S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NFκB signalling

HMGB1 as a Key Mediator of Immune Mechanisms in Ischemic Stroke

(2016) Vikramjeet Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Fingolimod induces neuroprotective factors in human astrocytes

(2015) Franziska S. Hoffmann et al.   Journal of Neuroinflammation

DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury

(2015) A. Liesz et al.   JOURNAL OF NEUROSCIENCE

Effect of FTY720-phosphate on the expression of inflammation-associated molecules in astrocytes in vitro

(2015) STEFANIE JANSSEN et al.   Molecular Medicine Reports

Blockade of high mobility group box-1 signaling via the receptor for advanced glycation end-products ameliorates inflammatory damage after acute intracerebral hemorrhage

(2015) Dan Li et al.   NEUROSCIENCE LETTERS

Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage

(2015) Kenji Yagi et al.   STROKE

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

(2015) Claudia Nussbaum et al.   Nature Communications

Rational modulation of the innate immune system for neuroprotection in ischemic stroke

(2015) Diana Amantea et al.   Frontiers in Neuroscience

Dynamic reactive astrocytes after focal ischemia

(2015) Shinghua Ding   Neural Regeneration Research

Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide

(2014) Emanuela Colombo et al.   ANNALS OF NEUROLOGY

Knock Out of S1P3 Receptor Signaling Attenuates Inflammation and Fibrosis in Bleomycin-Induced Lung Injury Mice Model

(2014) Ken Murakami et al.   PLoS One

Impact of an immune modulator fingolimod on acute ischemic stroke

(2014) Ying Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-ischemic inflammation regulates neural damage and protection

(2014) Takashi Shichita et al.   Frontiers in Cellular Neuroscience

Cellular signalling of the receptor for advanced glycation end products (RAGE)

(2013) Jianling Xie et al.   CELLULAR SIGNALLING

Nicorandil Inhibits Inflammasome Activation and Toll-Like Receptor-4 Signal Transduction to Protect against Oxygen-Glucose Deprivation-Induced Inflammation in BV-2 Cells

(2013) An-Peng Zhao et al.   CNS Neuroscience & Therapeutics

Circulating Monocytes Are Reduced by Sphingosine-1-Phosphate Receptor Modulators Independently of S1P3

(2013) N. D. Lewis et al.   JOURNAL OF IMMUNOLOGY

RAGE regulation and signaling in inflammation and beyond

(2013) Katrin Kierdorf et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis

(2013) Anthony O. Awojoodu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FTY720 Ameliorates Acute Ischemic Stroke in Mice by Reducing Thrombo-Inflammation but Not by Direct Neuroprotection

(2013) Peter Kraft et al.   STROKE

Relationship between plasma high-mobility group box-1 levels and clinical outcomes of ischemic stroke

(2012) Ju-Ming Huang et al.   JOURNAL OF CRITICAL CARE

Evaluating the role of Toll-like receptors in diseases of the central nervous system

(2011) Michael Carty et al.   BIOCHEMICAL PHARMACOLOGY

High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products

(2011) Andréy Mazarati et al.   EXPERIMENTAL NEUROLOGY

TLR2 and TLR4 expression after kidney ischemia and reperfusion injury in mice treated with FTY720

(2011) J.F. Pedregosa et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Toll-like receptors 2 and 4 in ischemic stroke: Outcome and therapeutic values

(2011) David Brea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Impact of Fingolimod (FTY720) in Neuroimmunologic Diseases

(2010) Aiden Haghikia et al.   AMERICAN JOURNAL OF PATHOLOGY

Fingolimod provides long-term protection in rodent models of cerebral ischemia

(2010) Ying Wei et al.   ANNALS OF NEUROLOGY

Reversal of Rotenone-Induced Dysfunction of Astrocytic Connexin43 by Opening Mitochondrial ATP-Sensitive Potassium Channels

(2010) Shu Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

(2010) K. Hyakkoku et al.   NEUROSCIENCE

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia

(2009) Bozena Czech et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ischemia activates JNK/c-Jun/AP-1 pathway to up-regulate 14-3-3γ in astrocyte

(2009) Yan Dong et al.   JOURNAL OF NEUROCHEMISTRY

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats

(2009) Yu Hasegawa et al.   STROKE

Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate

(2008) A. I. Duenas et al.   CARDIOVASCULAR RESEARCH

TLR4 and S1P receptors cooperate to enhance inflammatory cytokine production in human gingival epithelial cells

(2008) Mehmet A. Eskan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mechanisms of ischemic brain damage

(2008) Kristian P. Doyle et al.   NEUROPHARMACOLOGY

RAGE expression is up-regulated in human cerebral ischemia and pMCAO rats

(2008) Dong-Xu Zhai et al.   NEUROSCIENCE LETTERS