Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein

Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer’s Disease

(2013) Marcus Grimm et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cross-talk of membrane lipids and Alzheimer-related proteins

(2013) Jochen Walter et al.   Molecular Neurodegeneration

Evidence for a link between histone deacetylation and Ca2+homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts

(2012) Katja Ihlefeld et al.   BIOCHEMICAL JOURNAL

Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase

(2012) Oliver Holmes et al.   BIOCHEMISTRY

Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells

(2012) Martina Malnar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The intracellular Ca2+channels of membrane traffic

(2012) Kirill K. Kiselyov et al.   Channels

Sphingosine 1-Phosphate (S1P) Lyase Deficiency Increases Sphingolipid Formation via Recycling at the Expense ofde NovoBiosynthesis in Neurons

(2012) Nadine Hagen-Euteneuer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of Alzheimer Disease-associated Amyloid β42/43Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness

(2012) Edith Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal Dysfunction in a Mouse Model of Sandhoff Disease Leads to Accumulation of Ganglioside-Bound Amyloid-  Peptide

(2012) S. Keilani et al.   JOURNAL OF NEUROSCIENCE

Sphingolipids: Critical players in Alzheimer’s disease

(2012) Gerhild van Echten-Deckert et al.   PROGRESS IN LIPID RESEARCH

Plasmalogens Inhibit APP Processing by Directly Affectingγ-Secretase Activity in Alzheimer’s Disease

(2012) Tatjana L. Rothhaar et al.   TheScientificWorldJOURNAL

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo

(2012) E. R. Bastow et al.   Biology Open

Sphingolipid storage impairs autophagic clearance of Alzheimer-associated proteins

(2011) Irfan Y. Tamboli et al.   Autophagy

Lysosomal Ca2+ homeostasis: Role in pathogenesis of lysosomal storage diseases

(2011) Emyr Lloyd-Evans et al.   CELL CALCIUM

Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism

(2011) N Hagen et al.   CELL DEATH AND DIFFERENTIATION

Identification and biology of β-secretase

(2011) Patty C. Kandalepas et al.   JOURNAL OF NEUROCHEMISTRY

Sphingolipid Storage Affects Autophagic Metabolism of the Amyloid Precursor Protein and Promotes A  Generation

(2011) I. Y. Tamboli et al.   JOURNAL OF NEUROSCIENCE

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

(2011) N. Takasugi et al.   JOURNAL OF NEUROSCIENCE

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Macroautophagy Is Not Directly Involved in the Metabolism of Amyloid Precursor Protein

(2010) Barry Boland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver

(2010) Meryem Bektas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts

(2009) Ralf Frederik Claas et al.   CELLULAR SIGNALLING

Subcellular Origin of Sphingosine 1-Phosphate Is Essential for Its Toxic Effect in Lyase-deficient Neurons

(2009) Nadine Hagen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin D—Many functions of one aspartic protease

(2008) Petr Benes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY