Sphingolipids: membrane microdomains in brain development, function and neurological diseases

Increased Ceramide in Brains with Alzheimer's and Other Neurodegenerative Diseases

(2018) Valery Filippov et al.   JOURNAL OF ALZHEIMERS DISEASE

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tandem Mass Spectrometry Multiplex Analysis of Glucosylceramide and Galactosylceramide Isoforms in Brain Tissues at Different Stages of Parkinson Disease

(2016) Michel Boutin et al.   ANALYTICAL CHEMISTRY

GM1 Ganglioside Inhibits β-Amyloid Oligomerization Induced by Sphingomyelin

(2016) Mariana Amaro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acid ceramidase and the treatment of ceramide diseases: The expanding role of enzyme replacement therapy

(2016) Edward H. Schuchman   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of sphingolipids in neuronal plasticity of the brain

(2016) Sandro Sonnino et al.   JOURNAL OF NEUROCHEMISTRY

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

Exosomes in Alzheimer's disease

(2016) Tarja Malm et al.   NEUROCHEMISTRY INTERNATIONAL

Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency

(2016) Stefka D. Spassieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid membrane domains in the brain

(2015) Massimo Aureli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Organization and functions of glycolipid-enriched microdomains in phagocytes

(2015) Roudy C. Ekyalongo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

GluN2B-containing NMDA receptors are upregulated in plasma membranes by the sphingosine-1-phosphate analog FTY720P

(2015) Suzanne Attiori Essis et al.   BRAIN RESEARCH

Spinal muscular atrophy associated with progressive myoclonic epilepsy: A rare condition caused by mutations inASAH1

(2015) Guido Rubboli et al.   EPILEPSIA

Role of sphingomyelinases in neurological disorders

(2015) Wei-Yi Ong et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression

(2015) Erich Gulbins et al.   JOURNAL OF NEUROCHEMISTRY

No evidence for substrate accumulation in Parkinson brains withGBAmutations

(2015) Matthew E. Gegg et al.   MOVEMENT DISORDERS

Evidence for the role of lipid rafts and sphingomyelin in Ca2+-gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals

(2015) Éva Sághy et al.   PHARMACOLOGICAL RESEARCH

Gangliosides: glycosphingolipids essential for normal neural development and function

(2015) Cara-Lynne Schengrund   TRENDS IN BIOCHEMICAL SCIENCES

The Role of Gangliosides in Neurodevelopment

(2015) Kate Palmano et al.   Nutrients

Identification of novel sphingolipid-binding motifs in mammalian membrane proteins

(2014) Patrik Björkholm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease

(2014) Karen E. Murphy et al.   BRAIN

Human genetic disorders of sphingolipid biosynthesis

(2014) Leonardo Astudillo et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Ganglioside GD3 Is Required for Neurogenesis and Long-Term Maintenance of Neural Stem Cells in the Postnatal Mouse Brain

(2014) Jing Wang et al.   JOURNAL OF NEUROSCIENCE

Lipid dynamics at dendritic spines

(2014) Carlos Gerardo Dotti et al.   Frontiers in Neuroanatomy

Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy

(2014) Mai-Britt Mosbech et al.   Annals of Clinical and Translational Neurology

Evidence for clinical, genetic and biochemical variability in spinal muscular atrophy with progressive myoclonic epilepsy

(2013) D.A. Dyment et al.   CLINICAL GENETICS

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

(2013) Erich Gulbins et al.   NATURE MEDICINE

The ganglioside GQ1b regulates BDNF expression via the NMDA receptor signaling pathway

(2013) Min Kyoo Shin et al.   NEUROPHARMACOLOGY

Lipid raft disarrangement as a result of neuropathological progresses: A novel strategy for early diagnosis?

(2013) R. Marin et al.   NEUROSCIENCE

Interaction of ganglioside GD3 with an EGF receptor sustains the self-renewal ability of mouse neural stem cells in vitro

(2013) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinal Muscular Atrophy Associated with Progressive Myoclonic Epilepsy Is Caused by Mutations in ASAH1

(2012) Jie Zhou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains

(2012) Matthew E. Gegg et al.   ANNALS OF NEUROLOGY

Ceramide synthases at the centre of sphingolipid metabolism and biology

(2012) Thomas D. Mullen et al.   BIOCHEMICAL JOURNAL

Refractory epilepsy and mitochondrial dysfunction due to GM3 synthase deficiency

(2012) Konstantina Fragaki et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Glucocerebrosidasemutations in a Serbian Parkinson's disease population

(2012) K. R. Kumar et al.   EUROPEAN JOURNAL OF NEUROLOGY

Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes

(2012) Joo-Won Park et al.   HEPATOLOGY

Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes

(2012) Christina Ginkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes

(2012) Liana C. Silva et al.   JOURNAL OF LIPID RESEARCH

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

(2012) Megan M. Young et al.   JOURNAL OF LIPID RESEARCH

Essential Roles of Gangliosides in the Formation and Maintenance of Membrane Microdomains in Brain Tissues

(2012) Yuhsuke Ohmi et al.   NEUROCHEMICAL RESEARCH

The Roles of Neutral Sphingomyelinases in Neurological Pathologies

(2012) Charles R. Horres et al.   NEUROCHEMICAL RESEARCH

Lipid Rafts and Alzheimer’s Disease: Protein-Lipid Interactions and Perturbation of Signaling

(2012) David A. Hicks et al.   Frontiers in Physiology

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

(2011) Alfred H. Merrill   CHEMICAL REVIEWS

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

(2011) Robin B. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Encephalopathy Caused by Ablation of Very Long Acyl Chain Ceramide Synthesis May Be Largely Due to Reduced Galactosylceramide Levels

(2011) Oshrit Ben-David et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The α7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membrane

(2011) José O. Colón-Sáez et al.   JOURNAL OF PHYSIOLOGY-LONDON

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(2011) Noemi Fabelo et al.   MOLECULAR MEDICINE

Cholesterol: A Novel Regulatory Role in Myelin Formation

(2011) Gesine Saher et al.   NEUROSCIENTIST

Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

(2011) Xianlin Han et al.   PLoS One

Cholesterol metabolism in neurons and astrocytes

(2011) Frank W. Pfrieger et al.   PROGRESS IN LIPID RESEARCH

A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

(2011) Lihong Zhao et al.   PLoS Genetics

Metabolic Depletion of Sphingolipids Impairs Ligand Binding and Signaling of Human Serotonin1AReceptors

(2010) Yamuna Devi Paila et al.   BIOCHEMISTRY

Synapse Pathology in Psychiatric and Neurologic Disease

(2010) Myrrhe van Spronsen et al.   Current Neurology and Neuroscience Reports

Mammalian ceramide synthases

(2010) Michal Levy et al.   IUBMB LIFE

A Critical Role for Ceramide Synthase 2 in Liver Homeostasis

(2010) Yael Pewzner-Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice

(2010) Nino Tabatadze et al.   JOURNAL OF NEUROSCIENCE RESEARCH

SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function

(2010) Caroline Dart   JOURNAL OF PHYSIOLOGY-LONDON

Deregulated Sphingolipid Metabolism and Membrane Organization in Neurodegenerative Disorders

(2010) Marco Piccinini et al.   MOLECULAR NEUROBIOLOGY

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes

(2009) Motohiro Tani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Roles and regulation of secretory and lysosomal acid sphingomyelinase

(2009) Russell W. Jenkins et al.   CELLULAR SIGNALLING

Effect of lipid raft disruption on TRPV1 receptor activation of trigeminal sensory neurons and transfected cell line

(2009) Éva Szőke et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Participation of galactosylceramide and sulfatide in glycosynapses between oligodendrocyte or myelin membranes

(2009) Joan M. Boggs et al.   FEBS LETTERS

Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction

(2009) Elena Posse de Chaves et al.   FEBS LETTERS

Very long chain sphingolipids: Tissue expression, function and synthesis

(2009) Roger Sandhoff   FEBS LETTERS

Adult Ceramide Synthase 2 (CERS2)-deficient Mice Exhibit Myelin Sheath Defects, Cerebellar Degeneration, and Hepatocarcinomas

(2009) Silke Imgrund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

(2009) Ana M. Vacaru et al.   JOURNAL OF CELL BIOLOGY

Tumor necrosis factor-α-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors

(2009) David Wheeler et al.   JOURNAL OF NEUROCHEMISTRY

Myelin-associated glycoprotein and its axonal receptors

(2009) Ronald L. Schnaar et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Proteome Scale Characterization of HumanS-Acylated Proteins in Lipid Raft-enriched and Non-raft Membranes

(2009) Wei Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

Interactions between lipids and voltage sensor paddles detected with tarantula toxins

(2009) Mirela Milescu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid β-protein fibrillogenesis

(2008) Naoki Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ganglioside depletion and EGF responses of human GM3 synthase-deficient fibroblasts

(2008) Yihui Liu et al.   GLYCOBIOLOGY

Thematic Review Series: Sphingolipids.Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease—a review,

(2008) Toshio Ariga et al.   JOURNAL OF LIPID RESEARCH

Thematic Review Series: Sphingolipids.Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols

(2008) Sarah T. Pruett et al.   JOURNAL OF LIPID RESEARCH

Removal of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channels

(2008) Yanping Xu et al.   NATURE

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

(2008) Christian Eggeling et al.   NATURE

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING