Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

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Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages

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FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats

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Fingolimod Phosphate Attenuates Oligomeric Amyloid β–Induced Neurotoxicity via Increased Brain-Derived Neurotrophic Factor Expression in Neurons

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FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons

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Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate

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Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release

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Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

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(2011) Lesley J. Scott   CNS DRUGS

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Sphingosine Kinase 1 and Sphingosine 1-Phosphate Receptor 3 Are Functionally Upregulated on Astrocytes under Pro-Inflammatory Conditions

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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

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Deregulation of sphingolipid metabolism in Alzheimer's disease

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