The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders
出版年份 2019 全文链接
标题
The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders
作者
关键词
Alzheimer’s disease, Ceramide, Huntington’s disease, microRNA, Parkinson’s disease, Sphingosine-1-phosphate
出版物
MOLECULAR NEUROBIOLOGY
Volume -, Issue -, Pages -
出版商
Springer Nature
发表日期
2019-01-05
DOI
10.1007/s12035-018-1448-3
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Association of glucocerebrosidase polymorphisms and mutations with dementia in incident Parkinson's disease
- (2018) Kristin Aaser Lunde et al. Alzheimers & Dementia
- Trio approach reveals higher risk of PD in carriers of severe vs. mild GBA mutations
- (2018) David Arkadir et al. BLOOD CELLS MOLECULES AND DISEASES
- Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis
- (2018) Mariah L Hoye et al. BRAIN
- Up-regulated Pro-inflammatory MicroRNAs (miRNAs) in Alzheimer’s disease (AD) and Age-Related Macular Degeneration (AMD)
- (2018) Aileen I. Pogue et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Forkhead Transcription Factors: Formulating a FOXO Target for Cognitive Loss
- (2018) Kenneth Maiese CURRENT NEUROVASCULAR RESEARCH
- Sphingolipids in host–microbial interactions
- (2018) Stacey L Heaver et al. CURRENT OPINION IN MICROBIOLOGY
- Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F
- (2018) Nicholas U. Schwartz et al. FASEB JOURNAL
- Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson’s disease
- (2018) Vassilis E Papadopoulos et al. HUMAN MOLECULAR GENETICS
- Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood–brain barrier integrity and exerts therapeutic effect in an animal model of Huntington’s disease
- (2018) Alba Di Pardo et al. HUMAN MOLECULAR GENETICS
- Skeletal Muscle MicroRNAs as Key Players in the Pathogenesis of Amyotrophic Lateral Sclerosis
- (2018) Lorena Di Pietro et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Age-Dependent Changes to Sphingolipid Balance in the Human Hippocampus are Gender-Specific and May Sensitize to Neurodegeneration
- (2018) Timothy A. Couttas et al. JOURNAL OF ALZHEIMERS DISEASE
- Extracellular α-synuclein drives sphingosine 1-phosphate receptor subtype 1 out of lipid rafts, leading to impaired inhibitory G-protein signaling
- (2018) Shaymaa Mohamed Mohamed Badawy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NFκB signalling
- (2018) Yin-Feng Dong et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Subventricular Zone Lipidomic Architecture Loss in Huntington's Disease
- (2018) Mandana Hunter et al. JOURNAL OF NEUROCHEMISTRY
- Targeting HDAC3 Activity with RGFP966 Protects Against Retinal Ganglion Cell Nuclear Atrophy and Apoptosis After Optic Nerve Injury
- (2018) Heather M. Schmitt et al. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington's disease model
- (2018) Regina Hertfelder Reynolds et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Bacteroidetes Neurotoxins and Inflammatory Neurodegeneration
- (2018) Yuhai Zhao et al. MOLECULAR NEUROBIOLOGY
- Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer’s Disease
- (2018) Henryk Jęśko et al. MOLECULAR NEUROBIOLOGY
- Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal
- (2018) Shi Zhang et al. NEUROBIOLOGY OF AGING
- Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase
- (2018) Joanna Motyl et al. NEUROPHARMACOLOGY
- A novel p.L216I mutation in the glucocerebrosidase gene is associated with Parkinson’s disease in Han Chinese patients
- (2018) Hong Jin et al. NEUROSCIENCE LETTERS
- Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neuronal diseases. The promising target for neuroprotection in Parkinson’s disease
- (2018) Joanna Motyl et al. Pharmacological Reports
- MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice
- (2018) Peter Langfelder et al. PLoS One
- Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium
- (2018) Seung-Hyun Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The S1P Axis: New Exciting Route for Treating Huntington’s Disease
- (2018) Alba Di Pardo et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Sphingolipid Metabolism Is Dysregulated at Transcriptomic and Metabolic Levels in the Spinal Cord of an Animal Model of Amyotrophic Lateral Sclerosis
- (2018) Alexandre Henriques et al. Frontiers in Molecular Neuroscience
- Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity
- (2018) Salema B. Abul Khair et al. Frontiers in Neuroscience
- Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain
- (2018) Gaëlle Dominguez et al. Acta Neuropathologica Communications
- Fingolimod (FTY720) is not protective in the subacute MPTP mouse model of Parkinson disease and does not lead to a sustainable increase of brain BDNF
- (2018) Daniel Komnig et al. JOURNAL OF NEUROCHEMISTRY
- The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration
- (2018) Henryk Jęśko et al. MOLECULAR NEUROBIOLOGY
- Dysregulation of MicroRNAs and Target Genes Networks in Peripheral Blood of Patients With Sporadic Amyotrophic Lateral Sclerosis
- (2018) Maria Liguori et al. Frontiers in Molecular Neuroscience
- Localization of RNAi Machinery to Axonal Branch Points and Growth Cones Is Facilitated by Mitochondria and Is Disrupted in ALS
- (2018) Noga Gershoni-Emek et al. Frontiers in Molecular Neuroscience
- Wide-Ranging Analysis of MicroRNA Profiles in Sporadic Amyotrophic Lateral Sclerosis Using Next-Generation Sequencing
- (2018) Bruna De Felice et al. Frontiers in Genetics
- Bioactive Phospholipids Enhance Migration and Adhesion of Human Leukemic Cells by Inhibiting Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS) in a p38 MAPK-Dependent Manner
- (2018) Ahmed Abdelbaset-Ismail et al. Stem Cell Reviews and Reports
- Neuroprotective effects of fingolimod in mouse models of Parkinson’s disease
- (2017) Peng Zhao et al. FASEB JOURNAL
- Sphingolipid-Enriched Extracellular Vesicles and Alzheimer’s Disease: A Decade of Research
- (2017) Michael B. Dinkins et al. JOURNAL OF ALZHEIMERS DISEASE
- Involvement of Gβγ subunits of Giprotein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes
- (2017) Taketoshi Kajimoto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysosomal defects in ATP13A2 and GBA associated familial Parkinson’s disease
- (2017) Shigeto Sato et al. JOURNAL OF NEURAL TRANSMISSION
- Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease
- (2017) Yumiko V. Taguchi et al. JOURNAL OF NEUROSCIENCE
- IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function
- (2017) Joaquín Pardo et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- The release and trans-synaptic transmission of Tau via exosomes
- (2017) Yipeng Wang et al. Molecular Neurodegeneration
- Cerebrospinal fluid β-glucocerebrosidase activity is reduced in parkinson's disease patients
- (2017) Lucilla Parnetti et al. MOVEMENT DISORDERS
- Cognitive decline in Parkinson disease
- (2017) Dag Aarsland et al. Nature Reviews Neurology
- MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study
- (2017) Eric R. Reed et al. NEUROLOGY
- Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases
- (2017) Sinead O'Sullivan et al. NEUROPHARMACOLOGY
- Oligomeric α-synuclein and glucocerebrosidase activity levels in GBA-associated Parkinson’s disease
- (2017) S. Pchelina et al. NEUROSCIENCE LETTERS
- Ceramide and Its Related Neurochemical Networks as Targets for Some Brain Disorder Therapies
- (2017) Justyna Brodowicz et al. NEUROTOXICITY RESEARCH
- Disease manifestations and burden of illness in patients with acid sphingomyelinase deficiency (ASMD)
- (2017) Margaret M. McGovern et al. Orphanet Journal of Rare Diseases
- SMPD1 variants in Chinese Han patients with sporadic Parkinson's disease
- (2017) Cheng-yuan Mao et al. PARKINSONISM & RELATED DISORDERS
- Serum lipid alterations in GBA -associated Parkinson's disease
- (2017) Leonor Correia Guedes et al. PARKINSONISM & RELATED DISORDERS
- Comprehensive identification of age-related lipidome changes in rat amygdala during normal aging
- (2017) Roman Šmidák et al. PLoS One
- Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements
- (2017) Leila Pirhaji et al. Nature Communications
- Sphingolipids: membrane microdomains in brain development, function and neurological diseases
- (2017) Anne S. B. Olsen et al. Open Biology
- Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease
- (2017) Lijuan Zhang et al. MEDICAL SCIENCE MONITOR
- De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease
- (2017) Alba Di Pardo et al. Frontiers in Neuroscience
- Exosomes as Carriers of Alzheimer's Amyloid-ß
- (2017) Kohei Yuyama et al. Frontiers in Neuroscience
- Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
- (2017) Jennifer Ngolab et al. Acta Neuropathologica Communications
- Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons
- (2017) Pooja Joshi et al. Scientific Reports
- Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease
- (2017) Alba Di Pardo et al. Scientific Reports
- GM1 Ganglioside Inhibits β-Amyloid Oligomerization Induced by Sphingomyelin
- (2016) Mariana Amaro et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- LRRK2 deficiency impacts ceramide metabolism in brain
- (2016) Ruggero Ferrazza et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Glycoblotting method allows for rapid and efficient glycome profiling of human Alzheimer's disease brain, serum and cerebrospinal fluid towards potential biomarker discovery
- (2016) Solomon T. Gizaw et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Exocytosis and Spreading of Normal and Aberrant α-Synuclein
- (2016) Evangelia Emmanouilidou et al. BRAIN PATHOLOGY
- Expression of microRNA-34a in Alzheimer's disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity
- (2016) S. Sarkar et al. BRAIN RESEARCH
- Treatments and compositions targeting α-synuclein: a patent review (2010-2016)
- (2016) Henryk Jęśko et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Progress and potential of non-inhibitory small molecule chaperones for the treatment of Gaucher disease and its implications for Parkinson disease
- (2016) Olive Jung et al. Expert Review of Proteomics
- Sphingosine 1-phosphate in metabolic syndrome (Review)
- (2016) Wei Chen et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- An overview of circulating cell-free microRNAs as putative biomarkers in Alzheimer's and Parkinson's Diseases
- (2016) Meire Silva Batistela et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Ceramide channels and mitochondrial outer membrane permeability
- (2016) Marco Colombini JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice
- (2016) Guadalupe Vidal-Martínez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis
- (2016) Dan Ploug Christensen et al. Journal of Neuroinflammation
- Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse
- (2016) Michael B. Dinkins et al. JOURNAL OF NEUROSCIENCE
- Associations between plasma ceramides and cognitive and neuropsychiatric manifestations in Parkinson's disease dementia
- (2016) Yi Xing et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Neuropsychiatric characteristics of GBA-associated Parkinson disease
- (2016) Matthew Swan et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans
- (2016) Mariona Jové et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Defeating Alzheimer's disease and other dementias: a priority for European science and society
- (2016) Bengt Winblad et al. LANCET NEUROLOGY
- Revealing disease-associated pathways by network integration of untargeted metabolomics
- (2016) Leila Pirhaji et al. NATURE METHODS
- Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease
- (2016) Timothy A. Couttas et al. NEUROBIOLOGY OF AGING
- FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models
- (2016) Manru Ren et al. NEUROCHEMICAL RESEARCH
- Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis
- (2016) Rosa Luisa Potenza et al. Neurotherapeutics
- Regulation of sphingomyelin metabolism
- (2016) Kamil Bienias et al. Pharmacological Reports
- Integrated sphingosine-1 phosphate signaling in the central nervous system: From physiological equilibrium to pathological damage
- (2016) Rasoul Ghasemi et al. PHARMACOLOGICAL RESEARCH
- Circulating microRNAs in Huntington’s disease: Emerging mediators in metabolic impairment
- (2016) C. Díez-Planelles et al. PHARMACOLOGICAL RESEARCH
- GBA Variants Influence Motor and Non-Motor Features of Parkinson’s Disease
- (2016) Silvia Jesús et al. PLoS One
- Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency
- (2016) Stefka D. Spassieva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response
- (2016) Ruijuan Xu et al. Oncotarget
- Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells
- (2016) Mi-Hyeon Jeong et al. Oncotarget
- Amyloidβ Peptides in interaction with raft-mime model membranes: a neutron reflectivity insight
- (2016) Valeria Rondelli et al. Scientific Reports
- The somatotropic axis and longevity in mice
- (2015) H. M. Brown-Borg AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity
- (2015) Nobumasa Takasugi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Differential regulation of autophagy and cell viability by ceramide species
- (2015) Nichola Cruickshanks et al. CANCER BIOLOGY & THERAPY
- Growth factor treatment to overcome Alzheimer's dysfunctional signaling
- (2015) Marc-Antoine Lauzon et al. CELLULAR SIGNALLING
- P.5.c.002 Sphingosine kinase 1 mediated signalling in Parkinson's disease animal model. Neuroprotective effect of fingolimod and a D2/D3 dopamine receptor agonist
- (2015) J. Moty et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase
- (2015) Alexandre Henriques et al. HUMAN MOLECULAR GENETICS
- Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTRup-regulation and astrocyte-mediated inflammation
- (2015) Andrés Miguez et al. HUMAN MOLECULAR GENETICS
- Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils
- (2015) Max Eberle et al. IMMUNOLOGY AND CELL BIOLOGY
- Expression of Functional Sphingosine-1 Phosphate Receptor-1 Is Reduced by B Cell Receptor Signaling and Increased by Inhibition of PI3 Kinase δ but Not SYK or BTK in Chronic Lymphocytic Leukemia Cells
- (2015) Kathleen J. Till et al. JOURNAL OF IMMUNOLOGY
- miR-155 Deficiency Ameliorates Autoimmune Inflammation of Systemic Lupus Erythematosus by TargetingS1pr1inFaslpr/lprMice
- (2015) Qian Xin et al. JOURNAL OF IMMUNOLOGY
- Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs
- (2015) Amanda L. Aloia et al. MEDIATORS OF INFLAMMATION
- Systematic Genetic Analysis of the SMPD1 Gene in Chinese Patients with Parkinson’s Disease
- (2015) Sheng Deng et al. MOLECULAR NEUROBIOLOGY
- Study of plasma-derived miRNAs mimic differences in Huntington's disease brain
- (2015) Andrew G. Hoss et al. MOVEMENT DISORDERS
- Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation
- (2015) Yixuan Wang et al. NEUROBIOLOGY OF AGING
- Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosis
- (2015) J. Kuhle et al. NEUROLOGY
- Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson’s disease and in MPP+-treated MN9D cells in vitro
- (2015) M. Sivasubramanian et al. NEUROSCIENCE
- The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease
- (2015) Zhenzhen Liu et al. Oxidative Medicine and Cellular Longevity
- Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and AβAccumulation
- (2015) Maja Jazvinšćak Jembrek et al. Oxidative Medicine and Cellular Longevity
- The contribution of Niemann-Pick SMPD1 mutations to Parkinson disease in Ashkenazi Jews
- (2015) E. Dagan et al. PARKINSONISM & RELATED DISORDERS
- The emerging role of SMPD1 mutations in Parkinson's disease: Implications for future studies
- (2015) Ziv Gan-Or et al. PARKINSONISM & RELATED DISORDERS
- Maternal Plasma and Amniotic Fluid Sphingolipids Profiling in Fetal Down Syndrome
- (2015) Karol Charkiewicz et al. PLoS One
- Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis
- (2015) James C. Dodge et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease
- (2015) YaXing Gui et al. Oncotarget
- Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain
- (2015) Kai Wang et al. PLoS Genetics
- Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
- (2015) Io-Guané Rivera et al. Toxins
- Redox regulation of FoxO transcription factors
- (2015) Lars-Oliver Klotz et al. Redox Biology
- Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging
- (2014) Michelle M. Mielke et al. AGING CELL
- Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells
- (2014) Marthe-Susanna Wegner et al. BIOCHEMICAL PHARMACOLOGY
- Original article Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein
- (2014) Henryk Jesko et al. FOLIA NEUROPATHOLOGICA
- Original article The key role of sphingosine kinases in the molecular mechanism of neuronal cell survival and death in an experimental model of Parkinson’s disease
- (2014) Joanna A. Pyszko et al. FOLIA NEUROPATHOLOGICA
- Sphingolipids: Key Regulators of Apoptosis and Pivotal Players in Cancer Drug Resistance
- (2014) Paola Giussani et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein
- (2014) Ilker Karaca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- LDL Receptor and ApoE Are Involved in the Clearance of ApoM-associated Sphingosine 1-Phosphate
- (2014) Makoto Kurano et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sphingosine-1-Phosphate Mediates COX-2 Expression and PGE2/IL-6 Secretion via c-Src-Dependent AP-1 Activation
- (2014) Chih-Kai Hsu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Activation of S1P1 Receptor Regulates PI3K/Akt/FoxO3a Pathway in Response to Oxidative Stress in PC12 Cells
- (2014) Fatemeh Safarian et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans
- (2014) Roy G. Cutler et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Sphingosine Kinase 1 and Sphingosine-1-Phosphate in Oxidative Stress Evoked by 1-Methyl-4-Phenylpyridinium (MPP+) in Human Dopaminergic Neuronal Cells
- (2014) Joanna Pyszko et al. MOLECULAR NEUROBIOLOGY
- Ceramide in the Molecular Mechanisms of Neuronal Cell Death. The Role of Sphingosine-1-Phosphate
- (2014) Kinga Czubowicz et al. MOLECULAR NEUROBIOLOGY
- Sphingosine-1-Phosphate and Its Effect on Glucose Deprivation/Glucose Reload Stress: From Gene Expression to Neuronal Survival
- (2014) Kinga Czubowicz et al. MOLECULAR NEUROBIOLOGY
- Sphingolipid metabolites in inflammatory disease
- (2014) Michael Maceyka et al. NATURE
- Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease
- (2014) Michael B. Dinkins et al. NEUROBIOLOGY OF AGING
- Ceramides and sphingomyelinases in senile plaques
- (2014) Maï Panchal et al. NEUROBIOLOGY OF DISEASE
- Sphingosine Kinases/Sphingosine-1-Phosphate and Death Signalling in APP-Transfected Cells
- (2014) Magdalena Gassowska et al. NEUROCHEMICAL RESEARCH
- Fingolimod for the treatment of neurological diseases—state of play and future perspectives
- (2014) Robert Brunkhorst et al. Frontiers in Cellular Neuroscience
- Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy
- (2014) Masayuki Nagahashi et al. Biomed Research International
- Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis
- (2014) Timothy A Couttas et al. Acta Neuropathologica Communications
- Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease
- (2014) Johnatan Ceccom et al. Acta Neuropathologica Communications
- Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease
- (2013) Kohei Yuyama et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Sphingolipids and lifespan regulation
- (2013) Xinhe Huang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Autophagy paradox and ceramide
- (2013) Wenhui Jiang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Ceramide and the mitochondrial respiratory chain
- (2013) Aviram Kogot-Levin et al. BIOCHIMIE
- AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose
- (2013) Kaipeng Huang et al. CELLULAR SIGNALLING
- FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease
- (2013) Alba Di Pardo et al. HUMAN MOLECULAR GENETICS
- Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice
- (2013) Hong Cui et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Modulation of Lipid Kinase PI4KIIα Activity and Lipid Raft Association of Presenilin 1 Underlies γ-Secretase Inhibition by Ginsenoside (20S)-Rg3
- (2013) Min Suk Kang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion
- (2013) Patrick Ejlerskov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats
- (2013) Masoumeh Asle-Rousta et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson's disease
- (2013) Sarah K. Abbott et al. MOVEMENT DISORDERS
- Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
- (2013) Chia-Chen Liu et al. Nature Reviews Neurology
- Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease
- (2013) Hirosha Geekiyanage et al. NEUROBIOLOGY OF AGING
- A rare lysosomal enzyme gene SMPD1 variant (p.R591C) associates with Parkinson's disease
- (2013) Jia-Nee Foo et al. NEUROBIOLOGY OF AGING
- FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons
- (2013) Nobumasa Takasugi et al. PLoS One
- Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive Impairment: A Pilot Study
- (2013) Michelle M. Mielke et al. PLoS One
- Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1
- (2013) C Rutherford et al. Cell Death & Disease
- Lysophospholipids and their receptors in the central nervous system
- (2012) Ji Woong Choi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Ceramide function in the brain: when a slight tilt is enough
- (2012) Chiara Mencarelli et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death
- (2012) James R. Van Brocklyn et al. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
- Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)
- (2012) Guanghu Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia
- (2012) Kohei Yuyama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neutral Sphingomyelinase 2 Deficiency Increases Hyaluronan Synthesis by Up-regulation of Hyaluronan Synthase 2 through Decreased Ceramide Production and Activation of Akt
- (2012) Jingdong Qin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activity-dependent secretion of alpha-synuclein by enteric neurons
- (2012) Sébastien Paillusson et al. JOURNAL OF NEUROCHEMISTRY
- Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice
- (2012) Mei-Hong Lu et al. JOURNAL OF PHYSIOLOGY-LONDON
- Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
- (2012) Terina N Martinez et al. Molecular Neurodegeneration
- Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
- (2012) R David Sentelle et al. Nature Chemical Biology
- Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease
- (2012) M. Kosicek et al. NEUROSCIENCE LETTERS
- ASM-3 Acid Sphingomyelinase Functions as a Positive Regulator of the DAF-2/AGE-1 Signaling Pathway and Serves as a Novel Anti-Aging Target
- (2012) Yongsoon Kim et al. PLoS One
- Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin-like growth factor-1-induced myoblast differentiation
- (2012) Caterina Bernacchioni et al. Skeletal Muscle
- Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
- (2011) Joris Deelen et al. AGE
- AP-1 binding transcriptionally regulates human neutral ceramidase
- (2011) Sean M. O’Neill et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism
- (2011) N Hagen et al. CELL DEATH AND DIFFERENTIATION
- Sphingolipid signaling and neuronal function
- (2011) Shun-ichi Nakamura et al. CHEMISTRY AND PHYSICS OF LIPIDS
- Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells
- (2011) Gabriella Marfe et al. EXPERIMENTAL HEMATOLOGY
- BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate
- (2011) N. Takasugi et al. JOURNAL OF NEUROSCIENCE
- Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells
- (2011) Yuan Yuan Li et al. NEUROSCIENCE LETTERS
- Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1
- (2011) Colin Selman et al. PLoS One
- The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein
- (2011) Takafumi Hasegawa et al. PLoS One
- Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?
- (2011) Alex F. Bokov et al. PLoS One
- A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation
- (2011) Lihong Zhao et al. PLoS Genetics
- Mutations in the SPTLC2 Subunit of Serine Palmitoyltransferase Cause Hereditary Sensory and Autonomic Neuropathy Type I
- (2010) Annelies Rotthier et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease
- (2010) Xianlin Han BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Lipid mediators in the nucleus: Their potential contribution to Alzheimer's disease
- (2010) Akhlaq A. Farooqui et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage
- (2010) Andrea Huwiler et al. BRITISH JOURNAL OF PHARMACOLOGY
- Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity
- (2010) Qiong Yang et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells
- (2010) Judith Mesicek et al. CELLULAR SIGNALLING
- Plasma membrane microdomains in aging and disease
- (2010) Yoshiko Ohno-Iwashita et al. Geriatrics & Gerontology International
- Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
- (2010) Sergio E. Alvarez et al. NATURE
- Alterations of the Sphingolipid Pathway in Alzheimer’s Disease: New Biomarkers and Treatment Targets?
- (2010) Michelle M. Mielke et al. NEUROMOLECULAR MEDICINE
- The interaction of beta-amyloid protein with cellular membranes stimulates its own production
- (2009) Imke Peters et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages
- (2009) María H. Granado et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- ERK and cell death: ERK1/2 in neuronal death
- (2009) Srinivasa Subramaniam et al. FEBS Journal
- The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease
- (2009) A. N. Packer et al. JOURNAL OF NEUROSCIENCE
- Translational regulation mechanisms of AP-1 proteins
- (2009) Paul Willi Vesely et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex
- (2009) Prerna Sethi et al. NEUROSCIENCE LETTERS
- Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
- (2009) N. C. Hait et al. SCIENCE
- Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats
- (2009) Yu Hasegawa et al. STROKE
- Ceramide 1-phosphate (C1P) promotes cell migration
- (2008) María H. Granado et al. CELLULAR SIGNALLING
- Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease
- (2008) Jose Bras et al. FEBS Journal
- Phosphatidylinositol 3-Kinase/AKT Pathway Regulates the Endoplasmic Reticulum to Golgi Traffic of Ceramide in Glioma Cells
- (2008) Paola Giussani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke
- (2008) Nik Sawe et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Principles of bioactive lipid signalling: lessons from sphingolipids
- (2008) Yusuf A. Hannun et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Deregulation of sphingolipid metabolism in Alzheimer's disease
- (2008) Xingxuan He et al. NEUROBIOLOGY OF AGING
- Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
- (2008) Aileen M. Moloney et al. NEUROBIOLOGY OF AGING
- Functionally significant insulin-like growth factor I receptor mutations in centenarians
- (2008) Y. Suh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism
- (2008) Laurent Kappeler et al. PLOS BIOLOGY
- Ceramide 1-phosphate stimulates macrophage proliferation through activation of the PI3-kinase/PKB, JNK and ERK1/2 pathways
- (2007) Patricia Gangoiti et al. CELLULAR SIGNALLING
- ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain
- (2007) Veera Venkata Ratnam Bandaru et al. NEUROBIOLOGY OF AGING
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now