Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson’s disease
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson’s disease
Authors
Keywords
-
Journal
HUMAN MOLECULAR GENETICS
Volume -, Issue -, Pages -
Publisher
Oxford University Press (OUP)
Online
2018-03-12
DOI
10.1093/hmg/ddy075
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Oligomeric α-synuclein and glucocerebrosidase activity levels in GBA-associated Parkinson’s disease
- (2017) S. Pchelina et al. NEUROSCIENCE LETTERS
- Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid
- (2017) Mohammad Shahnawaz et al. JAMA Neurology
- Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats
- (2016) Maria Xilouri et al. Autophagy
- Exocytosis and Spreading of Normal and Aberrant α-Synuclein
- (2016) Evangelia Emmanouilidou et al. BRAIN PATHOLOGY
- The relationship between glucocerebrosidase mutations and Parkinson disease
- (2016) Anna Migdalska-Richards et al. JOURNAL OF NEUROCHEMISTRY
- α-Synuclein dimerization in erythrocytes of Gaucher disease patients: correlation with lipid abnormalities and oxidative stress
- (2016) Marina Moraitou et al. NEUROSCIENCE LETTERS
- ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
- (2016) Hugo J.R. Fernandes et al. Stem Cell Reports
- Gaucher-related synucleinopathies: The examination of sporadic neurodegeneration from a rare (disease) angle
- (2015) S. Pablo Sardi et al. PROGRESS IN NEUROBIOLOGY
- Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation
- (2014) Ianai Fishbein et al. BRAIN
- Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice
- (2014) You-hai Xu et al. HUMAN MOLECULAR GENETICS
- Acceleration of α-Synuclein Aggregation by Exosomes
- (2014) Marie Grey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis
- (2014) David C. Schöndorf et al. Nature Communications
- Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein
- (2014) Eun-Jin Bae et al. Nature Communications
- iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease
- (2014) Chris M. Woodard et al. Cell Reports
- Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease
- (2013) Laura D. Osellame et al. Cell Metabolism
- Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion
- (2013) Patrick Ejlerskov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction
- (2013) Edward I. Ginns et al. MOLECULAR GENETICS AND METABOLISM
- Loss of β-Glucocerebrosidase Activity Does Not Affect Alpha-Synuclein Levels or Lysosomal Function in Neuronal Cells
- (2013) Georgia Dermentzaki et al. PLoS One
- Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies
- (2013) S. Pablo Sardi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space
- (2012) Rocio Perez-Gonzalez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The link between the GBA gene and parkinsonism
- (2012) Ellen Sidransky et al. LANCET NEUROLOGY
- GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology
- (2012) D. Tsuang et al. NEUROLOGY
- Increased dimerization of alpha-synuclein in erythrocytes in Gaucher disease and aging
- (2012) Assimina Argyriou et al. NEUROSCIENCE LETTERS
- Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing
- (2011) Valerie Cullen et al. ANNALS OF NEUROLOGY
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models
- (2011) Y.H. Xu et al. MOLECULAR GENETICS AND METABOLISM
- Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
- (2011) Lydia Alvarez-Erviti et al. NEUROBIOLOGY OF DISEASE
- Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma
- (2011) Evangelia Emmanouilidou et al. PLoS One
- CNS expression of glucocerebrosidase corrects -synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
- (2011) S. P. Sardi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intracerebroventricular delivery of glucocerebrosidase reduces substrates and increases lifespan in a mouse model of neuronopathic Gaucher disease
- (2010) M.A. Cabrera-Salazar et al. EXPERIMENTAL NEUROLOGY
- Cell-Produced -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
- (2010) E. Emmanouilidou et al. JOURNAL OF NEUROSCIENCE
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins
- (2008) Ulrich Putz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started