Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism
Authors
Keywords
-
Journal
ONCOGENE
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2018-06-19
DOI
10.1038/s41388-018-0360-7
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Effects of metformin on endometrial cancer: Systematic review and meta-analysis
- (2017) Cinthia G. Meireles et al. GYNECOLOGIC ONCOLOGY
- CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors
- (2017) Caner Saygin et al. JOURNAL OF EXPERIMENTAL MEDICINE
- NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1α and p27Kip1 expression in malignant melanoma and other human tumors
- (2017) Smitha Antony et al. MOLECULAR CARCINOGENESIS
- Metformin augments doxorubicin cytotoxicity in mammary carcinoma through activation of adenosine monophosphate protein kinase pathway
- (2017) Nahla E El-Ashmawy et al. TUMOR BIOLOGY
- Metformin and temozolomide, a synergic option to overcome resistance in glioblastoma multiforme models
- (2017) Silvia Valtorta et al. Oncotarget
- Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation
- (2017) Andrea E. Calvert et al. Cell Reports
- Increased TET1 Expression in Inflammatory Microenvironment of Hyperinsulinemia Enhances the Response of Endometrial Cancer to Estrogen by Epigenetic Modulation of GPER
- (2017) Qiao-Ying Lv et al. Journal of Cancer
- Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma
- (2016) Zhihong Zhuo et al. ARCHIVES OF GYNECOLOGY AND OBSTETRICS
- Combinational strategies of metformin and chemotherapy in cancers
- (2016) Hui-Hui Zhang et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Infiltrating Macrophages Induce ERα Expression through an IL17A-mediated Epigenetic Mechanism to Sensitize Endometrial Cancer Cells to Estrogen
- (2016) Chengcheng Ning et al. CANCER RESEARCH
- Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer
- (2016) D S Matassa et al. CELL DEATH AND DIFFERENTIATION
- Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
- (2016) Andrew P. Feinberg et al. NATURE REVIEWS GENETICS
- EGFR, p53, IDH-1 and MDM2 immunohistochemical analysis in glioblastoma: therapeutic and prognostic correlation
- (2015) Richard Murdoch Montgomery et al. ARQUIVOS DE NEURO-PSIQUIATRIA
- Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198
- (2015) R. J. Molenaar et al. CANCER RESEARCH
- Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes
- (2015) Tao Xu et al. DIABETES CARE
- Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis
- (2015) Adrian V. Hernandez et al. EUROPEAN JOURNAL OF CANCER
- HighIDH1expression is associated with a poor prognosis in cytogenetically normal acute myeloid leukemia
- (2015) Qiu-Ling Ma et al. INTERNATIONAL JOURNAL OF CANCER
- Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
- (2015) Kazuhiro Tanaka et al. JOURNAL OF CLINICAL INVESTIGATION
- Immunohistochemical profiles of IDH1, MGMT and P53: Practical significance for prognostication of patients with diffuse gliomas
- (2015) Ryosuke Ogura et al. NEUROPATHOLOGY
- Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax
- (2015) R Bajpai et al. ONCOGENE
- Gankyrin facilitates follicle-stimulating hormone-driven ovarian cancer cell proliferation through the PI3K/AKT/HIF-1α/cyclin D1 pathway
- (2015) J Chen et al. ONCOGENE
- HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase
- (2015) Jayasri Nanduri et al. PLoS One
- ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate
- (2015) Melissa M. Keenan et al. PLoS Genetics
- IDH1 Overexpression Induced Chemotherapy Resistance and IDH1 Mutation Enhanced Chemotherapy Sensitivity in Glioma Cells in Vitro and in Vivo
- (2014) Ju-Bo Wang et al. Asian Pacific Journal of Cancer Prevention
- Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents
- (2014) Minh Truong Do et al. FREE RADICAL BIOLOGY AND MEDICINE
- Benefit From Procarbazine, Lomustine, and Vincristine in Oligodendroglial Tumors Is Associated With Mutation ofIDH
- (2014) J. Gregory Cairncross et al. JOURNAL OF CLINICAL ONCOLOGY
- The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
- (2014) Randall M. Chin et al. NATURE
- Isocitrate Dehydrogenase 1 Is a Novel Plasma Biomarker for the Diagnosis of Non-Small Cell Lung Cancer
- (2013) N. Sun et al. CLINICAL CANCER RESEARCH
- FSH enhances the proliferation of ovarian cancer cells by activating transient receptor potential channel C3
- (2013) Xiang Tao et al. ENDOCRINE-RELATED CANCER
- The clinicopathologic significance of p53 and BAF-250a (ARID1A) expression in clear cell carcinoma of the endometrium
- (2013) Oluwole Fadare et al. MODERN PATHOLOGY
- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways
- (2012) Zhenbo Zhang et al. CANCER LETTERS
- Aberrant upregulation ofASCL2by promoter demethylation promotes the growth and resistance to 5-fluorouracil of gastric cancer cells
- (2012) Oh-Hyung Kwon et al. CANCER SCIENCE
- Detection of PAX8 and p53 is beneficial in recognizing metastatic carcinomas in pelvic washings, especially in cases with suspicious cytology
- (2012) Li Xiang et al. GYNECOLOGIC ONCOLOGY
- Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway
- (2012) Rabbie K. Hanna et al. GYNECOLOGIC ONCOLOGY
- Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expression
- (2012) Lingling Dong et al. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
- Endometrial Cancer
- (2012) Joel I. Sorosky OBSTETRICS AND GYNECOLOGY
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- A Mutation Threshold Distinguishes the Antitumorigenic Effects of the Mitochondrial Gene MTND1, an Oncojanus Function
- (2011) G. Gasparre et al. CANCER RESEARCH
- IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma
- (2011) Qi SongTao et al. CANCER SCIENCE
- Metformin Reverses Progestin Resistance in Endometrial Cancer Cells by Downregulating GloI Expression
- (2011) Zhenbo Zhang et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer
- (2010) T. Jiang et al. CANCER RESEARCH
- Metformin Treatment Exerts Antiinvasive and Antimetastatic Effects in Human Endometrial Carcinoma Cells
- (2010) Bee K. Tan et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- The expression and significance of IDH1 and p53 in osteosarcoma
- (2010) Xiang Hu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth
- (2010) P. Zhang et al. MOLECULAR CANCER THERAPEUTICS
- IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas
- (2010) C. Houillier et al. NEUROLOGY
- Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds
- (2009) A.Kenneth MacLeod et al. CARCINOGENESIS
- Resistance to chemotherapy and hormone therapy in endometrial cancer
- (2009) Parvesh Chaudhry et al. ENDOCRINE-RELATED CANCER
- Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway
- (2009) Gi-seong Shim et al. FREE RADICAL BIOLOGY AND MEDICINE
- Metformin in Breast Cancer: Time for Action
- (2009) Pamela J. Goodwin et al. JOURNAL OF CLINICAL ONCOLOGY
- Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
- (2009) Yoo Ri Kim et al. JOURNAL OF PATHOLOGY
- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
- (2009) M. Tahiliani et al. SCIENCE
- Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth
- (2008) T. Ohta et al. CANCER RESEARCH
- RNAi-Mediated Silencing of Nuclear Factor Erythroid-2-Related Factor 2 Gene Expression in Non-Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy
- (2008) A. Singh et al. CANCER RESEARCH
- Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
- (2008) X.-J. Wang et al. CARCINOGENESIS
- Endometrial Glandular Dysplasia with Frequent p53 Gene Mutation: A Genetic Evidence Supporting Its Precancer Nature for Endometrial Serous Carcinoma
- (2008) L. Jia et al. CLINICAL CANCER RESEARCH
- Dietary Cancer Chemopreventive Agents – Targeting Inflammation and Nrf2 Signaling Pathway
- (2008) Tin Khor et al. PLANTA MEDICA
- Metformin induces apoptosis of pancreatic cancer cells
- (2008) Luo-Wei Wang et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to cancer cell resistance
- (2007) Jeong-Min Cho et al. CANCER LETTERS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started