Treatments and compositions targeting α-synuclein: a patent review (2010-2016)

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

(2016) Emma Deas et al.   ANTIOXIDANTS & REDOX SIGNALING

The utility of α-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature

(2016) Anja Hviid Simonsen et al.   Biomarkers in Medicine

The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease

(2016) Matthew J. Benskey et al.   JOURNAL OF NEUROCHEMISTRY

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease

(2016) Nour K. Majbour et al.   Molecular Neurodegeneration

Biomarkers in Parkinson's disease: Advances and strategies

(2016) Marion Delenclos et al.   PARKINSONISM & RELATED DISORDERS

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

(2016) Marija Iljina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes

(2015) Corinna Bliederhaeuser et al.   ACTA NEUROPATHOLOGICA

Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, andin Vivo

(2015) Martial Kamdem Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization

(2015) Filsy Samuel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease

(2015) Yan Xu et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells

(2015) Katharina Pukaß et al.   JOURNAL OF NEUROCHEMISTRY

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration

(2015) Anne-Sophie Van Rompuy et al.   Molecular Neurodegeneration

Increased oligomerization and phosphorylation of α-synuclein are associated with decreased activity of glucocerebrosidase and protein phosphatase 2A in aging monkey brains

(2015) Guangwei Liu et al.   NEUROBIOLOGY OF AGING

Detection of α-synuclein oligomers in red blood cells as a potential biomarker of Parkinson’s disease

(2015) Xuemei Wang et al.   NEUROSCIENCE LETTERS

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

(2015) Ulf Dettmer et al.   Nature Communications

Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein

(2015) Eduard Bentea et al.   Frontiers in Behavioral Neuroscience

Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease

(2015) Scarlet Gallegos et al.   Frontiers in Neuroscience

Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein

(2015) Cristine Betzer et al.   PLoS One

Original article Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein

(2014) Henryk Jesko et al.   FOLIA NEUROPATHOLOGICA

Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models

(2014) D. Games et al.   JOURNAL OF NEUROSCIENCE

Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes

(2014) Laura A. Volpicelli-Daley et al.   MOLECULAR BIOLOGY OF THE CELL

Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

(2014) Magdalena Gąssowska et al.   PLoS One

Calcineurin determines toxic versus beneficial responses to  -synuclein

(2014) G. Caraveo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein

(2014) Eun-Jin Bae et al.   Nature Communications

Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson’s disease with dementia and dementia with Lewy bodies compared to Alzheimer’s disease

(2014) Oskar Hansson et al.   Alzheimers Research & Therapy

Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers

(2014) Jan O. Aasly et al.   Frontiers in Aging Neuroscience

The regulation of catalase activity by PPARγis affected byα-synuclein

(2014) Eugenia Yakunin et al.   Annals of Clinical and Translational Neurology

Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro

(2013) Grzegorz A. Czapski et al.   FEBS LETTERS

Oxidative Stress Promotes Uptake, Accumulation, and Oligomerization of Extracellular α-Synuclein in Oligodendrocytes

(2013) Katharina Pukaß et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Modulation of human α-synuclein aggregation by a combined effect of calcium and dopamine

(2013) Manish Kumar Jain et al.   NEUROBIOLOGY OF DISEASE

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

(2013) C. Y. Chung et al.   SCIENCE

Sustained expression of PGC-1  in the rat nigrostriatal system selectively impairs dopaminergic function

(2012) C. Ciron et al.   HUMAN MOLECULAR GENETICS

Alpha-Synuclein Posttranslational Modification and Alternative Splicing as a Trigger for Neurodegeneration

(2012) Katrin Beyer et al.   MOLECULAR NEUROBIOLOGY

Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson’s disease

(2011) Jinxia Zhou et al.   ACTA NEUROPATHOLOGICA

Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β

(2011) Fumitaka Kawakami et al.   FEBS Journal

Oxidants induce alternative splicing of α-synuclein: Implications for Parkinson's disease

(2009) Shasi V. Kalivendi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Clearance and deposition of extracellular α-synuclein aggregates in microglia

(2008) He-Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions

(2008) Melinda A. McFarland et al.   MOLECULAR & CELLULAR PROTEOMICS

α-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells

(2008) Anna Kazmierczak et al.   NEUROCHEMISTRY INTERNATIONAL