Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer

Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms: Association with poor prognosis in head and neck cancer

(2014) Victor D. Martinez et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination

(2013) B. E. Hast et al.   CANCER RESEARCH

Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

(2013) Toshiaki Fukutomi et al.   MOLECULAR AND CELLULAR BIOLOGY

Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer

(2013) Victor D Martinez et al.   Molecular Cancer

Mechanisms and function of substrate recruitment by F-box proteins

(2013) Jeffrey R. Skaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reactive oxygen species regulate FSH-induced expression of vascular endothelial growth factor via Nrf2 and HIF1α signaling in human epithelial ovarian cancer

(2013) ZHENBO ZHANG et al.   ONCOLOGY REPORTS

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

(2013) L. Baird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

(2012) Roel G.W. Verhaak et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers

(2012) T Yamadori et al.   ONCOGENE

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones

(2012) Youji Feng   ONCOLOGY REPORTS

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

(2012) Yoichiro Mitsuishi et al.   Frontiers in Oncology

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

(2011) P. A. Konstantinopoulos et al.   CANCER RESEARCH

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Genetic Disruption of KEAP1/CUL3 E3 Ubiquitin Ligase Complex Components is a Key Mechanism of NF-KappaB Pathway Activation in Lung Cancer

(2011) Kelsie L. Thu et al.   Journal of Thoracic Oncology

Predicting the functional impact of protein mutations: application to cancer genomics

(2011) Boris Reva et al.   NUCLEIC ACIDS RESEARCH

Reactive oxygen species are indispensable in ovulation

(2011) K. Shkolnik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

Oxidative Stress

(2010) Sylvie Poncin et al.   AMERICAN JOURNAL OF PATHOLOGY

Nrf2: friend or foe for chemoprevention?

(2009) T. W. Kensler et al.   CARCINOGENESIS

Minimal oxidative load: a prerequisite for thyroid cell function

(2009) Sylvie Poncin et al.   JOURNAL OF ENDOCRINOLOGY

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

(2009) Yoo Ri Kim et al.   JOURNAL OF PATHOLOGY

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

(2008) Tatsuhiro Shibata et al.   GASTROENTEROLOGY

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA