A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging

(2010) S. Michal Jazwinski et al.   AGING CELL

Impaired Ganglioside Metabolism in Huntington's Disease and Neuroprotective Role of GM1

(2010) V. Maglione et al.   JOURNAL OF NEUROSCIENCE

Deregulated Sphingolipid Metabolism and Membrane Organization in Neurodegenerative Disorders

(2010) Marco Piccinini et al.   MOLECULAR NEUROBIOLOGY

Alterations of the Sphingolipid Pathway in Alzheimer’s Disease: New Biomarkers and Treatment Targets?

(2010) Michelle M. Mielke et al.   NEUROMOLECULAR MEDICINE

The Role of the Ceramide Acyl Chain Length in Neurodegeneration: Involvement of Ceramide Synthases

(2010) Oshrit Ben-David et al.   NEUROMOLECULAR MEDICINE

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response

(2009) Stefka D. Spassieva et al.   BIOCHEMICAL JOURNAL

Starvation in the midst of plenty: making sense of ceramide-induced autophagy by analysing nutrient transporter expression

(2009) Aimee L. Edinger   BIOCHEMICAL SOCIETY TRANSACTIONS

Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco–Sjögren syndrome

(2009) Lihong Zhao et al.   HUMAN MOLECULAR GENETICS

Adult Ceramide Synthase 2 (CERS2)-deficient Mice Exhibit Myelin Sheath Defects, Cerebellar Degeneration, and Hepatocarcinomas

(2009) Silke Imgrund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

Protection of C. elegans from Anoxia by HYL-2 Ceramide Synthase

(2009) V. Menuz et al.   SCIENCE

Functions of sphingolipid metabolism in mammals — Lessons from genetic defects

(2008) Frédérique Sabourdy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Neuronal ceroid lipofuscinoses

(2008) Anu Jalanko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes

(2008) Guanghu Wang et al.   GLIA

Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

(2008) David Sulzer et al.   JOURNAL OF NEUROCHEMISTRY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY