Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F

Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy

(2017) Derek Atkinson et al.   NEUROLOGY

Autophagy as an Emerging Common Pathomechanism in Inherited Peripheral Neuropathies

(2017) Mansour Haidar et al.   Frontiers in Molecular Neuroscience

Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death

(2016) K. Sundaram et al.   BIOCHEMICAL JOURNAL

Phosphorylated heat shock protein 27 promotes lipid clearance in hepatic cells through interacting with STAT3 and activating autophagy

(2016) Lei Shen et al.   CELLULAR SIGNALLING

HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation

(2016) Ji-Yon Kim et al.   Stem Cells International

Small heat shock proteins: Role in cellular functions and pathology

(2015) Raman Bakthisaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase

(2015) Alexandre Henriques et al.   HUMAN MOLECULAR GENETICS

Sphingolipids and mitochondrial apoptosis

(2015) Gauri A. Patwardhan et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death

(2015) María José Hernández-Corbacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner

(2015) Tejas S. Tirodkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Release of mitochondrial Opa1 following oxidative stress in HT22 cells

(2015) Thomas H. Sanderson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

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(2015) Heather L. Smith et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors

(2015) Michael S Fleming et al.   eLife

Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury

(2015) Tatsuki Matsumoto et al.   PLoS One

Charcot-Marie-Tooth disease and pathways to molecular based therapies

(2014) T. Harel et al.   CLINICAL GENETICS

Genetics of Charcot-Marie-Tooth (CMT) Disease within the Frame of the Human Genome Project Success

(2014) Vincent Timmerman et al.   Genes

Animal models and therapeutic prospects for Charcot-Marie-Tooth disease

(2013) Delphine Bouhy et al.   ANNALS OF NEUROLOGY

Overexpression of Hsp27 ameliorates symptoms of Alzheimer's disease in APP/PS1 mice

(2013) Melinda Erzsébet Tóth et al.   CELL STRESS & CHAPERONES

Treatment outcomes for Mycobacterium avium complex: a systematic review and meta-analysis

(2013) H.-B. Xu et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Human-Derived Physiological Heat Shock Protein 27 Complex Protects Brain after Focal Cerebral Ischemia in Mice

(2013) Shinichiro Teramoto et al.   PLoS One

Heat Shock Protein B1-Deficient Mice Display Impaired Wound Healing

(2013) Jonathan Crowe et al.   PLoS One

Morphological abnormalities in mitochondria of the skin of patients with sporadic amyotrophic lateral sclerosis

(2012) Gabriel E. Rodríguez et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Ceramide synthases at the centre of sphingolipid metabolism and biology

(2012) Thomas D. Mullen et al.   BIOCHEMICAL JOURNAL

Modulation of Ceramide Synthase Activity via Dimerization

(2012) Elad L. Laviad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease

(2012) Weilin Xie et al.   JOURNAL OF NEUROCHEMISTRY

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice

(2012) Amit K. Srivastava et al.   NEUROBIOLOGY OF DISEASE

Serum ceramides increase the risk of Alzheimer disease: The Women's Health and Aging Study II

(2012) M. M. Mielke et al.   NEUROLOGY

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways

(2011) S. M. Lee et al.   JOURNAL OF CELL SCIENCE

Small Heat-Shock Protein HSPB1 Mutants Stabilize Microtubules in Charcot-Marie-Tooth Neuropathy

(2011) L. Almeida-Souza et al.   JOURNAL OF NEUROSCIENCE

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

(2011) Constantin d'Ydewalle et al.   NATURE MEDICINE

Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

(2011) Hyunmi Lee et al.   PLoS One

A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

(2011) Lihong Zhao et al.   PLoS Genetics

The Charcot-Marie-Tooth syndrome: clinical aspects from a population study in South Wales, UK

(2010) John C. MacMillan et al.   CLINICAL GENETICS

Hereditary Sensory Neuropathy Type 1 Is Caused by the Accumulation of Two Neurotoxic Sphingolipids

(2010) Anke Penno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel HSPB1 mutation in an Italian patient with CMT2/dHMN phenotype

(2010) M. Luigetti et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Deregulated Sphingolipid Metabolism and Membrane Organization in Neurodegenerative Disorders

(2010) Marco Piccinini et al.   MOLECULAR NEUROBIOLOGY

Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing

(2009) Priya Sridevi et al.   EXPERIMENTAL CELL RESEARCH

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20

(2009) C. Bagnéris et al.   JOURNAL OF MOLECULAR BIOLOGY

Long-chain Ceramide Is a Potent Inhibitor of the Mitochondrial Permeability Transition Pore

(2008) Sergei A. Novgorodov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HT22 hippocampal neuronal cell line possesses functional cholinergic properties

(2008) Jun Liu et al.   LIFE SCIENCES

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression

(2007) Paul S. Sharp et al.   NEUROBIOLOGY OF DISEASE