Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer

Nrf2 Is Commonly Activated in Papillary Thyroid Carcinoma, and It Controls Antioxidant Transcriptional Responses and Viability of Cancer Cells

(2013) Panos G. Ziros et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

New Insights into FoxE1 Functions: Identification of Direct FoxE1 Targets in Thyroid Cells

(2013) Lara P. Fernández et al.   PLoS One

Identification of a KEAP1 Germline Mutation in a Family with Multinodular Goitre

(2013) Risa Teshiba et al.   PLoS One

A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells

(2012) Duo Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Methylation of the KEAP1 gene promoter region in human colorectal cancer

(2012) Naoyuki Hanada et al.   BMC CANCER

Nrf2: Friend and Foe in Preventing Cigarette Smoking-Dependent Lung Disease

(2012) Thomas Müller et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The transcription factor NF-E2-related Factor 2 (Nrf2): a protooncogene?

(2012) Phillip Shelton et al.   FASEB JOURNAL

Genetic Disruption of KEAP1/CUL3 E3 Ubiquitin Ligase Complex Components is a Key Mechanism of NF-KappaB Pathway Activation in Lung Cancer

(2011) Kelsie L. Thu et al.   Journal of Thoracic Oncology

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Oxidative Stress

(2010) Sylvie Poncin et al.   AMERICAN JOURNAL OF PATHOLOGY

Minimal oxidative load: a prerequisite for thyroid cell function

(2009) Sylvie Poncin et al.   JOURNAL OF ENDOCRINOLOGY

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL