Article
Cell Biology
Myungjin Lee, Hae Yun Nam, Hee-Bum Kang, Won Hyeok Lee, Geun-Hee Lee, Gi-Jun Sung, Myung Woul Han, Kyung-Ja Cho, Eun-Ju Chang, Kyung-Chul Choi, Seong Who Kim, Sang Yoon Kim
Summary: Tumors contain subpopulations of cancer cells with distinct functionalities, which limit the effectiveness of cancer drugs. Understanding the regulatory mechanisms driving subclonal variation within therapy-resistant tumors can provide novel treatment options to overcome resistance to current therapies.
CELL DEATH & DISEASE
(2021)
Article
Veterinary Sciences
Kaiyi Pang, Shujie Wang, Meng Li, Zhenlei Zhou
Summary: This study investigated the effects of MP and 3-MA on chondrocyte autophagy and bone quality in broilers, revealing that autophagy may play a role in MP-induced femoral head necrosis in broilers.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Biochemistry & Molecular Biology
Qing Shi, Xiaofeng Jin, Pingzhao Zhang, Qian Li, Zeheng Lv, Yan Ding, Huiying He, Yijun Wang, Yuanlong He, Xiaying Zhao, Shi-Min Zhao, Yao Li, Kun Gao, Chenji Wang
Summary: This study reveals that SPOP mutations induce non-degradative ubiquitination of p62, leading to suppression of p62-dependent autophagy and decreased Nrf2-mediated transcriptional activation of antioxidant genes, thus promoting tumor formation in SPOP-mutated PCa.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Samantha T. Bradley, Yong-Syu Lee, Zafer Gurel, Randall J. Kimple
Summary: Autophagy is an evolutionarily conserved cell survival mechanism that degrades damaged proteins and organelles to generate cellular energy during times of stress. Dysregulation of autophagy can lead to various human diseases and cancers due to its complexity in regulating vital cellular functions. The role of autophagy in cancer development, progression, and treatment is complex, especially given its modulation by most cancer therapies.
MOLECULAR CARCINOGENESIS
(2022)
Article
Genetics & Heredity
Xiuying Chen, Li Yu, Junyang Zhou, Ji Ren, Shan Wang, Yujie Tan, Yan Ding
Summary: In esophageal squamous cell carcinoma, both NFE2L2 and SQSTM1 (p62) are upregulated and promote tumor progression and epithelial-mesenchymal transition (EMT) through autophagy activity. Inhibiting both proteins simultaneously can reverse the migration and EMT characteristics of the tumor, suggesting that targeting both proteins may be a viable treatment option for esophageal squamous cell carcinoma.
Article
Cell Biology
Aude Jehl, Ombline Conrad, Mickael Burgy, Sophie Foppolo, Romain Vauchelles, Carole Ronzani, Nelly Etienne-Selloum, Marie-Pierre Chenard, Aurelien Danic, Thomas Dourlhes, Claire Thibault, Philippe Schultz, Monique Dontenwill, Sophie Martin
Summary: This study found that the inactivation of Epiregulin (EREG) can increase the sensitivity of head and neck squamous cell carcinoma cells to cetuximab (CTX), and is associated with cellular metabolic disorder, iron accumulation, and lipid peroxidation. Therefore, the loss of EREG may serve as a predictive biomarker in clinical settings for patients who may undergo ferroptosis in response to CTX, and who may benefit the most from the combination therapy of ferroptosis inducers and CTX.
Article
Oncology
Sheng Wang, Wei Feng, Wulin Wang, Xiaoman Ye, Hao Chen, Chunzhao Yu
Summary: This study aims to increase the sensitivity of gemcitabine chemotherapy for pancreatic cancer by silencing the Girdin gene, showing that Girdin may enhance chemotherapy resistance to gemcitabine through regulating autophagy activity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Masakazu Hamada, Hiroaki Inaba, Kyoko Nishiyama, Sho Yoshida, Yoshiaki Yura, Michiyo Matsumoto-Nakano, Narikazu Uzawa
Summary: This study found that up-regulated autophagy-related genes and other genes in serum-starved cells are associated with the initiation and progression of head and neck squamous cell carcinoma. Further analysis revealed high expression of CALR, HSPA5, and TRIB3 in HNSCC patients to be correlated with poor prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Kyung-Ran Park, Hanna Lee, Soo Hyun Kim, Hyung-Mun Yun
Summary: Paonia suffruticosa has been used as a medicinal plant in Asian countries. This study investigated the anti-cancer effects of a compound isolated from P. suffruticosa on head and neck squamous cell carcinomas (HNSCCs). The compound inhibited cell proliferation and induced apoptotic cell death in HNSCC cells, and also affected necroptosis and autophagy.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Milica Kosic, Verica Paunovic, Biljana Ristic, Aleksandar Mircic, Mihajlo Bosnjak, Danijela Stevanovic, Tamara Kravic-Stevovic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic
Summary: The study showed that 3-methyladenine (3MA) can prevent cancer cell death induced by energy stress through autophagy-independent mechanisms, possibly involving JNK suppression and decrease of oxidative stress. It highlights the need for caution when using 3MA as an autophagy inhibitor.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Immunology
Jiamei Zhang, Lu Han, Qinmei Ma, Xiaoping Wang, Jialin Yu, Yanan Xu, Xu Zhang, Xiaoling Wu, Guangcun Deng
Summary: It has been found that RIP3 plays a crucial role in fighting against Mycobacterium tuberculosis (M.tb) infection by promoting autophagy, which enhances host clearance of the bacteria.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Maria Isabel Alvarez-Mora, Gloria Garrabou, Laura Molina-Porcel, Ruben Grillo-Risco, Francisco Garcia-Garcia, Tamara Barcos, Judith Canto-Santos, Laia Rodriguez-Revenga
Summary: This study investigated the expression levels of SUMO2/3 and the autophagy process in samples from FXTAS patients. The results showed that SUMO2/3 accumulation is involved in inclusion formation, and the autophagy process is downregulated in FXTAS. These findings provide new evidence for the role of SUMOylation and autophagic processes in the pathogenic mechanisms underlying FXTAS.
Article
Plant Sciences
Xiaojie Liu, Lu Liu, Xu Wang, Yubin Jin, Shuang Wang, Qin Xie, Yanhe Jin, Mengli Zhang, Yunhe Liu, Jinfeng Li, Zhenya Wang, Xiangjing Fu, Cheng-Yun Jin
Summary: The study aimed to investigate the role of shikonin in bladder cancer and its underlying mechanisms in vitro and in vivo. Shikonin showed selective inhibitory effect on bladder cancer cells without toxicity on normal bladder epithelial cells. Mechanically, shikonin induced necroptosis and impaired autophagic flux through ROS generation. The crosstalk between necroptosis and autophagy was also observed.
Review
Biochemistry & Molecular Biology
Yong Teng, Lixia Gao, Antti A. Makitie, Ewa Florek, Agata Czarnywojtek, Nabil F. Saba, Alfio Ferlito
Summary: This review discusses the relationship between ferroptosis and head and neck cancer treatment, including its conceptual framework, mechanism, functional aspects, and implications for tumor therapy. In addition, strategies for improving the efficacy of head and neck cancer treatment through modulation of ferroptosis are summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
Jong-Lyel Roh, Jaewang Lee, Hyejin Jang, Eun Hye Kim, Daiha Shin
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2018)
Article
Otorhinolaryngology
Jaewang Lee, Daiha Shin, Jong-Lyel Roh
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Engineering, Biomedical
Jaewang Lee, Daiha Shin, Jong-Lyel Roh
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2019)
Article
Biochemistry & Molecular Biology
Daiha Shin, Jaewang Lee, Ji Hyeon You, Doyeon Kim, Jong-Lyel Roh
Article
Oncology
Jaewang Lee, Ji Hyeon You, Daiha Shin, Jong-Lyel Roh
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Jaewang Lee, Ji Hyeon You, Min-Su Kim, Jong-Lyel Roh
Article
Oncology
Ji Hyeon You, Jaewang Lee, Jong-Lyel Roh
Summary: This study indicates that regulation of the KDM5A-MPC1 axis can enhance cancer cells' susceptibility to ferroptosis by inducing mesenchymal traits, and low expression of MPC1 is associated with poor overall survival in patients.
Article
Oncology
Ji Hyeon You, Jaewang Lee, Jong-Lyel Roh
Summary: The study highlights that PGRMC1 promotes ferroptosis in paclitaxel-tolerant persister cancer cells (PCC) by affecting lipid metabolism and xCT inhibition. These findings reveal the mechanism of PGRMC1 in regulating ferroptosis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Dong-Hoon Hyun, Jaewang Lee
Summary: Neurodegenerative diseases are characterized by oxidative stress and mitochondrial dysfunction, which result in the loss of neuronal cells and the formation of protein aggregates. Altered cellular signaling, deficiency in antioxidant enzymes, and reduced levels of antioxidants contribute to the progression of these diseases. Mitochondrial dysfunction, caused by oxidative damage and impaired cellular signaling, plays a significant role in the early stages of neurodegenerative diseases. Improving mitochondrial function and maintaining redox homeostasis are important therapeutic strategies for delaying disease progression.
Article
Biochemistry & Molecular Biology
Jaewang Lee, Ji Hyeon You, Jong-Lyel Roh
Summary: This study reveals the role of PCBP1 in regulating ferritinophagy-mediated ferroptosis in head and neck cancer cells. PCBP1 attenuates cancer susceptibility to ferroptosis inducers by repressing the expression of BECN1 and ALOX15 mRNA.
Article
Pharmacology & Pharmacy
Jaewang Lee, Daiha Shin, Jong-Lyel Roh
Summary: Cancer disrupts lipid metabolism, leading to altered metabolism intermediates and contributing to abnormal growth and metastasis. The shift in lipid metabolism towards an increased presence of polyunsaturated fatty acids (PUFAs) in membrane phospholipids (PLs) also causes resistance to cancer therapy. The vulnerability of cancer cells to lipid peroxidation (LPO) and subsequent ferroptosis, a new form of regulated cell death, depends on adaptive lipidome remodeling, LPO patterns, and LPO scavenging ability. Understanding the molecular basis of altered lipid metabolism in cancer may offer new opportunities for overcoming cancer resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jaewang Lee, Jong-Lyel Roh
Summary: SLC7A11 is a cell transmembrane protein that plays a critical role in maintaining redox homeostasis and has implications in cancer development and treatment. Further understanding of its functions could lead to novel cancer therapeutics.
Review
Biochemistry & Molecular Biology
Jaewang Lee, Dong-Hoon Hyun
Summary: Iron is essential for life, but dysregulation of intracellular iron homeostasis can produce excessive reactive oxygen species (ROS) and cause cell death. The intracellular system regulates iron levels through various mechanisms, including hepcidin-ferroportin, DMT1-transferrin, and ferritin-NCOA4. These processes are regulated by the IRP/IRE system and Nrf2.
Article
Medicine, Research & Experimental
Jaewang Lee, Ji Hyeon You, Daiha Shin, Jong-Lyel Roh
Article
Medicine, Research & Experimental
Jaewang Lee, Daiha Shin, Jong-Lyel Roh