FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice

From microRNA target validation to therapy: lessons learned from studies on BDNF

(2015) Kärt Varendi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTRup-regulation and astrocyte-mediated inflammation

(2015) Andrés Miguez et al.   HUMAN MOLECULAR GENETICS

FTY720 attenuates excitotoxicity and neuroinflammation

(2015) Raffaela Cipriani et al.   Journal of Neuroinflammation

Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy

(2015) Keiko Nakamura et al.   Acta Neuropathologica Communications

Brain-derived neurotrophic factor accelerates gut motility in slow-transit constipation

(2014) F. Chen et al.   Acta Physiologica

Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment

(2014) Kazuya Fukumoto et al.   BEHAVIOURAL BRAIN RESEARCH

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

(2014) Nitai C Hait et al.   NATURE NEUROSCIENCE

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

Multiple system atrophy as emerging template for accelerated drug discovery in α-synucleinopathies

(2014) Florian Krismer et al.   PARKINSONISM & RELATED DISORDERS

Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells

(2014) Javier Vargas-Medrano et al.   ACS Medicinal Chemistry Letters

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease

(2013) Alba Di Pardo et al.   HUMAN MOLECULAR GENETICS

Non-motor parkinsonian pathology in aging A53T α-Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function

(2013) Kaitlin F. Farrell et al.   JOURNAL OF NEUROCHEMISTRY

Submandibular Gland Biopsy for the Diagnosis of Parkinson Disease

(2013) Thomas G. Beach et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

Fingolimod Phosphate Attenuates Oligomeric Amyloid β–Induced Neurotoxicity via Increased Brain-Derived Neurotrophic Factor Expression in Neurons

(2013) Yukiko Doi et al.   PLoS One

The prion hypothesis in Parkinson's disease: Braak to the future

(2013) Naomi P Visanji et al.   Acta Neuropathologica Communications

Bleach gel: A simple agarose gel for analyzing RNA quality

(2012) Patrick S. Aranda et al.   ELECTROPHORESIS

Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?

(2012) Carla M. Lema Tomé et al.   MOLECULAR NEUROBIOLOGY

Is alpha-synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases

(2012) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo

(2012) J. Wu et al.   NEUROSCIENCE

Fingolimod protects cultured cortical neurons against excitotoxic death

(2012) Luisa Di Menna et al.   PHARMACOLOGICAL RESEARCH

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons

(2011) Lishi Li et al.   CELL

Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice

(2011) Maxime Cazorla et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential Roles of Enteric Neuronal Serotonin in Gastrointestinal Motility and the Development/Survival of Enteric Dopaminergic Neurons

(2011) Z. Li et al.   JOURNAL OF NEUROSCIENCE

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease

(2011) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNAs in neurodegenerative diseases and their therapeutic potential

(2011) Eunsung Junn et al.   PHARMACOLOGY & THERAPEUTICS

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes

(2010) Yien-Ming Kuo et al.   HUMAN MOLECULAR GENETICS

Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2Ain Vitroandin Vivo

(2010) Haiyan Lou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Localization of Sphingosine-1-phosphate Receptor 1 Expression in the Human Central Nervous System

(2010) Hirotake Nishimura et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Running wheel activity restores MPTP-induced functional deficits

(2010) Anders Fredriksson et al.   JOURNAL OF NEURAL TRANSMISSION

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Expansion of the Parkinson disease-associated SNCA- Rep1 allele upregulates human α-synuclein in transgenic mouse brain

(2009) Kenneth D. Cronin et al.   HUMAN MOLECULAR GENETICS

Nonmotor Symptoms of Parkinson's Disease Revealed in an Animal Model with Reduced Monoamine Storage Capacity

(2009) T. N. Taylor et al.   JOURNAL OF NEUROSCIENCE

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

Medical records documentation of constipation preceding Parkinson disease: A case-control study

(2009) R. Savica et al.   NEUROLOGY

Non-motor extranigral signs and symptoms in Parkinson's disease

(2009) Erik Ch. Wolters   PARKINSONISM & RELATED DISORDERS

Specificity and Regulation of Casein Kinase-Mediated Phosphorylation of α-Synuclein

(2008) Elisa A. Waxman et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice

(2008) Tshianda N.M. Alerte et al.   NEUROSCIENCE LETTERS