Mind the gap-deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites-a position paper focusing on carotenoids and polyphenols

Effects of cooking on in vitro sinigrin bioaccessibility, total phenols, antioxidant and antimutagenic activity of cauliflower (Brassica oleraceae L. var. Botrytis)

(2015) Nilüfer Girgin et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

Bioavailability of plant sterol-enriched milk-based fruit beverages: In vivo and in vitro studies

(2015) Guadalupe Garcia-Llatas et al.   Journal of Functional Foods

Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update

(2014) Ana Rodriguez-Mateos et al.   ARCHIVES OF TOXICOLOGY

In VitroModels for Studying Secondary Plant Metabolite Digestion and Bioaccessibility

(2014) M. Alminger et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Bioaccessibility, in vitro antioxidant activities and in vivo anti-inflammatory activities of a purple tomato (Solanum lycopersicum L.)

(2014) Hongyan Li et al.   FOOD CHEMISTRY

Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention

(2014) Claudia Vetrani et al.   FOOD RESEARCH INTERNATIONAL

Engineering liver

(2014) Linda G. Griffith et al.   HEPATOLOGY

Avoiding the Bad and Enhancing the Good of Soy Supplements in Breast Cancer

(2014) V. C. Jordan   JNCI-Journal of the National Cancer Institute

Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers

(2014) Rui C. Pimpão et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus-systematic review and meta-analysis

(2014) Heather A. Hausenblas et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Carotenoids, inflammation, and oxidative stress—implications of cellular signaling pathways and relation to chronic disease prevention

(2014) Anouk Kaulmann et al.   NUTRITION RESEARCH

Dietary factors affecting polyphenol bioavailability

(2014) Torsten Bohn   NUTRITION REVIEWS

Bioefficacy of tea catechins encapsulated in casein micelles tested on a normal mouse cell line (4D/WT) and its cancerous counterpart (D/v-src) before and after in vitro digestion

(2014) Sanaz Haratifar et al.   Food & Function

A standardised static in vitro digestion method suitable for food – an international consensus

(2014) M. Minekus et al.   Food & Function

Absorption, metabolism, and excretion of (–)-epicatechin in humans: an evaluation of recent findings

(2013) Alan Crozier   AMERICAN JOURNAL OF CLINICAL NUTRITION

Intestinal absorption, metabolism, and excretion of (–)-epicatechin in healthy humans assessed by using an intestinal perfusion technique

(2013) Lucas Actis-Goretta et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols

(2013) Michael N Clifford et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study

(2013) Charles Czank et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Complex interactions between dietary and genetic factors impact lycopene metabolism and distribution

(2013) Nancy E. Moran et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Absorption, metabolism, and excretion of fermented orange juice (poly)phenols in rats

(2013) Blanca Escudero-López et al.   BIOFACTORS

Physiologically relevant organs on chips

(2013) Kyungsuk Yum et al.   Biotechnology Journal

Relationships between Serum and Colon Concentrations of Carotenoids and Fatty Acids in Randomized Dietary Intervention Trial

(2013) A. Sen et al.   Cancer Prevention Research

A Review on the Relationship Between Food Structure, Processing, and Bioavailability

(2013) Ilkay Sensoy   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Structural and biochemical factors affecting the digestion of protein-stabilized emulsions

(2013) Harjinder Singh et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

The effects of flavonoids on the ABC transporters: consequences for the pharmacokinetics of substrate drugs

(2013) Yan Li et al.   Expert Opinion on Drug Metabolism & Toxicology

Microstructure and bioaccessibility of different carotenoid species as affected by high pressure homogenisation: A case study on differently coloured tomatoes

(2013) Agnese Panozzo et al.   FOOD CHEMISTRY

The effect of domestic processing on the content and bioaccessibility of carotenoids from chili peppers (Capsicum species)

(2013) Alessandro Pugliese et al.   FOOD CHEMISTRY

Stabilisation of strawberry (Fragaria x ananassa Duch.) anthocyanins by different pectins

(2013) M. Buchweitz et al.   FOOD CHEMISTRY

Flavonoid metabolites transport across a human BBB model

(2013) Ana Faria et al.   FOOD CHEMISTRY

Total phenolics content and antioxidant capacities of microencapsulated blueberry anthocyanins during in vitro digestion

(2013) Floirendo P. Flores et al.   FOOD CHEMISTRY

Fate of folates during vegetable juice processing — Deglutamylation and interconversion

(2013) Chao Wang et al.   FOOD RESEARCH INTERNATIONAL

The matrix effect of blueberry, oat meal and milk on polyphenols, antioxidant activity and potential bioavailability

(2013) Fatma Cebeci et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Volunteer Stratification Is More Relevant than Technological Treatment in Orange Juice Flavanone Bioavailability

(2013) María Tomás-Navarro et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Changes in Vitamin C, Phenolic, and Carotenoid Profiles Throughout in Vitro Gastrointestinal Digestion of a Blended Fruit Juice

(2013) María Janeth Rodríguez-Roque et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lutein and β-carotene content of green leafy Brassica species grown under different conditions

(2013) Constance Reif et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Dietary fat increases quercetin bioavailability in overweight adults

(2013) Yi Guo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cocoa flavanol metabolites activate HNF-3β, Sp1, and NFY-mediated transcription of apolipoprotein AI in human cells

(2013) Carlota Oleaga et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Accumulation of anthocyanins in tomato skin extends shelf life

(2013) Laura Bassolino et al.   NEW PHYTOLOGIST

Non-extractable polyphenols, a major dietary antioxidant: occurrence, metabolic fate and health effects

(2013) Jara Pérez-Jiménez et al.   NUTRITION RESEARCH REVIEWS

Deglycosylation is a key step in biotransformation and lifespan effects of quercetin-3-O-glucoside in Caenorhabditis elegans

(2013) Montserrat Dueñas et al.   PHARMACOLOGICAL RESEARCH

Effect of Antioxidant Vitamin Supplementation on Cardiovascular Outcomes: A Meta-Analysis of Randomized Controlled Trials

(2013) Yizhou Ye et al.   PLoS One

Food synergy: the key to a healthy diet

(2013) David R. Jacobs et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Chemical and microbiological considerations of phytosterols and their relative efficacies in functional foods for the lowering of serum cholesterol levels in humans: A review

(2013) Alfred Wong   Journal of Functional Foods

Bioavailability of dietary (poly)phenols: a study with ileostomists to discriminate between absorption in small and large intestine

(2013) Gina Borges et al.   Food & Function

The impact of in vitro digestion on bioaccessibility of polyphenols from potatoes and sweet potatoes and their influence on iron absorption by human intestinal cells

(2013) Lisa Miranda et al.   Food & Function

Absorption of Vitamin A and Carotenoids by the Enterocyte: Focus on Transport Proteins

(2013) Emmanuelle Reboul   Nutrients

Intestinal drug transporters: An overview

(2012) Margarida Estudante et al.   ADVANCED DRUG DELIVERY REVIEWS

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Bioavailability of bioactive food compounds: a challenging journey to bioefficacy

(2012) Maarit J. Rein et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

(Bio)chemical Labelling Tools for Studying Absorption & Metabolism of Dietary Phenols - An Overview

(2012)   CURRENT ORGANIC CHEMISTRY

Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches

(2012) Anna-Marja Aura et al.   EUROPEAN JOURNAL OF NUTRITION

Neuroprotective effects of digested polyphenols from wild blackberry species

(2012) Lucélia Tavares et al.   EUROPEAN JOURNAL OF NUTRITION

Lycopene degradation, isomerization and in vitro bioaccessibility in high pressure homogenized tomato puree containing oil: Effect of additional thermal and high pressure processing

(2012) Griet Knockaert et al.   FOOD CHEMISTRY

Effects of processing on anthocyanins, carotenoids and vitamin C in summer fruits and vegetables

(2012) Sze Ying Leong et al.   FOOD CHEMISTRY

Influence of chromoplast morphology on carotenoid bioaccessibility of carrot, mango, papaya, and tomato

(2012) Ralf M. Schweiggert et al.   FOOD CHEMISTRY

Effect of ultrasound treatments of tomato pulp on microstructure and lycopene in vitro bioaccessibility

(2012) Monica Anese et al.   FOOD CHEMISTRY

Effects of processing on phytochemical profiles and biological activities for production of sorghum tea

(2012) Li Wu et al.   FOOD RESEARCH INTERNATIONAL

Milk enhances intestinal absorption of green tea catechins in in vitro digestion/Caco-2 cells model

(2012) Yanlan Xie et al.   FOOD RESEARCH INTERNATIONAL

Elucidation of (−)-epicatechin metabolites after ingestion of chocolate by healthy humans

(2012) Lucas Actis-Goretta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bioaccessibility of Tocopherols, Carotenoids, and Ascorbic Acid from Milk- and Soy-Based Fruit Beverages: Influence of Food Matrix and Processing

(2012) Antonio Cilla et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-Inflammatory Procyanidins and Triterpenes in 109 Apple Varieties

(2012) Christelle M. Andre et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Review of the effects of food processing and formulation on flavonol and anthocyanin behaviour

(2012) Irina Ioannou et al.   JOURNAL OF FOOD ENGINEERING

Xanthones in Mangosteen Juice Are Absorbed and Partially Conjugated by Healthy Adults

(2012) Chureeporn Chitchumroonchokchai et al.   JOURNAL OF NUTRITION

Effect of boiling, roasting and frying on disintegration of peanuts in simulated gastric environment

(2012) Fanbin Kong et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Effects of physicochemical properties of carotenoids on their bioaccessibility, intestinal cell uptake, and blood and tissue concentrations

(2012) Charlotte Sy et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Human O-sulfated metabolites of (−)-epicatechin and methyl-(−)-epicatechin are poor substrates for commercial aryl-sulfatases: Implications for studies concerned with quantifying epicatechin bioavailability

(2012) S. Saha et al.   PHARMACOLOGICAL RESEARCH

In Vitro Microbiotic Fermentation Causes an Extensive Metabolite Turnover of Rye Bran Phytochemicals

(2012) Kati Hanhineva et al.   PLoS One

Persistence of Anticancer Activity in Berry Extracts after Simulated Gastrointestinal Digestion and Colonic Fermentation

(2012) Emma M. Brown et al.   PLoS One

Relevance and challenges in modeling human gastric and small intestinal digestion

(2012) Aurélie Guerra et al.   TRENDS IN BIOTECHNOLOGY

Comparison of phenolic acids and flavonoids in black garlic at different thermal processing steps

(2012) Ji-Sang Kim et al.   Journal of Functional Foods

Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study

(2011) Mari Maeda-Yamamoto et al.   CYTOTECHNOLOGY

Effect of refining processes on antioxidant capacity, total contents of phenolics and carotenoids in palm oils

(2011) Aleksandra Szydłowska-Czerniak et al.   FOOD CHEMISTRY

Influence of the chemical structure on the thermal degradation of the glucosinolates in broccoli sprouts

(2011) Franziska S. Hanschen et al.   FOOD CHEMISTRY

Neuroprotective effect of blackberry (Rubus sp.) polyphenols is potentiated after simulated gastrointestinal digestion

(2011) Lucélia Tavares et al.   FOOD CHEMISTRY

The impact of thermal processing on bioactive compounds in Australian native food products (bush tomato and Kakadu plum)

(2011) Sarana Sommano et al.   FOOD RESEARCH INTERNATIONAL

Distribution of thiolated mucoadhesive nanoparticles on intestinal mucosa

(2011) Sarah Dünnhaupt et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bioavailability of β-Cryptoxanthin in the Presence of Phytosterols: In Vitro and in Vivo Studies

(2011) Fernando Granado-Lorencio et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Combined Pressure–Temperature Effects on Carotenoid Retention and Bioaccessibility in Tomato Juice

(2011) Rockendra Gupta et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Role of Dietary Fiber in the Bioaccessibility and Bioavailability of Fruit and Vegetable Antioxidants

(2011) Hugo Palafox-Carlos et al.   JOURNAL OF FOOD SCIENCE

High Pressure Homogenization Increases the In Vitro Bioaccessibility of α- and β-Carotene in Carrot Emulsions But Not of Lycopene in Tomato Emulsions

(2011) Cecilia A. Svelander et al.   JOURNAL OF FOOD SCIENCE

Divalent Minerals Decrease Micellarization and Uptake of Carotenoids and Digestion Products into Caco-2 Cells

(2011) Eric Biehler et al.   JOURNAL OF NUTRITION

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

(2011) Dulantha Ulluwishewa et al.   JOURNAL OF NUTRITION

Genetic variations involved in interindividual variability in carotenoid status

(2011) Patrick Borel   MOLECULAR NUTRITION & FOOD RESEARCH

Bioavailability of Phytochemical Constituents From a Novel Soy Fortified Lycopene Rich Tomato Juice Developed for Targeted Cancer Prevention Trials

(2011) Torsten Bohn et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes

(2011) Emmanuelle Reboul et al.   PROGRESS IN LIPID RESEARCH

Effects of O-methylated metabolites of quercetin on oxidative stress, thermotolerance, lifespan and bioavailability on Caenorhabditis elegans

(2011) Felipe Surco-Laos et al.   Food & Function

Effect of processing methods on the nutraceutical and antioxidant properties of little millet (Panicum sumatrense) extracts

(2010) S.R. Pradeep et al.   FOOD CHEMISTRY

High pressure homogenization followed by thermal processing of tomato pulp: Influence on microstructure and lycopene in vitro bioaccessibility

(2010) Ines Colle et al.   FOOD RESEARCH INTERNATIONAL

Cooking methods of Brassica rapa affect the preservation of glucosinolates, phenolics and vitamin C

(2010) Marta Francisco et al.   FOOD RESEARCH INTERNATIONAL

Chocolate Matrix Factors Modulate the Pharmacokinetic Behavior of Cocoa Flavan-3-ol Phase II Metabolites Following Oral Consumption by Sprague−Dawley Rats

(2010) Andrew P. Neilson et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of Carrot (Daucus carota) Microstructure on Carotene Bioaccessibility in the Upper Gastrointestinal Tract. 2. In Vivo Digestions

(2010) Elizabeth A. Tydeman et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Flavonoids and age-related disease: Risk, benefits and critical windows

(2010) J.K. Prasain et al.   MATURITAS

Nonextractable polyphenols, usually ignored, are the major part of dietary polyphenols: A study on the Spanish diet

(2010) Sara Arranz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Multiple facets of intestinal permeability and epithelial handling of dietary antigens

(2010) S Ménard et al.   Mucosal Immunology

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

(2010) Laura Bravo   NUTRITION REVIEWS

The influence of beverage composition on delivery of phenolic compounds from coffee and tea

(2010) Mario G. Ferruzzi   PHYSIOLOGY & BEHAVIOR

In vitro approaches to estimate the effect of food processing on carotenoid bioavailability need thorough understanding of process induced microstructural changes

(2010) Sandy Van Buggenhout et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites

(2010) Maria Monagas et al.   Food & Function

Mechanistic Approaches to Predicting Oral Drug Absorption

(2009) Weili Huang et al.   AAPS Journal

Micro- and macrorheology of mucus

(2009) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

Interindividual differences in response to plant-based diets: implications for cancer risk

(2009) Johanna W Lampe   AMERICAN JOURNAL OF CLINICAL NUTRITION

Current developments on the inhibitory effects of berry polyphenols on digestive enzymes

(2009) Gordon J. McDougall et al.   BIOFACTORS

Pectins in Processed Fruits and Vegetables: Part III-Texture Engineering

(2009) S. Van Buggenhout et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Nutritional Approaches and Health-Related Properties of Plant Foods Processed by High Pressure and Pulsed Electric Fields

(2009) Concepción Sánchez-Moreno et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Curcumin as an Anti-Cancer Agent: Review of the Gap Between Basic and Clinical Applications

(2009) G. Bar-Sela et al.   CURRENT MEDICINAL CHEMISTRY

Modes of Disintegration of Solid Foods in Simulated Gastric Environment

(2009) Fanbin Kong et al.   Food Biophysics

Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea

(2009) Catrina M. Peters et al.   FOOD RESEARCH INTERNATIONAL

Improving the oral bioavailability of beneficial polyphenols through designed synergies

(2009) Arjan Scheepens et al.   Genes and Nutrition

Effect of Fat Content on the Digestibility and Bioaccessibility of Cocoa Polyphenol by an in Vitro Digestion Model

(2009) Nàdia Ortega et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Influence of Chocolate Matrix Composition on Cocoa Flavan-3-ol Bioaccessibility In Vitro and Bioavailability in Humans

(2009) Andrew P. Neilson et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Procyanidin Dimers A1, A2, and B2 Are Absorbed without Conjugation or Methylation from the Small Intestine of Rats

(2009) Maaike M. Appeldoorn et al.   JOURNAL OF NUTRITION

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Controlling Lipid Bioavailability through Physicochemical and Structural Approaches

(2008) David Julian McClements et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants

(2008) Birgit Holst et al.   CURRENT OPINION IN BIOTECHNOLOGY

Factors affecting the conversion of apple polyphenols to phenolic acids and fruit matrix to short-chain fatty acids by human faecal microbiota in vitro

(2008) Sarah Bazzocco et al.   EUROPEAN JOURNAL OF NUTRITION

Effect of thermal treatment on glucosinolates and antioxidant-related parameters in red cabbage (Brassica oleracea L. ssp. capitata f. rubra)

(2008) Jon Volden et al.   FOOD CHEMISTRY

Total phenolic compounds and antioxidant capacity of wheat graded flours by polishing method

(2008) Pham Van Hung et al.   FOOD RESEARCH INTERNATIONAL

GC–MS methods for metabolic profiling of microbial fermentation products of dietary polyphenols in human and in vitro intervention studies

(2008) Christian H. Grün et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A Model Stomach System to Investigate Disintegration Kinetics of Solid Foods during Gastric Digestion

(2008) F. Kong et al.   JOURNAL OF FOOD SCIENCE

Glucosinolates in Brassica vegetables: The influence of the food supply chain on intake, bioavailability and human health

(2008) Ruud Verkerk et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

(2008) Neil Parrott et al.   MOLECULAR PHARMACEUTICS

Intestinal Breast Cancer Resistance Protein (BCRP)/Bcrp1 and Multidrug Resistance Protein 3 (MRP3)/Mrp3 Are Involved in the Pharmacokinetics of Resveratrol

(2008) K. van de Wetering et al.   MOLECULAR PHARMACOLOGY

Microbial metabolism of catechin stereoisomers by human faecal microbiota: Comparison of targeted analysis and a non-targeted metabolomics method

(2008) Anna-Marja Aura et al.   Phytochemistry Letters

1H NMR metabolite profiling of feces as a tool to assess the impact of nutrition on the human microbiome

(2007) Doris M. Jacobs et al.   NMR IN BIOMEDICINE