Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

(2010) Ken Itoh et al.   ANTIOXIDANTS & REDOX SIGNALING

High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer

(2010) T. Jiang et al.   CANCER RESEARCH

Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features

(2010) L. M. Solis et al.   CLINICAL CANCER RESEARCH

Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

(2010) P. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates Drug Resistance in Pancreatic Cancer Cells

(2010) Young Bin Hong et al.   PANCREAS

Nrf2: friend or foe for chemoprevention?

(2009) T. W. Kensler et al.   CARCINOGENESIS

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

(2009) S. Homma et al.   CLINICAL CANCER RESEARCH

Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway

(2009) Gi-seong Shim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

(2009) Yoo Ri Kim et al.   JOURNAL OF PATHOLOGY

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer

(2008) T. O. Khor et al.   Cancer Prevention Research

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

RNAi-Mediated Silencing of Nuclear Factor Erythroid-2-Related Factor 2 Gene Expression in Non-Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy

(2008) A. Singh et al.   CANCER RESEARCH

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Oridonin Confers Protection against Arsenic-Induced Toxicity through Activation of the Nrf2-Mediated Defensive Response

(2008) Yu Du et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The cancer chemopreventive actions of phytochemicals derived from glucosinolates

(2008) John D. Hayes et al.   EUROPEAN JOURNAL OF NUTRITION

Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells

(2008) Sang Kyum Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dual roles of Nrf2 in cancer

(2008) A LAU et al.   PHARMACOLOGICAL RESEARCH

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to cancer cell resistance

(2007) Jeong-Min Cho et al.   CANCER LETTERS