Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells

FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism

(2015)   Oncotarget

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1

(2015) Sally-Anne Heasman et al.   Oncotarget

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

RXR  Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

(2013) H. Wang et al.   CANCER RESEARCH

Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies

(2013) Julien Ablain et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner

(2013) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Arsenic Trioxide Prevents Osteosarcoma Growth by Inhibition of GLI Transcription via DNA Damage Accumulation

(2013) Shunsuke Nakamura et al.   PLoS One

Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy

(2012) E. Chendamarai et al.   BLOOD

ATRA plus arsenic gets another "A" in APL

(2012) J. H. Park   BLOOD

All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4)

(2012) H. J. Iland et al.   BLOOD

The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling

(2012) E. Lang et al.   BLOOD

Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment

(2011) E. Goto et al.   BLOOD

Genome-wide functions of PML–RARα in acute promyelocytic leukaemia

(2011) S Saeed et al.   BRITISH JOURNAL OF CANCER

Phase 1 study of arsenic trioxide, high-dose cytarabine, and idarubicin to down-regulate constitutive signal transducer and activator of transcription 3 activity in patients aged

(2011) Meir Wetzler et al.   CANCER

A randomized phase 2 trial of a preparative regimen of bortezomib, high-dose melphalan, arsenic trioxide, and ascorbic acid

(2011) Manish Sharma et al.   CANCER

Advances in therapies for acute promyelocytic leukemia

(2011) Tomohiko Kamimura et al.   CANCER SCIENCE

Lipoic acid ameliorates arsenic trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages

(2011) Lisu Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Securinine, a Myeloid Differentiation Agent with Therapeutic Potential for AML

(2011) Kalpana Gupta et al.   PLoS One

The Role of Nrf2 and Cytoprotection in Regulating Chemotherapy Resistance of Human Leukemia Cells

(2011) Stuart A. Rushworth et al.   Cancers

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

A Phase 2 study of combination therapy with arsenic trioxide and gemtuzumab ozogamicin in patients with myelodysplastic syndromes or secondary acute myeloid leukemia

(2010) Mikkael A. Sekeres et al.   CANCER

Helicobacter pylori–Induced Loss of the Inhibitor‐of‐Apoptosis Protein Survivin Is Linked to Gastritis and Death of Human Gastric Cells

(2010) Manuel Valenzuela et al.   JOURNAL OF INFECTIOUS DISEASES

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

How I treat acute promyelocytic leukemia

(2009) M. S. Tallman et al.   BLOOD

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

(2009) J. W. Vardiman et al.   BLOOD

Reactive Oxygen Species Are Not Required for an Arsenic Trioxide-induced Antioxidant Response or Apoptosis

(2009) Alejo A. Morales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Retinoic acid syndrome: a review

(2008) E. Patatanian et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS