Oxidative stress and lipotoxicity

Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice

(2016) Colin T. Shearn et al.   Redox Biology

Role of 4-Hydroxynonenal-Protein Adducts in Human Diseases

(2015) Giuseppina Barrera et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of antioxidants in the chemistry of oxidative stress: A review

(2015) Aurelia Magdalena Pisoschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of an unstable 4-hydroxynoneal modification on the 20S proteasome subunit α7 by recombinant antibody technology.

(2015) Jesper Just et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inflammation and ER Stress Regulate Branched-Chain Amino Acid Uptake and Metabolism in Adipocytes

(2015) Joel S. Burrill et al.   MOLECULAR ENDOCRINOLOGY

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

(2015) Lalage A. Katunga et al.   Molecular Metabolism

Oxidative proteome alterations during skeletal muscle ageing

(2015) Sofia Lourenço dos Santos et al.   Redox Biology

Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria

(2015) Huiqin Zhong et al.   Redox Biology

Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment

(2014) Y. Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function

(2014) James J. Galligan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipidomic analysis of molecular cardiolipin species in livers exposed to ischemia/reperfusion

(2014) Jan-Christian Martens et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Proteomic analysis of 4-hydroxynonenal (4-HNE) modified proteins in liver mitochondria from chronic ethanol-fed rats

(2014) Kelly K. Andringa et al.   Redox Biology

Formation of electrophilic oxidation products from mitochondrial cardiolipin in vitro and in vivo in the context of apoptosis and atherosclerosis

(2014) Huiqin Zhong et al.   Redox Biology

Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity

(2013) Denise E. Lackey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Functional role of cardiolipin in mitochondrial bioenergetics

(2013) Giuseppe Paradies et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ALDH2 protects against stroke by clearing 4-HNE

(2013) Jin-Min Guo et al.   CELL RESEARCH

Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes

(2013) Eugenia Mileykovskaya et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism

(2013) Faidon Magkos et al.   DIABETES

High-fat diet induces changes in adipose tissue trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels in a depot-specific manner

(2013) Eric K. Long et al.   FREE RADICAL BIOLOGY AND MEDICINE

Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness

(2013) Bryan C. Batch et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Oxidized lipids activate autophagy in a JNK-dependent manner by stimulating the endoplasmic reticulum stress response

(2013) Petra Haberzettl et al.   Redox Biology

Protein Carbonylation in a Murine Model for Early Alcoholic Liver Disease

(2012) James J. Galligan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Lipid Peroxidation Product 4-Hydroxy-trans-2-nonenal Causes Endothelial Activation by Inducing Endoplasmic Reticulum Stress

(2012) Elena Vladykovskaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Carbonylation and Adipocyte Mitochondrial Function

(2012) Jessica M. Curtis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Exercise Training Restores Cardiac Protein Quality Control in Heart Failure

(2012) Juliane C. Campos et al.   PLoS One

Cigarette smoke-induced oxidative stress in skeletal muscles of mice

(2012) Esther Barreiro et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Protein carbonylation and metabolic control systems

(2012) Jessica M. Curtis et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease

(2011) Rebecca L. Smathers et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Permeabilization of the Mitochondrial Outer Membrane by Bax/Truncated Bid (tBid) Proteins as Sensitized by Cardiolipin Hydroperoxide Translocation

(2011) Witold Korytowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria

(2011) Jia Guo et al.   Journal of Proteomics

Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction

(2011) Juan D. Chavez et al.   Journal of Proteomics

Proteomic profiling of acrolein adducts in human lung epithelial cells

(2011) Page C. Spiess et al.   Journal of Proteomics

Quantitative Proteomic Profiling of Muscle Type-Dependent and Age-Dependent Protein Carbonylation in Rat Skeletal Muscle Mitochondria

(2011) J. Feng et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Increased Oxidative Damage and Decreased Antioxidant Function in Aging Human Substantia Nigra Compared to Striatum: Implications for Parkinson’s Disease

(2011) C. Venkateshappa et al.   NEUROCHEMICAL RESEARCH

Increased Adipose Protein Carbonylation in Human Obesity

(2011) Brigitte I. Frohnert et al.   Obesity

Malondialdehyde (MDA) and protein carbonyl (PCO) levels as biomarkers of oxidative stress in subjects with familial hypercholesterolemia

(2010) Ayfer Gözü Pirinccioglu et al.   CLINICAL BIOCHEMISTRY

Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction

(2010) J. M. Curtis et al.   DIABETES

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition

(2010) Wei Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Profiling Carbonylated Proteins in Human Plasma

(2010) Ashraf G. Madian et al.   JOURNAL OF PROTEOME RESEARCH

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

How does the Bax-α1 targeting sequence interact with mitochondrial membranes? The role of cardiolipin

(2009) Marc-Antoine Sani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and disease

(2009) Giuseppe Paradies et al.   CELL CALCIUM

Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

(2009) Sung Hoon Back et al.   Cell Metabolism

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Bax inhibitor 1 regulates ER-stress-induced ROS accumulation through the regulation of cytochrome P450 2E1

(2009) H.-R. Kim et al.   JOURNAL OF CELL SCIENCE

Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart

(2009) Ethan J. Anderson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis

(2008) Jianfei Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells

(2008) Bradford G. Hill et al.   BIOCHEMICAL JOURNAL

Role of the Electrophilic Lipid Peroxidation Product 4-Hydroxynonenal in the Development and Maintenance of Obesity in Mice†

(2008) Sharda P. Singh et al.   BIOCHEMISTRY

Oxidized Low-Density Lipoproteins Trigger Endoplasmic Reticulum Stress in Vascular Cells

(2008) Marie Sanson et al.   CIRCULATION RESEARCH

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of endoplasmic reticulum stress in acrolein-induced endothelial activation

(2008) Petra Haberzettl et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY