The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders

Association of glucocerebrosidase polymorphisms and mutations with dementia in incident Parkinson's disease

(2018) Kristin Aaser Lunde et al.   Alzheimers & Dementia

Trio approach reveals higher risk of PD in carriers of severe vs. mild GBA mutations

(2018) David Arkadir et al.   BLOOD CELLS MOLECULES AND DISEASES

Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis

(2018) Mariah L Hoye et al.   BRAIN

Up-regulated Pro-inflammatory MicroRNAs (miRNAs) in Alzheimer’s disease (AD) and Age-Related Macular Degeneration (AMD)

(2018) Aileen I. Pogue et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Forkhead Transcription Factors: Formulating a FOXO Target for Cognitive Loss

(2018) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

Sphingolipids in host–microbial interactions

(2018) Stacey L Heaver et al.   CURRENT OPINION IN MICROBIOLOGY

Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F

(2018) Nicholas U. Schwartz et al.   FASEB JOURNAL

Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson’s disease

(2018) Vassilis E Papadopoulos et al.   HUMAN MOLECULAR GENETICS

Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood–brain barrier integrity and exerts therapeutic effect in an animal model of Huntington’s disease

(2018) Alba Di Pardo et al.   HUMAN MOLECULAR GENETICS

Skeletal Muscle MicroRNAs as Key Players in the Pathogenesis of Amyotrophic Lateral Sclerosis

(2018) Lorena Di Pietro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Age-Dependent Changes to Sphingolipid Balance in the Human Hippocampus are Gender-Specific and May Sensitize to Neurodegeneration

(2018) Timothy A. Couttas et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular α-synuclein drives sphingosine 1-phosphate receptor subtype 1 out of lipid rafts, leading to impaired inhibitory G-protein signaling

(2018) Shaymaa Mohamed Mohamed Badawy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NFκB signalling

(2018) Yin-Feng Dong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Subventricular Zone Lipidomic Architecture Loss in Huntington's Disease

(2018) Mandana Hunter et al.   JOURNAL OF NEUROCHEMISTRY

Targeting HDAC3 Activity with RGFP966 Protects Against Retinal Ganglion Cell Nuclear Atrophy and Apoptosis After Optic Nerve Injury

(2018) Heather M. Schmitt et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington's disease model

(2018) Regina Hertfelder Reynolds et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Bacteroidetes Neurotoxins and Inflammatory Neurodegeneration

(2018) Yuhai Zhao et al.   MOLECULAR NEUROBIOLOGY

Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer’s Disease

(2018) Henryk Jęśko et al.   MOLECULAR NEUROBIOLOGY

Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal

(2018) Shi Zhang et al.   NEUROBIOLOGY OF AGING

Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase

(2018) Joanna Motyl et al.   NEUROPHARMACOLOGY

A novel p.L216I mutation in the glucocerebrosidase gene is associated with Parkinson’s disease in Han Chinese patients

(2018) Hong Jin et al.   NEUROSCIENCE LETTERS

Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neuronal diseases. The promising target for neuroprotection in Parkinson’s disease

(2018) Joanna Motyl et al.   Pharmacological Reports

MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice

(2018) Peter Langfelder et al.   PLoS One

Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium

(2018) Seung-Hyun Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The S1P Axis: New Exciting Route for Treating Huntington’s Disease

(2018) Alba Di Pardo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sphingolipid Metabolism Is Dysregulated at Transcriptomic and Metabolic Levels in the Spinal Cord of an Animal Model of Amyotrophic Lateral Sclerosis

(2018) Alexandre Henriques et al.   Frontiers in Molecular Neuroscience

Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity

(2018) Salema B. Abul Khair et al.   Frontiers in Neuroscience

Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain

(2018) Gaëlle Dominguez et al.   Acta Neuropathologica Communications

Fingolimod (FTY720) is not protective in the subacute MPTP mouse model of Parkinson disease and does not lead to a sustainable increase of brain BDNF

(2018) Daniel Komnig et al.   JOURNAL OF NEUROCHEMISTRY

The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration

(2018) Henryk Jęśko et al.   MOLECULAR NEUROBIOLOGY

Dysregulation of MicroRNAs and Target Genes Networks in Peripheral Blood of Patients With Sporadic Amyotrophic Lateral Sclerosis

(2018) Maria Liguori et al.   Frontiers in Molecular Neuroscience

Localization of RNAi Machinery to Axonal Branch Points and Growth Cones Is Facilitated by Mitochondria and Is Disrupted in ALS

(2018) Noga Gershoni-Emek et al.   Frontiers in Molecular Neuroscience

Wide-Ranging Analysis of MicroRNA Profiles in Sporadic Amyotrophic Lateral Sclerosis Using Next-Generation Sequencing

(2018) Bruna De Felice et al.   Frontiers in Genetics

Bioactive Phospholipids Enhance Migration and Adhesion of Human Leukemic Cells by Inhibiting Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS) in a p38 MAPK-Dependent Manner

(2018) Ahmed Abdelbaset-Ismail et al.   Stem Cell Reviews and Reports

Neuroprotective effects of fingolimod in mouse models of Parkinson’s disease

(2017) Peng Zhao et al.   FASEB JOURNAL

Sphingolipid-Enriched Extracellular Vesicles and Alzheimer’s Disease: A Decade of Research

(2017) Michael B. Dinkins et al.   JOURNAL OF ALZHEIMERS DISEASE

Involvement of Gβγ subunits of Giprotein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes

(2017) Taketoshi Kajimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal defects in ATP13A2 and GBA associated familial Parkinson’s disease

(2017) Shigeto Sato et al.   JOURNAL OF NEURAL TRANSMISSION

Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease

(2017) Yumiko V. Taguchi et al.   JOURNAL OF NEUROSCIENCE

IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function

(2017) Joaquín Pardo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Cerebrospinal fluid β-glucocerebrosidase activity is reduced in parkinson's disease patients

(2017) Lucilla Parnetti et al.   MOVEMENT DISORDERS

Cognitive decline in Parkinson disease

(2017) Dag Aarsland et al.   Nature Reviews Neurology

MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study

(2017) Eric R. Reed et al.   NEUROLOGY

Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases

(2017) Sinead O'Sullivan et al.   NEUROPHARMACOLOGY

Oligomeric α-synuclein and glucocerebrosidase activity levels in GBA-associated Parkinson’s disease

(2017) S. Pchelina et al.   NEUROSCIENCE LETTERS

Ceramide and Its Related Neurochemical Networks as Targets for Some Brain Disorder Therapies

(2017) Justyna Brodowicz et al.   NEUROTOXICITY RESEARCH

Disease manifestations and burden of illness in patients with acid sphingomyelinase deficiency (ASMD)

(2017) Margaret M. McGovern et al.   Orphanet Journal of Rare Diseases

SMPD1 variants in Chinese Han patients with sporadic Parkinson's disease

(2017) Cheng-yuan Mao et al.   PARKINSONISM & RELATED DISORDERS

Serum lipid alterations in GBA -associated Parkinson's disease

(2017) Leonor Correia Guedes et al.   PARKINSONISM & RELATED DISORDERS

Comprehensive identification of age-related lipidome changes in rat amygdala during normal aging

(2017) Roman Šmidák et al.   PLoS One

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements

(2017) Leila Pirhaji et al.   Nature Communications

Sphingolipids: membrane microdomains in brain development, function and neurological diseases

(2017) Anne S. B. Olsen et al.   Open Biology

Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease

(2017) Lijuan Zhang et al.   MEDICAL SCIENCE MONITOR

De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease

(2017) Alba Di Pardo et al.   Frontiers in Neuroscience

Exosomes as Carriers of Alzheimer's Amyloid-ß

(2017) Kohei Yuyama et al.   Frontiers in Neuroscience

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

(2017) Jennifer Ngolab et al.   Acta Neuropathologica Communications

Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons

(2017) Pooja Joshi et al.   Scientific Reports

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease

(2017) Alba Di Pardo et al.   Scientific Reports

GM1 Ganglioside Inhibits β-Amyloid Oligomerization Induced by Sphingomyelin

(2016) Mariana Amaro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

LRRK2 deficiency impacts ceramide metabolism in brain

(2016) Ruggero Ferrazza et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glycoblotting method allows for rapid and efficient glycome profiling of human Alzheimer's disease brain, serum and cerebrospinal fluid towards potential biomarker discovery

(2016) Solomon T. Gizaw et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Exocytosis and Spreading of Normal and Aberrant α-Synuclein

(2016) Evangelia Emmanouilidou et al.   BRAIN PATHOLOGY

Expression of microRNA-34a in Alzheimer's disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity

(2016) S. Sarkar et al.   BRAIN RESEARCH

Treatments and compositions targeting α-synuclein: a patent review (2010-2016)

(2016) Henryk Jęśko et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Progress and potential of non-inhibitory small molecule chaperones for the treatment of Gaucher disease and its implications for Parkinson disease

(2016) Olive Jung et al.   Expert Review of Proteomics

Sphingosine 1-phosphate in metabolic syndrome (Review)

(2016) Wei Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

An overview of circulating cell-free microRNAs as putative biomarkers in Alzheimer's and Parkinson's Diseases

(2016) Meire Silva Batistela et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Ceramide channels and mitochondrial outer membrane permeability

(2016) Marco Colombini   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice

(2016) Guadalupe Vidal-Martínez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis

(2016) Dan Ploug Christensen et al.   Journal of Neuroinflammation

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

Associations between plasma ceramides and cognitive and neuropsychiatric manifestations in Parkinson's disease dementia

(2016) Yi Xing et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neuropsychiatric characteristics of GBA-associated Parkinson disease

(2016) Matthew Swan et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans

(2016) Mariona Jové et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Revealing disease-associated pathways by network integration of untargeted metabolomics

(2016) Leila Pirhaji et al.   NATURE METHODS

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease

(2016) Timothy A. Couttas et al.   NEUROBIOLOGY OF AGING

FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models

(2016) Manru Ren et al.   NEUROCHEMICAL RESEARCH

Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis

(2016) Rosa Luisa Potenza et al.   Neurotherapeutics

Regulation of sphingomyelin metabolism

(2016) Kamil Bienias et al.   Pharmacological Reports

Integrated sphingosine-1 phosphate signaling in the central nervous system: From physiological equilibrium to pathological damage

(2016) Rasoul Ghasemi et al.   PHARMACOLOGICAL RESEARCH

Circulating microRNAs in Huntington’s disease: Emerging mediators in metabolic impairment

(2016) C. Díez-Planelles et al.   PHARMACOLOGICAL RESEARCH

GBA Variants Influence Motor and Non-Motor Features of Parkinson’s Disease

(2016) Silvia Jesús et al.   PLoS One

Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency

(2016) Stefka D. Spassieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response

(2016) Ruijuan Xu et al.   Oncotarget

Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells

(2016) Mi-Hyeon Jeong et al.   Oncotarget

Amyloidβ Peptides in interaction with raft-mime model membranes: a neutron reflectivity insight

(2016) Valeria Rondelli et al.   Scientific Reports

The somatotropic axis and longevity in mice

(2015) H. M. Brown-Borg   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity

(2015) Nobumasa Takasugi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential regulation of autophagy and cell viability by ceramide species

(2015) Nichola Cruickshanks et al.   CANCER BIOLOGY & THERAPY

Growth factor treatment to overcome Alzheimer's dysfunctional signaling

(2015) Marc-Antoine Lauzon et al.   CELLULAR SIGNALLING

P.5.c.002 Sphingosine kinase 1 mediated signalling in Parkinson's disease animal model. Neuroprotective effect of fingolimod and a D2/D3 dopamine receptor agonist

(2015) J. Moty et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase

(2015) Alexandre Henriques et al.   HUMAN MOLECULAR GENETICS

Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTRup-regulation and astrocyte-mediated inflammation

(2015) Andrés Miguez et al.   HUMAN MOLECULAR GENETICS

Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils

(2015) Max Eberle et al.   IMMUNOLOGY AND CELL BIOLOGY

Expression of Functional Sphingosine-1 Phosphate Receptor-1 Is Reduced by B Cell Receptor Signaling and Increased by Inhibition of PI3 Kinase δ but Not SYK or BTK in Chronic Lymphocytic Leukemia Cells

(2015) Kathleen J. Till et al.   JOURNAL OF IMMUNOLOGY

miR-155 Deficiency Ameliorates Autoimmune Inflammation of Systemic Lupus Erythematosus by TargetingS1pr1inFaslpr/lprMice

(2015) Qian Xin et al.   JOURNAL OF IMMUNOLOGY

Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs

(2015) Amanda L. Aloia et al.   MEDIATORS OF INFLAMMATION

Systematic Genetic Analysis of the SMPD1 Gene in Chinese Patients with Parkinson’s Disease

(2015) Sheng Deng et al.   MOLECULAR NEUROBIOLOGY

Study of plasma-derived miRNAs mimic differences in Huntington's disease brain

(2015) Andrew G. Hoss et al.   MOVEMENT DISORDERS

Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation

(2015) Yixuan Wang et al.   NEUROBIOLOGY OF AGING

Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosis

(2015) J. Kuhle et al.   NEUROLOGY

Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson’s disease and in MPP+-treated MN9D cells in vitro

(2015) M. Sivasubramanian et al.   NEUROSCIENCE

The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease

(2015) Zhenzhen Liu et al.   Oxidative Medicine and Cellular Longevity

Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and AβAccumulation

(2015) Maja Jazvinšćak Jembrek et al.   Oxidative Medicine and Cellular Longevity

The contribution of Niemann-Pick SMPD1 mutations to Parkinson disease in Ashkenazi Jews

(2015) E. Dagan et al.   PARKINSONISM & RELATED DISORDERS

The emerging role of SMPD1 mutations in Parkinson's disease: Implications for future studies

(2015) Ziv Gan-Or et al.   PARKINSONISM & RELATED DISORDERS

Maternal Plasma and Amniotic Fluid Sphingolipids Profiling in Fetal Down Syndrome

(2015) Karol Charkiewicz et al.   PLoS One

Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis

(2015) James C. Dodge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

(2015) YaXing Gui et al.   Oncotarget

Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain

(2015) Kai Wang et al.   PLoS Genetics

Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation

(2015) Io-Guané Rivera et al.   Toxins

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging

(2014) Michelle M. Mielke et al.   AGING CELL

Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells

(2014) Marthe-Susanna Wegner et al.   BIOCHEMICAL PHARMACOLOGY

Original article Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein

(2014) Henryk Jesko et al.   FOLIA NEUROPATHOLOGICA

Original article The key role of sphingosine kinases in the molecular mechanism of neuronal cell survival and death in an experimental model of Parkinson’s disease

(2014) Joanna A. Pyszko et al.   FOLIA NEUROPATHOLOGICA

Sphingolipids: Key Regulators of Apoptosis and Pivotal Players in Cancer Drug Resistance

(2014) Paola Giussani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein

(2014) Ilker Karaca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LDL Receptor and ApoE Are Involved in the Clearance of ApoM-associated Sphingosine 1-Phosphate

(2014) Makoto Kurano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-Phosphate Mediates COX-2 Expression and PGE2/IL-6 Secretion via c-Src-Dependent AP-1 Activation

(2014) Chih-Kai Hsu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of S1P1 Receptor Regulates PI3K/Akt/FoxO3a Pathway in Response to Oxidative Stress in PC12 Cells

(2014) Fatemeh Safarian et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans

(2014) Roy G. Cutler et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Sphingosine Kinase 1 and Sphingosine-1-Phosphate in Oxidative Stress Evoked by 1-Methyl-4-Phenylpyridinium (MPP+) in Human Dopaminergic Neuronal Cells

(2014) Joanna Pyszko et al.   MOLECULAR NEUROBIOLOGY

Ceramide in the Molecular Mechanisms of Neuronal Cell Death. The Role of Sphingosine-1-Phosphate

(2014) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

Sphingosine-1-Phosphate and Its Effect on Glucose Deprivation/Glucose Reload Stress: From Gene Expression to Neuronal Survival

(2014) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Ceramides and sphingomyelinases in senile plaques

(2014) Maï Panchal et al.   NEUROBIOLOGY OF DISEASE

Sphingosine Kinases/Sphingosine-1-Phosphate and Death Signalling in APP-Transfected Cells

(2014) Magdalena Gassowska et al.   NEUROCHEMICAL RESEARCH

Fingolimod for the treatment of neurological diseases—state of play and future perspectives

(2014) Robert Brunkhorst et al.   Frontiers in Cellular Neuroscience

Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy

(2014) Masayuki Nagahashi et al.   Biomed Research International

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

(2014) Timothy A Couttas et al.   Acta Neuropathologica Communications

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease

(2014) Johnatan Ceccom et al.   Acta Neuropathologica Communications

Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease

(2013) Kohei Yuyama et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingolipids and lifespan regulation

(2013) Xinhe Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Autophagy paradox and ceramide

(2013) Wenhui Jiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ceramide and the mitochondrial respiratory chain

(2013) Aviram Kogot-Levin et al.   BIOCHIMIE

AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose

(2013) Kaipeng Huang et al.   CELLULAR SIGNALLING

FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease

(2013) Alba Di Pardo et al.   HUMAN MOLECULAR GENETICS

Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice

(2013) Hong Cui et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Modulation of Lipid Kinase PI4KIIα Activity and Lipid Raft Association of Presenilin 1 Underlies γ-Secretase Inhibition by Ginsenoside (20S)-Rg3

(2013) Min Suk Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion

(2013) Patrick Ejlerskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats

(2013) Masoumeh Asle-Rousta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson's disease

(2013) Sarah K. Abbott et al.   MOVEMENT DISORDERS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease

(2013) Hirosha Geekiyanage et al.   NEUROBIOLOGY OF AGING

A rare lysosomal enzyme gene SMPD1 variant (p.R591C) associates with Parkinson's disease

(2013) Jia-Nee Foo et al.   NEUROBIOLOGY OF AGING

FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons

(2013) Nobumasa Takasugi et al.   PLoS One

Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive Impairment: A Pilot Study

(2013) Michelle M. Mielke et al.   PLoS One

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

(2013) C Rutherford et al.   Cell Death & Disease

Lysophospholipids and their receptors in the central nervous system

(2012) Ji Woong Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ceramide function in the brain: when a slight tilt is enough

(2012) Chiara Mencarelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death

(2012) James R. Van Brocklyn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

(2012) Guanghu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutral Sphingomyelinase 2 Deficiency Increases Hyaluronan Synthesis by Up-regulation of Hyaluronan Synthase 2 through Decreased Ceramide Production and Activation of Akt

(2012) Jingdong Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-dependent secretion of alpha-synuclein by enteric neurons

(2012) Sébastien Paillusson et al.   JOURNAL OF NEUROCHEMISTRY

Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice

(2012) Mei-Hong Lu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons

(2012) Terina N Martinez et al.   Molecular Neurodegeneration

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease

(2012) M. Kosicek et al.   NEUROSCIENCE LETTERS

ASM-3 Acid Sphingomyelinase Functions as a Positive Regulator of the DAF-2/AGE-1 Signaling Pathway and Serves as a Novel Anti-Aging Target

(2012) Yongsoon Kim et al.   PLoS One

Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin-like growth factor-1-induced myoblast differentiation

(2012) Caterina Bernacchioni et al.   Skeletal Muscle

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

(2011) Joris Deelen et al.   AGE

AP-1 binding transcriptionally regulates human neutral ceramidase

(2011) Sean M. O’Neill et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism

(2011) N Hagen et al.   CELL DEATH AND DIFFERENTIATION

Sphingolipid signaling and neuronal function

(2011) Shun-ichi Nakamura et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells

(2011) Gabriella Marfe et al.   EXPERIMENTAL HEMATOLOGY

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

(2011) N. Takasugi et al.   JOURNAL OF NEUROSCIENCE

Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells

(2011) Yuan Yuan Li et al.   NEUROSCIENCE LETTERS

Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1

(2011) Colin Selman et al.   PLoS One

The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein

(2011) Takafumi Hasegawa et al.   PLoS One

Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?

(2011) Alex F. Bokov et al.   PLoS One

A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

(2011) Lihong Zhao et al.   PLoS Genetics

Mutations in the SPTLC2 Subunit of Serine Palmitoyltransferase Cause Hereditary Sensory and Autonomic Neuropathy Type I

(2010) Annelies Rotthier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease

(2010) Xianlin Han   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid mediators in the nucleus: Their potential contribution to Alzheimer's disease

(2010) Akhlaq A. Farooqui et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage

(2010) Andrea Huwiler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity

(2010) Qiong Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells

(2010) Judith Mesicek et al.   CELLULAR SIGNALLING

Plasma membrane microdomains in aging and disease

(2010) Yoshiko Ohno-Iwashita et al.   Geriatrics & Gerontology International

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Alterations of the Sphingolipid Pathway in Alzheimer’s Disease: New Biomarkers and Treatment Targets?

(2010) Michelle M. Mielke et al.   NEUROMOLECULAR MEDICINE

The interaction of beta-amyloid protein with cellular membranes stimulates its own production

(2009) Imke Peters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages

(2009) María H. Granado et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ERK and cell death: ERK1/2 in neuronal death

(2009) Srinivasa Subramaniam et al.   FEBS Journal

The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

(2009) A. N. Packer et al.   JOURNAL OF NEUROSCIENCE

Translational regulation mechanisms of AP-1 proteins

(2009) Paul Willi Vesely et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex

(2009) Prerna Sethi et al.   NEUROSCIENCE LETTERS

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats

(2009) Yu Hasegawa et al.   STROKE

Ceramide 1-phosphate (C1P) promotes cell migration

(2008) María H. Granado et al.   CELLULAR SIGNALLING

Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease

(2008) Jose Bras et al.   FEBS Journal

Phosphatidylinositol 3-Kinase/AKT Pathway Regulates the Endoplasmic Reticulum to Golgi Traffic of Ceramide in Glioma Cells

(2008) Paola Giussani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke

(2008) Nik Sawe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

(2008) Laurent Kappeler et al.   PLOS BIOLOGY

Ceramide 1-phosphate stimulates macrophage proliferation through activation of the PI3-kinase/PKB, JNK and ERK1/2 pathways

(2007) Patricia Gangoiti et al.   CELLULAR SIGNALLING

ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain

(2007) Veera Venkata Ratnam Bandaru et al.   NEUROBIOLOGY OF AGING