Sphingolipids: Key Regulators of Apoptosis and Pivotal Players in Cancer Drug Resistance

Galactosylceramide Affects Tumorigenic and Metastatic Properties of Breast Cancer Cells as an Anti-Apoptotic Molecule

(2014) Tomasz B. Owczarek et al.   PLoS One

Novel Agents Targeting Bioactive Sphingolipids for the Treatment of Cancer

(2013) A. Adan-Gokbulut et al.   CURRENT MEDICINAL CHEMISTRY

Glioma Cell Death Induced by Irradiation or Alkylating Agent Chemotherapy Is Independent of the Intrinsic Ceramide Pathway

(2013) Dorothee Gramatzki et al.   PLoS One

Extracellular Sphingosine-1-Phosphate: A Novel Actor in Human Glioblastoma Stem Cell Survival

(2013) Elena Riccitelli et al.   PLoS One

Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding

(2013) Arshawn Sami et al.   TUMOR BIOLOGY

Constitutive localization of DR4 in lipid rafts is mandatory for TRAIL-induced apoptosis in B-cell hematologic malignancies

(2013) M Marconi et al.   Cell Death & Disease

Ceramide-Based Therapeutics for the Treatment of Cancer

(2012) Brian M. Barth et al.   Anti-Cancer Agents in Medicinal Chemistry

Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor

(2012) Seung-Yeol Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival

(2012) Julien Véret et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

VHL-Regulated MiR-204 Suppresses Tumor Growth through Inhibition of LC3B-Mediated Autophagy in Renal Clear Cell Carcinoma

(2012) Olga Mikhaylova et al.   CANCER CELL

Glucosylceramide Synthase Protects Glioblastoma Cells Against Autophagic and Apoptotic Death Induced by Temozolomide and Paclitaxel

(2012) P. Giussani et al.   CANCER INVESTIGATION

Loss of the Ceramide Transfer Protein Augments EGF Receptor Signaling in Breast Cancer

(2012) J. Heering et al.   CANCER RESEARCH

Detection of N-glycolyated gangliosides in non-small-cell lung cancer using GMR8 monoclonal antibody

(2012) Nobuyoshi Hayashi et al.   CANCER SCIENCE

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

Inhibition of sphingosine kinase 1 suppresses proliferation of glioma cells under hypoxia by attenuating activity of extracellular signal-regulated kinase

(2012) H. Zhang et al.   CELL PROLIFERATION

The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells

(2012) Sonia-Caroline Sorli et al.   FASEB JOURNAL

Absence of death receptor translocation into lipid rafts in acquired TRAIL-resistant NSCLC cells

(2012) WEN OUYANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Plasma Membrane Sialidase NEU3 Regulates the Malignancy of Renal Carcinoma Cells by Controlling β1 Integrin Internalization and Recycling

(2012) Cristina Tringali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NEU3 Sialidase Is Activated under Hypoxia and Protects Skeletal Muscle Cells from Apoptosis through the Activation of the Epidermal Growth Factor Receptor Signaling Pathway and the Hypoxia-inducible Factor (HIF)-1α

(2012) Raffaella Scaringi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

(2012) Megan M. Young et al.   JOURNAL OF LIPID RESEARCH

Dysregulation of sphingolipid metabolism in cancer

(2011) Lindsay K. Ryland et al.   CANCER BIOLOGY & THERAPY

Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides

(2011) Maiko Miyata et al.   CANCER SCIENCE

Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells

(2011) Sung-Chul Lim et al.   CARCINOGENESIS

Plasma membrane-associated sialidase (NEU3) regulates progression of prostate cancer to androgen-independent growth through modulation of androgen receptor signaling

(2011) S Kawamura et al.   CELL DEATH AND DIFFERENTIATION

Immunology in the clinic review series; focus on cancer: glycolipids as targets for tumour immunotherapy

(2011) L. G. Durrant et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A Phase I Clinical Trial of Safingol in Combination with Cisplatin in Advanced Solid Tumors

(2011) M. A. Dickson et al.   CLINICAL CANCER RESEARCH

Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage

(2011) Sandrine Lépine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New findings on nuclear gangliosides: overview on metabolism and function

(2011) Robert Ledeen et al.   JOURNAL OF NEUROCHEMISTRY

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

(2011) Alvin J. X. Lee et al.   JOURNAL OF PATHOLOGY

Death receptor 4 is preferentially recruited to lipid rafts in chronic lymphocytic leukemia cells contributing to tumor necrosis related apoptosis inducing ligand-induced synergistic apoptotic responses

(2011) Wenyan Xiao et al.   LEUKEMIA & LYMPHOMA

Targeting the GD3 acetylation pathway selectively induces apoptosis in glioblastoma

(2011) Suzanne M. Birks et al.   NEURO-ONCOLOGY

Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy

(2011) G. Barcelo-Coblijn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

The epithelial-mesenchymal transition (EMT) phenomenon

(2010) P. Savagner   ANNALS OF ONCOLOGY

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

(2010) Yohannes Mebratu et al.   CELL CYCLE

Ceramide kinase: The first decade

(2010) Frédéric Bornancin   CELLULAR SIGNALLING

A Novel Sphingosine Kinase Inhibitor Induces Autophagy in Tumor Cells

(2010) V. Beljanski et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling

(2010) Yong-Yu Liu et al.   Molecular Cancer

Expression of verotoxin-1 receptor Gb3 in breast cancer tissue and verotoxin-1 signal transduction to apoptosis

(2009) David Johansson et al.   BMC CANCER

De-N-acetyl GM3 Promotes Melanoma Cell Migration and Invasion through Urokinase Plasminogen Activator Receptor Signaling-Dependent MMP-2 Activation

(2009) J.-W. Liu et al.   CANCER RESEARCH

Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

(2009) D. Kapitonov et al.   CANCER RESEARCH

Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death

(2009) E Lafont et al.   CELL DEATH AND DIFFERENTIATION

Restoring Endocrine Response in Breast Cancer Cells by Inhibition of the Sphingosine Kinase-1 Signaling Pathway

(2009) Olga Sukocheva et al.   ENDOCRINOLOGY

Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility

(2009) Sen-itiroh Hakomori   FEBS LETTERS

Down regulation of membrane-bound Neu3 constitutes a new potential marker for childhood acute lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells

(2009) Chandan Mandal et al.   INTERNATIONAL JOURNAL OF CANCER

Death receptor 5-recruited raft components contributes to the sensitivity of Jurkat leukemia cell lines to TRAIL-induced cell death

(2009) Yifan Min et al.   IUBMB LIFE

Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer

(2009) Eugen Ruckhäberle et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Shiga Toxin Receptor Gb3Cer/CD77: Tumor-Association and Promising Therapeutic Target in Pancreas and Colon Cancer

(2009) Ute Distler et al.   PLoS One

Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines

(2009) F. Guan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Regulation and functions of sphingosine kinases in the brain

(2008) L BRYAN   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate

(2008) C MAO   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3

(2008) C Tringali et al.   CELL DEATH AND DIFFERENTIATION

Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease

(2008) S PYNE et al.   CELLULAR SIGNALLING

Targeting SphK1 as a New Strategy against Cancer

(2008) Dai Shida et al.   CURRENT DRUG TARGETS

NEU3 Sialidase Strictly Modulates GM3 Levels in Skeletal Myoblasts C2C12 Thus Favoring Their Differentiation and Protecting Them from Apoptosis

(2008) Luigi Anastasia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 3-Kinase/AKT Pathway Regulates the Endoplasmic Reticulum to Golgi Traffic of Ceramide in Glioma Cells

(2008) Paola Giussani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia

(2008) Kankana Mukherjee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Disialoganglioside GD3 synthase expression recruits membrane transglutaminase 2 during erythroid differentiation of the human chronic myelogenous leukemia K562 cells

(2008) Sung-Koo Kang et al.   PROTEOMICS

Roles of plasma membrane-associated sialidase NEU3 in human cancers

(2007) Taeko Miyagi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS