promoter region in human colorectal cancer

(2012) Naoyuki Hanada et al.   BMC CANCER

Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL

(2012) Hui Tian et al.   CANCER LETTERS

AberrantKeap1methylation in breast cancer and association with clinicopathological features

(2012) Raffaela Barbano et al.   Epigenetics

The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops

(2012) Diána Papp et al.   FEBS LETTERS

Somatic mutations of the KEAP1 gene in common solid cancers

(2012) Nam Jin Yoo et al.   HISTOPATHOLOGY

Increased NRF2 gene (NFE2L2) copy number correlates with mutations in lung squamous cell carcinomas

(2012) HIDEFUMI SASAKI et al.   Molecular Medicine Reports

microRNA-155 silencing inhibits proliferation and migration and induces apoptosis by upregulating BACH1 in renal cancer cells

(2012) SONGCHAO LI et al.   Molecular Medicine Reports

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci

(2012) Satish Sati et al.   NUCLEIC ACIDS RESEARCH

Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs

(2012) V. A. Moran et al.   NUCLEIC ACIDS RESEARCH

miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells

(2012) M T M van Jaarsveld et al.   ONCOGENE

Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers

(2012) T Yamadori et al.   ONCOGENE

Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal, SH-SY5Y Cells

(2012) Madhusudhanan Narasimhan et al.   PLoS One

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

(2012) Yoichiro Mitsuishi et al.   Frontiers in Oncology

MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism

(2011) Muhua Yang et al.   BREAST CANCER RESEARCH AND TREATMENT

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

(2011) P. A. Konstantinopoulos et al.   CANCER RESEARCH

The Role of NF-E2-Related Factor 2 in Predicting Chemoresistance and Prognosis in Advanced Non–Small-Cell Lung Cancer

(2011) Haihong Yang et al.   Clinical Lung Cancer

Regulation ofKEAP1expression by promoter methylation in malignant gliomas and association with patient’s outcome

(2011) Lucia Anna Muscarella et al.   Epigenetics

Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer

(2011) Lucia Anna Muscarella et al.   Epigenetics

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells

(2011) Gabriel Eades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-200a Regulates Nrf2 Activation by TargetingKeap1mRNA in Breast Cancer Cells

(2011) Gabriel Eades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma

(2011) Qing Kay Li et al.   JOURNAL OF HUMAN GENETICS

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

(2011) Adam Lister et al.   Molecular Cancer

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Single-Nucleotide Polymorphisms Inside MicroRNA Target Sites Influence Tumor Susceptibility

(2010) Milena S. Nicoloso et al.   CANCER RESEARCH

Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features

(2010) L. M. Solis et al.   CLINICAL CANCER RESEARCH

Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

(2010) P. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins

(2009) Weihong Hou et al.   HEPATOLOGY

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

(2009) Yoo Ri Kim et al.   JOURNAL OF PATHOLOGY

Identification of Keratinocyte Growth Factor as a Target of microRNA-155 in Lung Fibroblasts: Implication in Epithelial-Mesenchymal Interactions

(2009) Nicolas Pottier et al.   PLoS One

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

(2008) Rui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

let-7 regulates Dicer expression and constitutes a negative feedback loop

(2008) Shogo Tokumaru et al.   CARCINOGENESIS

Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

(2008) Tatsuhiro Shibata et al.   GASTROENTEROLOGY