Differential regulation of autophagy and cell viability by ceramide species

PP2A Inhibition Is a Common Event in Colorectal Cancer and Its Restoration Using FTY720 Shows Promising Therapeutic Potential

(2014) I. Cristobal et al.   MOLECULAR CANCER THERAPEUTICS

Erratum: The pleiotropic roles of sphingolipid signaling in autophagy

(2014) Y Li et al.   Cell Death & Disease

Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells

(2013) Hossein A Hamed et al.   CANCER BIOLOGY & THERAPY

Regulation of autophagy by stress-responsive transcription factors

(2013) Federico Pietrocola et al.   SEMINARS IN CANCER BIOLOGY

Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling

(2012) M. Danielle Bareford et al.   CANCER BIOLOGY & THERAPY

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

(2012) M. Nagahashi et al.   CANCER RESEARCH

Autophagy in tumor suppression and cancer therapy

(2012) Che-Pei Kung et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

Autophagy induced by FTY720 promotes apoptosis in U266 cells

(2012) Aijun Liao et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell–dependent murine model of allergic asthma

(2012) Megan M. Price et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Antifolate Inhibitors of Thymidylate Synthase as Anticancer Drugs

(2012) A. Jarmula   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells

(2011) Craig T. Wallington-Beddoe et al.   Autophagy

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Sorafenib Enhances Pemetrexed Cytotoxicity through an Autophagy-Dependent Mechanism in Cancer Cells

(2011) M. D. Bareford et al.   CANCER RESEARCH

Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide

(2011) Qing Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

Regulation of autophagy in hematological malignancies: role of reactive oxygen species

(2011) Ganchimeg Ishdorj et al.   LEUKEMIA & LYMPHOMA

FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy

(2010) Ning Zhang et al.   Autophagy

PERK-Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24-Induced Killing of Primary Human Glioblastoma Multiforme Cells

(2010) A. Yacoub et al.   CANCER RESEARCH

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen Species-Dependent Signaling Pathway

(2010) M. A. Park et al.   CANCER RESEARCH

Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas

(2010) S. B. Rothbart et al.   CANCER RESEARCH

17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species

(2010) T. Walker et al.   MOLECULAR CANCER THERAPEUTICS

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutics by Cytotoxic Metabolite Accumulation: Pemetrexed Causes ZMP Accumulation, AMPK Activation, and Mammalian Target of Rapamycin Inhibition

(2009) Alexandra C. Racanelli et al.   CANCER RESEARCH

Ceramide Synthesis Is Modulated by the Sphingosine Analog FTY720 via a Mixture of Uncompetitive and Noncompetitive Inhibition in an Acyl-CoA Chain Length-de pend ent Manner

(2009) Sujoy Lahiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FTY720 Induces Apoptosis in Hepatocellular Carcinoma Cells through Activation of Protein Kinase C   Signaling

(2008) J.-H. Hung et al.   CANCER RESEARCH

Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

(2008) N. T. Ihle et al.   CANCER RESEARCH